大阪大学 大学院医学系研究科 放射線統合医学講座 核医学 ／ 大阪大学医学部附属病院 核医学診療科

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  2. 教室紹介
  3. 業績
  4. 2014－2011年

2014－2011年

2014年

  1. Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y. 11C-Acetate PET Imaging in Patients with Multiple Sclerosis. PLoS One. 2014 Nov 4;9(11):e111598.
  2. Sakane M, Tatsumi M, Kim T, Hori M, Onishi H, Nakamoto A, Eguchi H, Nagano H, Wakasa K, Hatazawa J, Tomiyama N. Correlation between apparent diffusion coefficients on diffusion-weighted MRI and standardized uptake value on FDG-PET/CT in pancreatic adenocarcinoma. Acta Radiol. 2014 Sep 29. (in press)
  3. Watabe T, Naka S, Ikeda H, Horitsugi G, Kanai Y, Isohashi K, Ishibashi M, Kato H, Shimosegawa E, Watabe H, Hatazawa J. Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat. PLoS One. 2014 Sep 16;9(9):e107427.
  4. Yamamoto S, Hamamura F, Watabe T, Ikeda H, Kanai Y, Watabe H, Kato K, Ogata Y, Hatazawa J. Development of a PET/Cerenkov-light hybrid imaging system. Med Phys. 2014 Sep;41(9):092504.
  5. Yamamoto S, Watabe T, Ikeda H, Kanai Y, Watabe H, Ogata Y, Kato K, Hatazawa J. Ultrahigh-resolution Cerenkov-light imaging system for positron radionuclides: potential applications and limitations. Ann Nucl Med. 2014 Aug 8. (in press)
  6. Watabe T, Shimosegawa E, Kato H, Isohashi K, Ishibashi M, Tatsumi M, Kitagawa K, Fujinaka T, Yoshimine T, Hatazawa J. Paradoxical reduction of cerebral blood flow after acetazolamide loading: a hemodynamic and metabolic study with (15)O PET. Neurosci Bull. 2014 Oct;30(5):845-56.
  7. Watabe T, Shimosegawa E, Kato H, Isohashi K, Ishibashi M, Hatazawa J. CBF/CBV maps in normal volunteers studied with (15)O PET: a possible index of cerebral perfusion pressure. Neurosci Bull. 2014 Oct;30(5):857-62.
  8. Hanamoto A, Tatsumi M, Takenaka Y, Hamasaki T, Yasui T, Nakahara S, Yamamoto Y, Seo Y, Isohashi F, Ogawa K, Hatazawa J, Inohara H. Volumetric PET/CT parameters predict local response of head and neck squamous cell carcinoma to chemoradiotherapy. Cancer Med. 2014 Oct;3(5):1368-76.
  9. Yamauchi M, Imabayashi E, Matsuda H, Nakagawara J, Takahashi M, Shimosegawa E, Hatazawa J, Suzuki M, Iwanaga H, Fukuda K, Iihara K, Iida H. Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of (123)I-iodoamphetamine: comparison among data acquired at three institutions. Ann Nucl Med. 2014 Jul 8. (in press)
  10. Hosono M, Saga T, Ito K, Kumita S, Sasaki M, Senda M, Hatazawa J, Watanabe H, Ito H, Kanaya S, Kimura Y, Saji H, Jinnouchi S, Fukukita H, Murakami K, Kinuya S, Yamazaki J, Uchiyama M, Uno K, Kato K, Kawano T, Kubota K, Togawa T, Honda N, Maruno H, Yoshimura M, Kawamoto M, Ozawa Y. Clinical practice guideline for dedicated breast PET. Ann Nucl Med. 2014 Jul;28(6):597-602.
  11. Tamura M, Matsui H, Hirohara S, Kakiuchi K, Tanihara M, Takahashi N, Nakai K, Kanai Y, Watabe H, Hatazawa J. Selective accumulation of [?²Zn]-labeled glycoconjugated porphyrins as multi-functional positron emission tomography tracers in cancer cells. Bioorg Med Chem. 2014 Apr 15;22(8):2563-70.
  12. Tsuboyama T, Tatsumi M, Onishi H, Nakamoto A, Kim T, Hori M, Sakane M, Hori Y, Morii E, Hatazawa J, Tomiyama N. Assessment of combination of contrast-enhanced magnetic resonance imaging and positron emission tomography/computed tomography for evaluation of ovarian masses. Invest Radiol. 2014 Aug;49(8):524-31.
  13. Yamamoto S, Watabe H, Kanai Y, Kato K, Hatazawa J. Development of a high-resolution YSO gamma camera system that employs 0.8-mm pixels. Ann Nucl Med. 2014 Apr;28(3):232-40.
  14. Miyata H, Yamasaki M, Takahashi T, Murakami K, Tanaka K, Yukinori K, Nakajima K, Takiguchi S, Morii E, Hatazawa J, Mori M, Doki Y. Determinants of response to neoadjuvant chemotherapy for esophageal cancer using 18F-fluorodeoxiglucose positron emission tomography (18F-FDG-PET). Ann Surg Oncol. 2014 Feb;21(2):575-82.

