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2024年 [ 2024年|2023年2022年2021年2020年2019年2018年2017年(2016年以前→)
  • Hong, B., Ohtake, Y., Itokazu, T. and Yamashita, T. (2024) Glial senescence enhances α-synuclein pathology owing to its insufficient clearance caused by autophagy dysfunction. Cell Death Discovery
  • Fukuda, M., Fujita, Y., Hino, Y., Nakano, M., Shirahige, K. and Yamashita, T. (2024) Inhibition of HDAC8 reduces the proliferation of adult neural stem cells in the subventricular zone. Int. J. Mol. Sci.
  • Katsu, M., Sekine-Tanaka, M., Tanaka, M., Horai, M., Akarsuka, A., Suga, M., Kiyohara, K., Fujita, T., Sasaki, A. and Yamashita, T. (2024) Inhibition of repulsive guidance molecule-a ameliorates compromised blood–spinal cord barrier integrity associated with neuromyelitis optica in rats. J. Neuroimmunol.
  • Hamano, S., Yoshimizu, T., Mori, M., Iida, A. and Yamashita, T. (2024) Characterization of pathological stages in a mouse model of progressive multiple sclerosis. Neurosci. Res.
2023年 2024年| 2023年|2022年2021年2020年2019年2018年2017年(2016年以前→)
  • Shimizu, M., Shiraishi, N., Tada, S., Sasaki, T., Beck G., Nagano, S., Kinoshita, M., Sumi, H., Sugimoto, T., Ishida, Y., Koda, T., Ishikura, T., Sugiyama, Y., Kihara, K., Kanakura, Y., Nakajima, T., Takeda, S, Takahashi, M.,Yamashita, T., Okuno, T., Mochizuki, H. (2023) RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS. Sci. Adv. 9, eadg3193.
  • Tsujioka, H. and Yamashita, T. (2023) Utilization of ethanolamine phosphate phospholyase as a unique astrocytic marker. Front. Cell. Neurosci. 17:1097512.
  • Shibuya, N., Itokazu, T., Ueda, T. and Yamashita, T. (2023) Intravital imaging reveals the ameliorating effect of colchicine in a photothrombotic stroke model via inhibition of neutrophil recruitment. Trans. Stroke Res. 14, 100-110.
  • Kuroda, Y., Iwata-Otsubo, A., Dias, K.R., Temple, S.E.L., Nagao, K., Hayr, L.D., Zhu, Y., Isobe, S.Y., Nishibuchi, G., Fiordaliso, S.K., Fujita, Y., Ritter, A.L., Baker, S.W., Leung, M.L., Koboldt, D.C., Harman, A., Keena, B.A., Izumi, K., Subramanian, G.M., Manickam, K., Schmalz, B., Latsko, M., Zackai, E.H., Edwards, M., Evans, C.A., Dulik, M.C., Buckley, M.F., Yamashita, T., Timothy, W., Robert, O., Harvey, J., Obuse, C., Roscioli, T., Izumi, K. (2023) Dominant-negative variants in CBX1 cause a neurodevelopmental disorder. Genet. Med. 25, 100861.
  • Furumiya, T., Itokazu, T., Nakanishi, T. and Yamashita, T. (2023) CXCR4 signaling regulates repair Schwann cell infiltration into the spinal cord after spinal cord injury in mice. Neurosci. Res.191, 38-47.
  • Matsudaira, T., Nakano, S., Konishi, Y., Kawamoto, S., Uemura, K., Kondo, T., Sakurai, K., Ozawa, T., Hikida, T., Komine, O., Yamanaka, K., Fujita, Y., Yamashita, T., Matsumoto, T. and Hara, E. (2023) Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype. Comm. Biol. 6, 665.
  • Sawada, M., Yoshino-Saito, K., Ninomiya, T., Oishi, T., Yamashita, T., Hirotake, O., Takada, M., Nishimura, Y. and Isa, T. (2023) Reorganization of corticospinal projections after prominent recovery of finger dexterity from partial spinal cord injury in macaque monkeys. eNeuro
  • Abbaoui, A., Fatoba, O. and Yamashita, T. (2023) Meningeal T cells function in the central nervous system homeostasis and neurodegenerative diseases. Front. Cell. Neurosci. 17, 1181071.
