RESULTS

Hedgehog-Wnt crosstalk in tumor-promoting cell competition (Dev Cell, 2026)

The international collaboration demonstrated that intratumoral heterogeneity promotes cancer progression through interclonal communication. This study identifies a conserved Hh–Wnt signaling mechanism, enhancing invasion and tumor growth. The findings reveal Hh–Wnt crosstalk as a potential therapeutic vulnerability in heterogeneous cancers.