2013年

  1. Yamamoto S, Watabe H, Kanai Y, Watabe T, Kato K, Hatazawa J. Development of an ultrahigh resolution Si-PM based PET system for small animals. Phys Med Biol. 2013 Nov 7;58(21):7875-88.
  2. Ito K, Mori E, Fukuyama H, Ishii K, Washimi Y, Asada T, Mori S, Meguro K, Kitamura S, Hanyu H, Nakano S, Matsuda H, Kuwabara Y, Hashikawa K, Momose T, Uchida Y, Hatazawa J, Minoshima S, Kosaka K, Yamada T, Yonekura Y; J-COSMIC Study Group. Prediction of outcomes in MCI with 123I-IMP-CBF SPECT: a multicenter prospective cohort study. Ann Nucl Med. 2013 Dec;27(10):898-906.
  3. Hanamoto A, Takenaka Y, Shimosegawa E, Ymamamoto Y, Yoshii T, Nakahara S, Hatazawa J, Inohara H. Limitation of 2-deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) to detect early synchronous primary cancers in patients with untreated head and neck squamous cell cancer. Ann Nucl Med. 2013 Dec;27(10):880-5.
  4. Toita R, Kanai Y, Watabe H, Nakao K, Yamamoto S, Hatazawa J, Akashi M. Biodistribution of (125)I-labeled polymeric vaccine carriers after subcutaneous injection. Bioorg Med Chem. 2013 Sep 1;21(17):5310-5.
  5. Shimosegawa E, Fujino K, Kato H, Hatazawa J. Quantitative CBF measurement using an integrated SPECT/CT system: validation of three-dimensional ordered-subset expectation maximization and CT-based attenuation correction by comparing with O-15 water PET. Ann Nucl Med. 2013 Nov;27(9):822-33.
  6. Hosoya T, Hatazawa J, Sato S, Kanoto M, Fukao A, Kayama T. Floating Dural Sac Sign is a Sensitive Magnetic Resonance Imaging Finding of Spinal Cerebrospinal Fluid Leakage. Neurol Med Chir (Tokyo). 2013;53(4):207-12.
  7. Isohashi K, Shimosegawa E, Kato H, Kanai Y, Naka S, Fujino K, Watabe H, Hatazawa J. Optimization of [11C]methionine PET study: appropriate scan timing and effect of plasma amino acid concentrations on the SUV. EJNMMI Res. 2013 Apr 15;3(1):27.
  8. Watabe T, Shimosegawa E, Watabe H, Kanai Y, Hanaoka K, Ueguchi T, Isohashi K, Kato H, Tatsumi M, Hatazawa J. Quantitative Evaluation of Cerebral Blood Flow and Oxygen Metabolism in Normal Anesthetized Rats: 15O-Labeled Gas Inhalation PET with MRI Fusion. J Nucl Med. 2013 Feb;54(2):283-90.
  9. Hosomi K, Kishima H, Oshino S, Hirata M, Tani N, Maruo T, Khoo HM, Shimosegawa E, Hatazawa J, Kato A, Yoshimine T. Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy. Epilepsy Res. 2013 Feb;103(2-3):195-204.

