3) Molecular Imaging
Oncology Imaging

Glucose metabolism imaging by FDG-PET is widely used in cancer diagnostics, but false positive finding in inflammatory tissues is a problem. In preclinical studies using animal models, it was shown that amino acid PET probes (F-18 FBPA and C-11 methionine), unlike FDG-PET, are less likely to accumulate on inflammation. ¹⁾
In prostate-specific membrane antigen (PSMA) PET, physiological accumulation can be reduced in the salivary glands by optimizing the PSMA-ligand concentration, while maintaining tumor accumulation. The salivary glands are risk organs in the treatment of α-ray nuclide actinium (Ac-225) - PSMA therapy, and our study showed a new concept of reducing side effects in alpha therapy targeting PSMA. ²⁾
In hypoxic areas within tumors, which are reported to be resistant to radiation therapy and chemotherapy, tumor blood flow was decreased and oxygen extraction fraction tended to increase. ³⁾

1) Watabe T, et al. EJNMMI. 2017.
2) Soeda F, et al. J Nucl Med. 2019.
3) Watabe T, et al. EJNMMIR. 2017.