RESULTS

Direct observation of DNA alterations induced by DNA disruptor (Scientific Reports, 2022)

Detection of DNA alterations caused by exposure to exogenous reagents is important for the precision medicine.  We performed a single-molecule electrical detection method for the direct observation of DNA alterations. We found that the trifluridine (FTD) incorporation at the p53 DNA binding regions led to its less binding. This work suggests that single-molecule detection of DNA sequence alterations is a useful methodology for understanding DNA sequence alterations.