業績

1) Uno H, Itokazu T*, Yamashita T*. Inhibition of repulsive guidance molecule A ameliorates diabetes-induced cognitive decline and hippocampal neurogenesis impairment in mice.
Communications Biology. 2025 in press.

2) Yamamoto M, Itokazu T*, Uno H, Maki T, Shibuya N, Yamashita T*. Anti-RGMa neutralizing antibody ameliorates vascular cognitive impairment in mice.
Neurotherapeutics. in press. doi: 10.1016/j.neurot.2024.e00500.

3) Nakagawa R, Itokazu T*, Shibuya N, Kishima H,Yamashita T*. Perivascular Neutrophil  Extracellular Traps Exacerbate Microvasospasm After Experimental Subarachnoid Hemorrhage.
 Stroke. 2024，doi: 10.1161/STROKEAHA.124.047574.

4) Ohtake M#, Abe K#, Hasegawa M#, Itokazu T # (# equal contribution), Selvakumar V, Matunis A, Stacy E, Froeblich E, Huynh N, Lee H, Kambe Y, Yamamoto T, Sato TK, Sato TR. Encoding of self-initiated actions in axon terminals of the mesocortical pathway.
 Neurophotonics, 2024, 11(3):033408

5) Abe K, Kambe Y, Majima K, Hu Z, Ohtake M, Momennezhad A, Izumi H, Tanaka T, Matunis
 A, Stacy E, Itokazu T, Sato TR, Sato T. Functional diversity of dopamine axons in prefrontal cortex during classical conditioning.
 Elife, 2024, 12:RP91136

6) Hong B, Ohtake Y, Itokazu T*, Yamashita T*.      Glial senescence enhances α-synuclein  pathology owing to its insufficient clearance caused by autophagy dysfunction.
 Cell Death Discovery, 2024, 10(1):50

7) Furumiya T, Itokazu T*, Nakanishi T, Yamashita T*. CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice.
 Neuroscience Resarch, 2023, 191:38-47

8) Shibuya N, Itokazu T*, Ueda T, Yamashita T*. Intravital Imaging Reveals the Ameliorating Effect of Colchicine in a Photothrombotic Stroke Model via Inhibition of Neutrophil Recruitment.
 Translational Stroke Research, 2023, 14(1):100-110

9) Morita Y, Itokazu T*, Nakanishi T, Hiraga SI, Yamashita T*.              A novel aquaporin-4- associated optic neuritis rat model with severe pathological and functional manifestations.
 Journal of Neuroinflammation, 2022, 19(1):263

10) Hirata T, Itokazu T*, Sasaki A,  Sugihara F, Yamashita T*.              Humanized Anti-RGMa  Antibody Treatment Promotes Repair of Blood-Spinal Cord Barrier Under Autoimmune  Encephalomyelitis in Mice.
 Frontiers in Immunology, 2022, 13:870126

11) Fatoba O, Itokazu T, Yamashita T. Complement cascade functions during brain development and neurodegeneration.
 FEBS Journal, 2022, 289(8):2085-2109

12) Iwamoto S, Itokazu T*, Sasaki A, Kataoka H, Tanaka S, Hirata T, Miwa K, Suenaga T, Takai Y, Misu T, Fujihara K, Yamashita T*. RGMa Signal in Macrophages Induces Neutrophil-Related Astrocytopathy in NMO.
 Annals of Neurology, 2022, 91(4):532-547.

13) Hiraga SI, Itokazu T*, Nishibe M, Yamashita T*. Neuroplasticity related to chronic pain and its modulation by microglia.
 Inflammation and Regeneration, 2022, 42(1):15

14) Miyajima H, Itokazu T*, Tanabe S, Yamashita T*. Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice.
 Cell Death and Disease, 2021, 12(8):766

15) Parajuli G, Tekguc M, Wing JB, Hashimoto A, Okuzaki D, Hirata T, Sasaki A, Itokazu T,
 Handa H, Sugino H, Nishikawa Y, Metwally H, Kodama Y, Tanaka S, Sabe H, Yamashita T,
 Sakaguchi S, Kishimoto T, Hashimoto S.   Arid5a Promotes Immune Evasion by Augmenting
 Tryptophan Metabolism and Chemokine Expression.          
 Cancer Immunology Research, 2021, 9(8):862-876

16) Hiraga SI, Itokazu T*, Hoshiko M, Takaya H, Nishibe M, Yamashita T*. Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting.          
 JCI Insight, 2020, 42(1):15

17) Fatoba O, Itokazu T, Yamashita T. Microglia as therapeutic target in central nervous system disorders.
 Journal of Pharmacological Sciences, 2020, 144(3):102-118

18) Fatoba O, Ohtake Y, Itokazu T, Yamashita T. Immunotherapies in Huntington's disease and α-Synucleinopathies.
 Frontiers in Immunology, 2020, 11:337

19) Sato TR#, Itokazu T# (# equal contribution), Osaki H#, Ohtake M, Yamamoto T, Sohya K, Maki T, Sato TK. Interhemispherically dynamic representation of an eye movement-related activity in mouse frontal cortex.  
 Elife, 2019, 8:e50855

20) Tanabe S, Saitoh S, Miyajima H, Itokazu T, Yamashita T. Microglia suppress the secondary progression of autoimmune encephalomyelitis.              
 Glia, 2019, 67(9):1694-1704

21) Itokazu T, Hasegawa M, Kimura R, Osaki H, Albrecht UR, Sohya K, Chakrabarti S, Itoh H, Ito T, Sato TK, Sato TR. Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task.
 Nature Communications, 2018, 9(1):338

22) Hasegawa M, Majima K, Itokazu T, Maki T, Albrecht UR, Castner N, Izumo M, Sohya K, Sato TK, Kamitani Y, Sato TR.            Selective Suppression of Local Circuits during Movement Preparation in the Mouse Motor Cortex.       
 Cell Reports, 2017, 18(11):2676-2686

23) Niethard N, Hasegawa M, Itokazu T, Oyanedel CN, Born J, Sato TR. Sleep-Stage-Specific
 Regulation of Cortical Excitation and Inhibition.  
 Current Biology, 2016, 26(20):2739-2749

24) Itokazu T, Hayano Y, Takahashi R, Yamashita T. Involvement of Wnt/β-catenin signaling in the development of neuropathic pain.
 Neuroscience Resarch, 2014, 79:34-40

25) Nakagawa H, Ueno M, Itokazu T, Yamashita T. Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice.              
 Cell Death and Disease, 2013, 4(3):e534

26) Jin X, Ishii H, Bai Z, Itokazu T, Yamashita T.     Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice.
 PLoS One, 2012, 7(7):e41892

27) Itokazu T, Hayano Y, Takahashi R, Yamashita T. Identification of the neogenin-binding site on the repulsive guidance molecule A.
 PLoS One, 2012, 7(3):e32791