  • Mohamed, W., Kumar, J., Alghamdi, B.S., Soliman, A.H. and Yamashita, T. (2023) Neurodegeneration and inflammation crosstalk: Therapeutic targets and perspectives. IBRO Rep. 14, 95-110.
  • 山下俊英: 神経疾患治療のためのヒト化抗RGMa抗体の開発、化学工業、74: 7-12, 2023
  • 山下俊英: 神経,免疫,血液脳関門を制御する治療薬の開発、神経治療学、40: 426-431, 2023
2022年 2024年2023年|2022年|2021年2020年2019年2018年2017年(2016年以前→)
  • Iwamoto, S., Itokazu, T., Sasaki, A., Kataoka, H., Tanaka, S., Hirata, T., Miwa, K., Suenaga, T., Takai, Y., Misu, T., Fujihara, K. and Yamashita, T. (2022) RGMa signal in macrophages induces neutrophil-related astrocytopathy in NMO. An. Neurol.91, 532-547.
  • Hasebe, R., Murakami, K., Harada, M., Halaka, N. Nakagawa, H., Kawano, F., Ohira, Y., Kawamoto, T., Yull, F.E., Blackwell, T.S., Nio-Kobayashi, J., Iwanaga, T., Watanabe, M., Watanabe, N., Hotta, H., Yamashita, T., Kamimura, D., Tanaka, Y. and Murakami, M. (2022) ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons. J. Exp. Med. 219, e20212019.
  • Morita, Y., Itokazu, T., Nakanishi, T., Hiraga, S. and Yamashita, T. (2022) A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations. J. Neuroinflamm. 19, 263.
  • Hirata, T., Itokazu, T., Sasaki, A., Sugihara, F. and Yamashita, T. (2022) Humanized anti-RGMa antibody treatment promotes repair of blood-spinal cord barrier under autoimmune encephalomyelitis in mice. Front. Immunol. 13, 870126.
  • Ikeda-Yorifuji, I., Tsujioka, H., Sakata, Y. and Yamashita, T. (2022) Single-nucleus RNA sequencing identified cells with ependymal cell-like features enriched in neonatal mice after spinal cord injury. Neurosci. Res.181,22-38.
  • Ahmed, K.M.A.A., Nakagawa, H., Isaksen, T.J., and Yamashita, T. (2022) The effects of Bone Morphogenetic Protein 4 on adult neural stem cell proliferation, differentiation and survival in an in vitro model of ischemic stroke. Neurosci. Res.183,17-29.
  • Nishibe, M., Toyoda, H., Hiraga, S., Yamashita, T., Katsuyama, Y. (2022) Synaptic and genetic bases of impaired motor learning associated with modified experience-dependent cortical plasticity in heterozygous reeler mutants.Cereb. Cortex .32, 504-519.
  • Hiraga, S, Itokazu, T., Nishibe, M. and Yamashita, T. (2022) Neuroplasticity related to chronic pain and its modulation by microglia. Inflammation and Regeneration 42, 15.
  • Ninomiya, T., Nakagawa, H., Inoue, K., Nishimura, Y., Oishi, T., Yamashita, T. and Takada, M. (2022) Origin of multisynaptic corticospinal pathway to forelimb segments in macaques and its reorganization after spinal cord injury. Front. Neural Circuit 16, 847100.
  • Fatoba, O., Itokazu, T. and Yamashita, T. (2022) Complement cascade functions during brain development and neurodegeneration. FEBS J. 289, 2085-2109.
  • Mohamed, W.M.Y., Yi, C., Soreq, L. and Yamashita, T. (2022) Editorial: Genes and aging: From bench-to-bedside. Front. Aging Neurosci. 14, 886967.
  • Mohamed, W. and Yamashita, T. (book editors) (2022) Role of micronutrients in brain health. Springer.
  • 山下俊英: 脊髄損傷治療薬としてのヒト化抗RGMa抗体の開発と治験、関節外科、41: 250-257, 2022
2021年 2024年2023年2022年|2021年|2020年2019年2018年2017年(2016年以前→)
  • Ito, M., Muramatsu, R., Kato, Y., Sharma, B., Uyeda, A., Tanabe, S., Fujimura, H., Kidoya, H., Takakura, N., Kawahara, Y., Takao, M., Mochizuki, H., Fukamizu, A. and Yamashita, T. (2021) Age-dependent decline in myelination capacity is mediated by apelin-APJ signaling. Nature Aging 1, 284-294.
