RESULTS

Cell-free culture conditioned medium elicits pancreatic β-cell lineage-specific epigenetic reprogramming (Oncology Reports, 2016)

In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Kawamoto and Ohashi et al. demonstrate that cell-free culture conditioned medium elicits pancreatic β-cell lineage-specific epigenetic reprogramming in mice. The study showed that the transfer of epigenetic phenotypes was achieved in the cell-free system of pancreatic insulinoma cell culture. These findings provide further support for the utility of cell-free conditioned medium for cellular reprogramming and the regenerative medicine.