RESULTS

Targeting the regulation of aberrant protein production pathway in gastrointestinal cancer treatment (Front Oncol, 2022)

In the collaboration with Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Japan (Professors Eguchi and Doki), Dr. Sato has focused on the novel mechanism of endogenous functional RNAs acting as damage-associated molecular patterns for the process of the regulation of the aberrant protein production (RAPP). Given that unshielded 7SL1 in exosomes possesses an immune stimulatory property, it has been applied to the chimeric antigen receptor therapy against intractable solid cancer. Recent progress in RAPP knowledge in gastrointestinal cancer therapy are noteworthy.