  • Oda, W., Fujita, Y., Baba, K., Mochizuki, H., Niwa, H. and Yamashita, T. (2021) Inhibition of repulsive guidance molecule-a protects dopaminergic neurons in a mouse model of Parkinson’s disease. Cell Death Dis. 12, 181.
  • Miyajima, H., Itokazu, T., Tanabe, S. and Yamashita, T. (2021) Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice. Cell Death Dis. 12, 766.
  • Honjo, Y., Fujita, Y., Niwa, H. and Yamashita, T. (2021) Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury. PLOS ONE 16, e0251013.
  • Yamanaka, H., Tanaka, Y., Nakagawa, H., Yamanaka-Isosaka, T., Yamashita, T. and Takada, M. (2021) An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury. PLOS ONE 16, e0252023.
  • Parajuli, G., Tekguc, M., Wing, J.B., Hashimoto, A., Okuzaki, D., Hirata, T., Sasaki, A., Itokazu, T., Handa, H., Sugino, H., Nishikawa, Y., Metwally, H., Kodama, Y., Tanaka, S., Sabe, H., Yamashita, T., Sakaguchi, S., Kishimoto, T. and Hashimoto, S. (2021) Arid5a promotes immune evasion by augmenting tryptophan metabolism and chemokine expression. Cancer Immunol. Res. 9, 862-876.
  • Matoba, K., Yamashita, S., Isaksen, T.J. and Yamashita, T. (2021) Proton-sensing receptor GPR132 facilitates migration of astrocytes. Neurosci. Res.170,106-113.
  • Tsujioka, H. and Yamashita, T. (2021) Neural circuit repair after central nervous system injury. Int. Immunol.33,301-309.
  • Fujita, Y. and Yamashita, T. (2021) Mechanisms and significance of microglia-axon interactions in physiological and pathophysiological conditions. Cell. Mol. Life. Sci.78,3907-3919.
  • Fujita, Y. and Yamashita, T. (2021) Alterations in chromatin structure and function in the microglia. Front. Cell Dev. Biol. 8, 626541.
  • Fujita, Y. and Yamashita, T. (2021) Neuroprotective function of microglia in the developing brain. Neuronal Signal. 5, NS20200024.
  • Ahmed, A.K.M.A., Isaksen, T.J. and Yamashita, T. (2021) Preparation of mouse adult neural stem cells. Star Protocols 2, 100522.
  • 山下俊英: 中枢神経障害による神経症状を改善する治療薬の開発、神経治療学、37: 315-318, 2020 (2021年2月5日公表)
  • 山下俊英: 複合的治療開発が開く未来、特集総論「神経の修復と再生の最前線」、BIO Clinica、36, 4-5, 2021
  • 山下俊英: 中枢神経の修復・再生のための治療薬の開発、特集各論「神経の修復と再生の最前線」、BIO Clinica、36, 11-15, 2021
  • 山下俊英: 中枢神経障害による神経症状を改善する治療薬の開発、Annual Review神経2021、p89-94、2021
2020年 2024年2023年2022年2021年|2020年|2019年2018年2017年(2016年以前→)
  • Fujita, Y., Nakanishi, T., Ueno, M., Itohara, S. and Yamashita, T. (2020) Netrin-G1 regulates microglial accumulation along axons and supports the survival of layer V neurons in the postnatal mouse brain. Cell Rep. 31, 107580.
  • Isaksen, T.J., Fujita, Y. and Yamashita, T. (2020) Repulsive guidance molecule A suppresses adult neurogenesis. Stem Cell Rep. 14, 677-691.
  • Hiraga, S., Itokazu, T., Hoshiko, M., Takaya, H., Nishibe, M and Yamashita, T. (2020) Microglial depletion under thalamic hemorrhage ameliorates mechanical allodynia and suppresses aberrant axonal sprouting of the thalamo-cortical projection in mice. JCI Insight 5, e131801
  • Sada, N., Fujita, Y., Mizuta, N., Ueno, M., Furukawa, T. and Yamashita, T. (2020) Inhibition of HDAC increases BDNF expression and promotes neuronal rewiring and functional recovery after brain injury. Cell Death Dis. 11, 655.
