|
|
平成24〜25年度： 公募研究03
独自の正常大腸上皮幹細胞培養技術を用いた管腔形成機構の解析
英文原著論文
- Suzuki, M., Nagaishi, T., Yamazaki, M., Onizawa, T., Watabe, T., Sakamaki, Y., Ichinose, S., Totsuka, M., Oshima, S., Okamoto, R., Shimonaka, M., Yagita, H., Nakamura, T., Watanabe, M. Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS One, (in press).
- Murano, T., Okamoto, R., Ito, G., Nakata, T., Hibiya, S., Shimizu, H., Fujii, S., Kano, Y., Mizutani, T., Yui, S., Akiyama-Morio, J., Nemoto, Y., Tsuchiya, K., Nakamura, T., Watanabe, M. Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem. Biophys. Res. Commun. 443(3): 840-846, 2013.
- Fordham, RP., Yui, S., Hannan, NRF., Søndergaard, C., Madgwick, A., Schweiger, PJ., Nielsen, OH., Vallier, L., Pedersen, RA., Nakamura, T., Watanabe, M., Jensen, KB. Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell 13(6): 734-744, 2013.
- Ito, G., Okamoto, R., Murano, T., Shimizu, H., Fujii, S., Nakata, T., Mizutani, T., Yui, S., Akiyama-Morio, J., Nemoto, Y., Okada, E., Araki, A., Ohtsuka, K., Tsuchiya, K., Nakamura, T., Watanabe, M. Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells. PLoS One 8(11): e79693, 2013.
- Kano, Y., Tsuchiya, K., Zheng, X., Horita, N., Fukushima, K., Hibiya, S., Yamauchi, Y., Nishimura, T., Hinohara, K., Gotoh, N., Suzuki, S., Okamoto, R., Nakamura, T., Watanabe, M. The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem. Biophys. Res. Commun. 432(1): 175-181, 2013.
- Nemoto, Y., Kanai, T., Takahara, M., Oshima, S., Nakamura, T., Okamoto, R., Tsuchiya, K., Watanabe, M. Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells. Gut 62(8): 1142-1152, 2013.
- Yui, S*., Nakamura, T*., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H., Watanabe, M. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nat. Med. 18(4): 618-623, 2012.
- Yamaji, O., Nagaishi, T., Totsuka, T., Onizawa, M., Suzuki, M., Tsuge, N., Hasegawa, A., Okamoto, R., Tsuchiya, K., Nakamura, T., Arase, H., Kanai, T., Watanabe, M. The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis. J. Immunol. 188(6): 2524-2536, 2012.
- Mizutani, T*., Nakamura, T*., §., Morikawa, R., Fukuda, M., Mochizuki, W., Yamauchi, Y., Nozaki, K., Yui, S., Nemoto, Y., Nagaishi, T., Okamoto, R., Tsuchiya, K., Watanabe, M. Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem. Biophys. Res. Commun. 419(2): 238-243, 2012.
和文総説
- 中村哲也： 腸管幹細胞からの大腸粘膜の再生．内分泌・糖尿病・代謝内科: 36巻3号、249-254, 2013.
- 中村哲也、渡辺 守： 医学と医療の最前線「腸上皮幹細胞による腸管再生と粘膜治癒をめざして」日本内科学会雑誌：101巻12号、3533-3539, 2012.
- 中村哲也、渡辺 守： 培養幹細胞を用いる大腸再生治療の可能性:医学のあゆみ: 243巻2号、185、2012.
- 中村哲也、油井史郎、渡辺 守： 上皮細胞移植は消化管を再生できるか：分子消化器病: 9巻2号、113-118、2012.
- 中村哲也、油井史郎、水谷知裕、渡辺 守： 腸上皮の幹細胞：G.I.Research: 20巻1号、16-20、2012.
|
平成24〜25年度： 公募研究02へ