2012年

  1. Yamamoto S, Watabe H, Kato K, Hatazawa J. Performance comparison of high quantum efficiency and normal quantum efficiency photomultiplier tubes and position sensitive photomultiplier tubes for high resolution PET and SPECT detectors. Med Phys. 2012 Nov;39(11):6900-7.
  2. Yamamoto S, Watabe H, Kanai Y, Watabe T, Aoki M, Sugiyama E, Kato K, Hatazawa J. Development of a flexible optical fiber based high resolution integrated PET／MRI system. Med Phys. 2012 Nov;39(11):6660-71.
  3. Kinoshita M, Arita H, Goto T, Okita Y, Isohashi K, Watabe T, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T. A novel PET index, 18F-FDG-11C-methionine uptake decoupling score, reflects glioma cell infiltration. J Nucl Med. 2012 Nov;53(11):1701-8.
  4. Nomura K, Kazui H, Wada T, Sugiyama H, Yamamoto D, Yoshiyama K, Shimosegawa E, Hatazawa J, Takeda M. Classification of delusions in Alzheimer's disease and their neural correlates. Psychogeriatrics. 2012 Sep;12(3):200-10.
  5. Hosomi K, Kishima H, Oshino S, Hirata M, Tani N, Maruo T, Khoo HM, Shimosegawa E, Hatazawa J, Kato A, Yoshimine T. Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy. Epilepsy. 2013 Feb;103(2-3):195-204.
  6. Fujiwara S, Wada H, Miyata H, Kawada J, Kawabata R, Nishikawa H, Gnjatic S, Sedrak C, Sato E, Nakamura Y, Sakakibara M, Kanto T, Shimosegawa E, Hatazawa J, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Nakayama E, Mori M, Doki Y. Clinical trial of the intratumoral administration of labeled DC combined with systemic chemotherapy for esophageal cancer. J Immunother. 2012 Jul;35(6):513-21.
  7. Kato H, Matsuda K, Baba K, Shimosegawa E, Isohashi K, Imaizumi M, Hatazawa J. MR imaging-based correction for partial volume effect improves detectability of intractable epileptogenic foci on iodine 123 iomazenil brain SPECT images: an extended study with a larger sample size. AJNR Am J Neuroradiol. 2012 Dec;33(11):2088-94.
  8. Yanagawa M, Tatsumi M, Miyata H, Morii E, Tomiyama N, Watabe T, Isohashi K, Kato H, Shimosegawa E, Yamasaki M, Mori M, Doki Y, Hatazawa J. Evaluation of response to neoadjuvant chemotherapy for esophageal cancer: PET response criteria in solid tumors versus response evaluation criteria in solid tumors. J Nucl Med. 2012 Jun;53(6):872-80.
  9. Fujibuchi T, Horitsugi G, Yamaguchi I, Eto A, Iwamoto Y, Obara S, Iimori T, Masuda Y, Watanabe H, Hatazawa J. Comparison of neutron fluxes in an 18-MeV unshielded cyclotron room and a 16.5-MeV self-shielded cyclotron room. Radiol Phys Technol. 2012 Jul;5(2):156-65.
  10. Kato H, Shimosegawa E, Isohashi K, Kimura N, Kazui H, Hatazawa J. Distribution of cortical benzodiazepine receptor binding in right-handed healthy humans: a voxel-based statistical analysis of iodine 123 iomazenil SPECT with partial volume correction. AJNR Am J Neuroradiol. 2012 Sep;33(8):1458-63.
  11. Horitsugi G, Fujibuchi T, Yamaguchi I, Eto A, Iwamoto Y, Hashimoto H, Hamada S, Obara S, Watanabe H, Hatazawa J. Radiologic assessment of a self-shield with boron-containing water for a compact medical cyclotron. Radiol Phys Technol. 2012 Jul;5(2):129-37.
  12. Tatsumi M, Yamamoto S, Imaizumi M, Watabe T, Kanai Y, Aoki M, Kato H, Shimosegawa E, Hatazawa J. Simultaneous PET/MR body imaging in rats: initial experiences with an integrated PET/MRI scanner. Ann Nucl Med. 2012 Feb:26(5):444-449.