  • Nakazato, Y., Fujita, Y., Nakazato, M. and Yamashita, T. (2020) Neurons promote encephalitogenic CD4+ lymphocyte infiltration in experimental autoimmune encephalomyelitis. Sci. Rep. 10, 7354.
  • Abe, Y., Honsho, M., Kawaguchi, R., Matsuzaki, T., Ichiki, Y., Fujitani, M., Fujiwara, K., Hirokane, M., Oku, M., Sakai, Y., Yamashita, T., Fujiki, Y. (2020) A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurrotrophic factor pathway. J. Biol. Chem. 295, 5321-5334.
  • Ozaki, T., Muramatsu, R., Nakamura, H., Kinoshita, M., Kishima, H. and Yamashita, T. (2020) Proteomic analysis of protein changes in plasma by balloon test occlusion. J. Clin. Neurosci. 72, 397-401.
  • Tanabe, S. and Yamashita, T. (2020) Function of lymphocytes in oligodendrocyte development. Neuroscientist 26, 74-86.
  • Fatoba, O., Ohtake, Y., Itokazu, T. and Yamashita, T. (2020) Immunotherapies in PolyQ disorders and α-Synucleinopathies. Front. Immunol. 11, 337.
  • Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, AJ., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W.K. and Kuroiwa, T. (2020) Recent insights into peroxisome biogenesis and associated diseass. J. Cell Sci. 133, jcs236943.
  • Fatoba, O, Itokazu, T. and Yamashita, T. (2020) Microglia as therapeutic target in central nervous system disorders. J. Pharmacol. Sci. 144, 102-118.
  • Isaksen, T.J. and Yamashita, T. (2020) Repulsive guidance molecule A regulates adult neurogenesis via the Neogenin receptor. Neurosci. Insights 15, 2633105520948481.
  • Abe, Y., Nishimura, Y., Nakamura, K., Tamura, S., Honsho, M., Udo, H., Yamashita, T. and Fujiki, Y. (2020) Peroxisome deficiency impairs BDNF signaling and memory. Front. Cell Dev. Biol. 8, 567017.
  • Fujita, Y. and Yamashita, T. (2020) Protocol for co-culture of microglia with axons. STAR Protocols 1, 100111.
  • 山下俊英: 中枢神経回路の修復を促進する抗体治療薬の開発、J. Clin. Rehabilitation、29: 272-276, 2020
2019年 2024年2023年2022年2021年2020年|2019年|2018年2017年(2016年以前→)
  • Hamaguchi, M., Muramatsu, R., Fujimura, H., Mochizuki, H., Kataoka, H. and Yamashita, T. (2019) Circulating transforming growth factor-b1 facilitates remyelination in the adult central nervous system. eLife 8, e41869.
  • Yamada, M., Fujita, Y., Hayano, Y., Hayakawa, H., Baba, K., Mochizuki, H. and Yamashita, T. (2019) Increased expression of fibronectin leucine-rich transmembrane protein 3 in the dorsal root ganglion induces neuropathic pain in rats. J. Neurosci.
  • Nakanishi, T., Fujita, Y. and Yamashita, T. (2019) Neuropilin-1-mediated pruning of corticospinal tract fibers is required for motor recovery after spinal cord injury. Cell Death Dis. 10, 67.
  • Nakagawa, H., Ninomiya, T., Yamashita, T. and Takada, M. (2019) Treatment with the neutralizing antibody against repulsive guidance molecule-a promotes recovery from impaired manual dexterity in a primate model of spinal cord injury. Cereb Cortex 29, 561-572.
  • Tanabe, S., Saitoh, S., Miyajima, H., Itokazu, T. and Yamashita, T. (2019) Microglia suppress the secondary progression of autoimmune encephalomyelitis. Glia 67, 1694-1704.
  • Tsujioka, H. and Yamashita, T. (2019) Comparison of gene expression profile of the spinal cord of sprouting-capable neonatal and sprouting-incapable adult mice. BMC Genomics 20, 619.
  • Hosomi, S., Koyama, Y., Watabe, T., Ohnishi, M., Ogura, H., Yamashita, T. and Shimazu, T. (2019) Myeloid-derived suppressor cells infiltrate the brain and suppress neuroinflammation in a mouse model of focal traumatic brain injury. Neuroscience 406, 457-466.
  • Nakanishi, T., Fujita, Y. and Yamashita, T. (2019) Anti-repulsive guidance molecule-a antibody treatment and repetitive transcranial magnetic stimulation have synergistic effects on motor recovery after spinal cord injury. Neurosci. Lett. 709, 134329.
