A four-dimensional organoid system to visualize cancer cell vascular invasion (Biology, 2020, in press)

A four-dimensional organoid system to visualize cancer cell vascular invasion (Biology, 2020, in press)
In collaboration with Osaka University Graduate School of Medicine, Department of Gastroenterology (Profs Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori) and Graduate School of Engineering, Department of Applied Chemistry (Prof Michiya Matsusaki), Yanagisawa et al. studied a four-dimensional (4D) organoid system to visualize cancer cell vascular invasion. Using this model, it was possible to observe and evaluate the cell dynamics and histological positional relationship of invasive cancer cells in four dimensions. Thus, drug discovery using this vascular invasion mimic model will be advanced and many applications are expected. 

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