  13. Yamamoto S, Watabe H, Kanai Y, Shimosegawa E, Hatazawa J. Development of a pixelated GSO gamma camera system with tungsten parallel hole collimator for single photon imaging. Med Phys. 2012 Feb;39(2):581.
  14. Koshino K, Watabe H, Enmi J, Hirano Y, Zeniya T, Hasegawa S, Hayashi T, Miyagawa S, Sawa Y, Hatazawa J, Iida H. Effects of patient movement on measurements of myocardial blood flow and viability in resting (15)O-water PET studies. J Nucl Cardiol. 2012 Jun;19(3):524-33.
  15. Watabe T, Tatsumi M, Watabe H, Isohashi K, Kato H, Yanagawa M, Shimosegawa E, Hatazawa J. Intratumoral heterogeneity of F-18 FDG uptake differentiates between gastrointestinal stromal tumors and abdominal malignant lymphomas on PET/CT. Ann Nucl Med. 2012 Apr;26(3):222-7.
  16. Chiba Y, Kinoshita M, Okita Y, Tsuboi A, Isohashi K, Kagawa N, Fujimoto Y, Oji Y, Oka Y, Shimosegawa E, Morita S, Hatazawa J, Sugiyama H, Hashimoto N, Yoshimine T. Use of (11)C-methionine PET parametric response map for monitoring WT1 immunotherapy response in recurrent malignant glioma. J Neurosurg. 2012 Apr;116(4):835-42.
  17. Yamamoto S, Watabe T, Watabe H, Aoki M, Sugiyama E, Imaizumi M, Kanai Y, Shimosegawa E, Hatazawa J. Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MRI system. Phys Med Biol. 2012 Jan 21;57(2):N1-13.
  18. Arita H, Kinoshita M, Okita Y, Hirayama R, Watabe T, Ishohashi K, Kijima N, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T. Clinical characteristics of meningiomas assessed by (11)C-methionine and (18)F-fluorodeoxyglucose positron-emission tomography. J Neurooncol. 2012 Apr;107(2):379-86.
  19. Kimura Y, Siméon FG, Zoghbi SS, Zhang Y, Hatazawa J, Pike VW, Innis RB, Fujita M. Quantification of metabotropic glutamate subtype 5 receptors in the brain by an equilibrium method using 18F-SP203. Neuroimage. 2012 Feb 1;59(3):2124-30.
  20. Takahashi R, Hirata H, Tachibana I, Shimosegawa E, Inoue A, Nagatomo I, Takeda Y, Kida H, Goya S, Kijima T, Yoshida M, Kumagai T, Kumanogoh A, Okumura M, Hatazawa J, Kawase I. Early [18F]fluorodeoxyglucose positron emission tomography at two days of gefitinib treatment predicts clinical outcome in patients with adenocarcinoma of the lung. Clin Cancer Res. 2012 Jan 1;18(1):220-8.
  21. Yamamoto S, Watabe H, Kanai Y, Watabe T, Imaizumi M, Shimosegawa E, Hatazawa J. Development of a high-sensitivity BGO well counter for small animal PET studies. Radiol Phys Technol. 2012 Jan;5(1):59-62.
  22. Kinoshita M, Goto T, Arita H, Okita Y, Isohashi K, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Saitoh Y, Hatazawa J, Hashimoto N, Yoshimine T. Imaging ¹?F-fluorodeoxy glucose/¹¹C-methionine uptake decoupling for identification of tumor cell infiltration in peritumoral brain edema. J Neurooncol. 2012 Jan;106(2):417-25.
  23. Yasuda T, Higuchi I, Yano M, Miyata H, Yamasaki M, Takiguchi S, Fujiwara Y, Hatazawa J, Doki Y. The impact of (18)f-fluorodeoxyglucose positron emission tomography positive lymph nodes on postoperative recurrence and survival in resectable thoracic esophageal squamous cell carcinoma. Ann Surg Oncol. 2012 Feb;19(2):652-60.