  • Yamashita, T. (2019) Neogenin is a determining factor for regenerating neurons following spinal cord injury. Neurosci.
  • Fujita, Y. and Yamashita, T. (2019) The effects of leptin on glial cells in neurological diseases. Front. Neurosci. 13, 828.
  • Fujita, Y. and Yamashita, T. (2019) Roles of effector T cells in neurological autoimmunity. Neuroimmune Diseases-From cells to the living brain. Springer, p63-81.
  • Araki, T and Yamashita, T. (2019) Mechanism of neuroaxonal degeneration: from molecular signaling to therapeutic applications. Neurosci. Res. 139, 1-2.
  • Tanabe, S. and Yamashita, T. (2019) B lymphocytes: crucial contributors to brain development and neurological diseases. Neurosci. Res. 139, 37-41.
  • 山下俊英: 中枢神経回路の修復機構と生体システム連関、実験医学増刊号「臓器連環による動的恒常性とその破綻 〜疾患発祥のメカニズムに迫る!」、羊土社、37, 1205-1211, 2019
  • 山下俊英: 中枢神経疾患における適応・修復機構、別冊BIO Clinica 慢性炎症と疾患、北隆館、8: 61-64, 2019
  • 山下俊英: 中枢神経障害からの回復研究の現状と未来、実験医学特集「最も修復しにくい臓器 中枢神経を再生せよ!」、実験医学、羊土社、37: 2098-2103, 2019
  • 山下俊英: 軸索再生阻害因子を標的とする神経回路修復治療薬の開発、実験医学特集「最も修復しにくい臓器 中枢神経を再生せよ!」、実験医学、羊土社、37: 2129-2134, 2019
  • 山下俊英: 中枢神経回路の修復を促進する抗体治療薬の開発、『再生医療最前線〜リハビリテーションへの応用、The Japanese Journal of Rehabilitation Medicine: 56, 702-705, 2019
2018年 2024年2023年2022年2021年2020年2019年|2018年|2017年(2016年以前→)
  • Tanabe, S. and Yamashita, T. (2018) B-1a lymphocytes promote oligodendrogenesis during brain development. Nat. Neurosci.21, 506-516.
    田辺章悟、山下俊英:B-1a細胞は脳発達期においてオリゴデンドロサイトの成熟を促進する、ライフサイエンス 新着論文レビュー、2018
  • Kawakami, Y., Kurihara, Y., Saito, Y., Fujita, Y., Yamashita, T. and Takei, K. (2018) The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor. J. Neurosci. 38, 2589-2604.
  • Zhang, S., Fujita, Y., Matsuzaki, R. and Yamashita, T. (2018) Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury. Cell Death Dis. 9,460.
  • Tanabe, S., Fujita, Y., Ikuma, K. and Yamashita, T. (2018) Inhibiting
    repulsive guidance molecule A suppresses secondary progression in mouse
    models of multiple sclerosis. Cell Death Dis. 9, 1061.
  • Lin, H., Muramatsu, R., Maedera, N., Tsunematsu, H., Hamaguchi, M., Koyama, Y., Kuroda, M., Ono, K., Sawada, M. and Yamashita, T. (2018) Extracellular lactate dehydrogenase A release from damaged neurons drives central nervous system angiogenesis. EBiomedicine 27, 71-85. 
  • Harada, K., Fujita, Y., Okuno, T., Tanabe, S., Koyama, Y., Mochizuki, H. and Yamashita, T. (2018) Inhibition of RGM alleviates symptoms in a rat model of neuromyelitis optica. Sci. Rep. 8, 34.
  • Nishibe, M., Katsuyama, Y. and Yamashita, T. (2018) Developmental abnormality contributes to cortex-dependent motor impairments and higher intracortical current requirement in the reeler homozygous mutants. Brain Structure and Function
  • Csoka, B., Nemeth, Z., Szabo, I., Davies, D., Varga, Z., Paloczi, J., Falzoni, S., Virgilio, F. D., Muramatsu, R., Yamashita, T., Pacher, P and Hasko, G. (2018) Macrophage P2X4 receptors augment bacterial killing and protect against sepsis. JCI Insight 3, e99431.
  • Abe, Y., Honsho, M.,Kawaguchi, R., Itoh, R., Fujitani, M., Fujiwara, K.,
    Hirokane, M., Matsuzaki,T., Nakayama, K., Muratani, T., Nakayama, K.I.,
    Yamashita, T. and Fujiki, Y. (2018) Peroxisome biogenesis deficiency
    attenuates the BDNF-TrkB pathway-mediated development of cerebellum. Life Sci. Alliance 1, e201800062.
  • Fukunaga, T., Fujita, Y., Kishima, H. and Yamashita, T. (2018) Methylation
    dependent down-regulation of G0S2 leads to suppression of invasion and improved prognosis of IDH1-mutant glioma. PLoS ONE 13, e0206552.
  • Nakasone, A., Muramatsu, R., Kato, Y., Kawahara, Y. and Yamashita, T. (2018) Myotube-derived factor promotes oligodendrocyte precursor cell proliferation. Biochem. Biophys. Res. Commun. 500, 609-613.
  • Hosomi, S., Watabe, T., Mori, Y., Koyama, Y., Adachi, S., Hoshi, N., Ohnishi, M., Ogura, H., Yoshioka, Y., Hatazawa, J., Yamashita, T. and Shimazu, T. (2018) Inflammatory projections after focal brain injury trigger neuronal network disruption. Neuroimage: Clinical 20, 946-954. 
  • Fujita, Y. and Yamashita, T. (2018) Sirtuins in Neuroendocrine Regulation and Neurological Diseases. Front. Neurosci. 12, 778.
  • Fujita, Y. and Yamashita, T. (2017) Spatial organization of genome architecture in neural development and disease. Neurochem. Int. 119, 49-56.
  • Tanabe, S. and Yamashita, T. (2018) The role of immune cells in brain development and neurodevelopmental diseases. Int. Immunol. 30, 437-444.
  • 山下俊英:中枢神経回路の修復、脳卒中病態学のススメ、南山堂、p26-28, 2018
  • 藤田幸、山下俊英:多発性硬化症における動物モデルの作製手法、最新の疾患/動物モデルの作成技術と病態解析,医薬品開発への応用、最新のゲノム編集/iPS細胞を含めた〜動物/疾患モデルの作成技術・病態解析・評価手法、株式会社 技術情報協会.
  • 藤田幸、山下俊英:多発性硬化症の最新メカニズム,創薬への応用と動物試験の評価指標、最新の疾患/動物モデルの作成技術と病態解析,医薬品開発への応用、最新のゲノム編集/iPS細胞を含めた〜動物/疾患モデルの作成技術・病態解析・評価手法、株式会社 技術情報協会.
  • 山下俊英:中枢神経回路の障害と修復を制御する生体システム、炎症と免疫、先端医学社、26: 171-174, 2018
  • 山下俊英:中枢神経回路の修復を制御する生体システム、関西実験動物研究会会報、39, 6-8,2018
  • 山下俊英: 中枢神経回路の修復を制御する生体システム、医学のあゆみ、266: 294-295, 2018
  • 村松里衣子、山下俊英: 中枢神経系の修復における多臓器連関の意義、生化学、日本生化学会、90: 499-501, 2018
2017年 2024年2023年2022年2021年2020年2019年2018年|2017年|(2016年以前→)
  • Fujitani, M., Zhang, S., Fujiki, R., Fujihara, Y. and Yamashita, T. (2017) A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling. Mol. Psychiatry 22, 364-374.
    神経発達障害群の染色体重複による発症の機序を解明しました。
    http://www.nature.com/doifinder/10.1038/mp.2016.106
    論文内容の日本語での紹介は下記サイト。
    http://resou.osaka-u.ac.jp/ja/research/2016/20160705_1
    医学系研究科の主要研究成果
    http://www.med.osaka-u.ac.jp/jpn/activities/results/2016/006
  • Kuroda, M., Muramatsu, R., Maedera, N., Koyama, Y., Hamaguchi, M., Fujimura, H., Yoshida, M., Konishi, M., Itoh, N., Mochizuki, H. and Yamashita, T. (2017) Peripherally derived FGF21 promotes remyelination in the central nervous system. J. Clin. Invest.