2011年

  1. Watabe T, Tatsumi M, Watabe H, Isohashi K, Kato H, Yanagawa M, Shimosegawa E, Hatazawa J. Intratumoral heterogeneity of F-18 FDG uptake differentiates between gastrointestinal stromal tumors and abdominal malignant lymphomas on PET/CT. Ann Nucl Med. 2011 Dec 21.  [Epub ahead of print]
  2. Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M. Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer's disease in the mild cognitive impairment stage. Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):20-30.
  3. Yamamoto S, Hatazawa J. Development of an alpha／beta／gamma detector for radiation monitoring. Rev Sci Instrum. 2011 Nov;82(11):113503.
  4. Arita H, Kinoshita M, Okita Y, Hirayama R, Watabe T, Ishohashi K, Kijima N, Kagawa N, Fujimoto Y, Kishima H, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T. Clinical characteristics of meningiomas assessed by (11)C-methionine and (18)F-fluorodeoxyglucose positron-emission tomography. J Neurooncol. 2011 Nov 17. [Epub ahead of print]
  5. Yamamoto S, Watabe H, Kanai Y, Imaizumi M, Watabe T, Shimosegawa E, Hatazawa J. Development of a high-resolution Si-PM-based gamma camera system. Phys Med Biol. 2011 Dec 7;56(23):7555-67.
  6. Hatazawa J. Cancer screening by FDG-PET: benefit or risk? Ann Nucl Med. 2011 Nov;25(9):667-8.
  7. Yamamoto S, Watabe H, Hatazawa J. Performance comparison of Si-PM-based block detectors with different pixel sizes for an ultrahigh-resolution small-animal PET system. Phys Med Biol. 2011 Oct 21;56(20):N227-36.
  8. Kubota K, Murakami K, Inoue T, Itoh H, Saga T, Shiomi S, Hatazawa J. Additional value of FDG-PET to contrast enhanced-computed tomography (CT) for the diagnosis of mediastinal lymph node metastasis in non-small cell lung cancer: a Japanese multicenter clinical study. Ann Nucl Med. 2011 Dec;25(10):777-86.
  9. Yamamoto S, Watabe H, Kanai Y, Aoki M, Sugiyama E, Watabe T, Imaizumi M, Shimosegawa E, Hatazawa J. Interference between PET and MRI sub-systems in a silicon-photomultiplier-based PET/MRI system. Phys Med Biol. 2011 Jul 7;56(13):4147-59.
  10. Yamamoto S, Satomi J, Watabe T, Watabe H, Kanai Y, Imaizumi M, Shimosegawa E, Hatazawa J. A temperature-dependent gain control system for improving the stability of Si-PM-based PET systems. Phys Med Biol. 2011 May 7;56(9):2873-82.
  11. Yoshida T, Kazui H, Tokunaga H, Kito Y, Kubo Y, Kimura N, Morihara T, Shimosegawa E, Hatazawa J, Takeda M. Protein synthesis in the posterior cingulate cortex in Alzheimer's disease. Psychogeriatrics. 2011 Mar;11(1):40-5.
  12. Tatsumi M, Isohashi K, Onishi H, Hori M, Kim T, Higuchi I, Inoue A, Shimosegawa E, Takeda Y, Hatazawa J. (18)F-FDG PET/MRI fusion in characterizing pancreatic tumors: comparison to PET/CT. Int J Clin Oncol. 2011 Aug;16(4):408-15.
  13. Kobayashi S, Nagano H, Hoshino H, Wada H, Marubashi S, Eguchi H, Takeda Y, Tanemura M, Kim T, Shimosegawa E, Hatazawa J, Doki Y, Mori M. Diagnostic value of FDG-PET for lymph node metastasis and outcome of surgery for biliary cancer. J Surg Oncol. 2011 Mar 1;103(3):223-9.