    脳脊髄の外部の分子が、脳脊髄の髄鞘修復を促すことを発見しました。
    https://www.jci.org/articles/view/94337
    大阪大学ホームページ
    https://resou.osaka-u.ac.jp/ja/research/2017/20170822_1               大阪大学/JSTからのプレスリリース        http://www.jst.go.jp/pr/announce/20170822-3/index.html
  • Fujita, Y., Masuda, K., Bando, M., Nakato, R., Katou, Y., Tanaka, T., Nakayama, M., Takao, K., Miyakawa, T., Tanaka, T., Ago, Y., Hashimoto, H., Shirahige, K. and Yamashita, T.(2017) Decreased cohesin in the brain leads to defective synapse development and anxiety-related behavior. J. Exp. Med.214, 1431-1452.
    コヒーシンの機能低下により不安行動が高まるメカニズムを解明しました。
    医学系研究科の主要研究成果
  • Siebold, C., Yamashita, T., Monnier, P., Mueller, B.K. and Pasterkamp, R.J. (2017) RGMs: Structural Insights, Molecular Regulation and Downstream Signaling. Trends Cell Biol. 27, 365-378.
  • van Battum, E.Y., Verhagen, M.G., Vangoor, V., Fujita, Y., Derijck, A.A.H.A., EO’Duibhir, E., Giuliani, G., de Gunst, G., Adolfs, Y., Lelieveld, D., Egan, D., Schaapveld, R., Yamashita, T. and Pasterkamp, R.J. (2017) An image-based miRNA screen identifies miRNA-135s as regulators of CNS axon growth and regeneration by targeting Kruppel-like Factor 4. J. Neurosci.
  • Ishizuka, K., Fujita, Y., Kawabata, T., Kimura, H., Iwayama, Y., Inada, T., Okahisa, Y., Egawa, J. Usami, M., Kushima, I., Uno, Y., Okada, T., Ikeda, M., Aleksic, B., Mori, D., Someya, T. Yoshikawa, T., Iwata, N., Nakamura, H., Yamashita, T. and Ozaki, N.(2017)Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders.Transl. Psychiatry7, e1184.
  • Kimura, H., Fujita, Y., Kawabata, T., Ishizuka,K., Wang, C., Iwayama, Y., Okahisa, Y., Kushima, I., Morikawa, M., Uno, Y., Okada, T., Ikeda, M., Inada,T.,Branko, A.,Mori, D.,Yoshikawa, T., Iwata, N., Nakamura, H.,Yamashita, T.and Ozaki, N. (2017) A novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to Schizophrenia susceptibility.Transl. Psychiatry
  • Fujitani, M., Sato, R. and Yamashita, T. (2017) Loss of p73 in ependymal cells during the perinatal period leads to aqueductal stenosis. Sci. Rep. 7, 12007.
  • Kanemitsu, Y., Fujitani, M., Fujita, Y., Zhang, S., Su, Y.Q., Kawahara, Y. and Yamashita, T. (2017) The RNA-binding protein MARF1 promotes cortical neurogenesis through its RNase activity domain. Sci. Rep. 7, 1155.
  • Matoba, K., Muramatsu, R. and Yamashita, T. (2017) Leptin sustains spontaneous remyelination in the adult central nervous system. Sci. Rep. 7, 40397.
  • Kawai, T., Okochi, Y., Ozaki, T., Imura, Y., Koizumi, S., Yamazaki, M., Abe, M., Sakimura, K., Yamashita, T. and Okamura, Y. (2017)Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.J. Neurochem.
  • Fujita, Y. and Yamashita, T. (2017) The roles of RGMa-neogenin signaling in inflammation and angiogenesis. Inflammation and Regeneration 37, 6.
  • Fujita, Y. and Yamashita, T.(2017) Spatial organization of genome architecture in neural development and disease.Neurochem. Int.
  • Matoba, K., Muramatsu, R. and Yamashita, T. (2017) The role of leptin in the central nervous system remyelination. Receptors & Clinical Investigation.
  • Hamaguchi, M., Muramatsu, R., Matoba, K., Maedera, N., Yamashita, T.(2017) Lysophosphatidylcholine-induced demyelination model of mouse. Protocol Exchange
  • 山下俊英: 痛みをなくすことはできるのか?-疼痛関連因子“ネトリン”の発見、academist Journal, 2017.
    https://academist-cf.com/journal/?p=3319
  • 濱口真慈、村松里衣子、山下俊英:ミエリン、脳内環境辞典、88-89, 2017
以前の業績はこちら
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