3) Molecular Imaging
Myocardial perfusion and metabolic imaging

Ammonia (¹³N-NH₃) PET enables quantitative evaluation of myocardial blood flow. In joint research with cardiovascular surgery group, we evaluated changes in blood flow using a myocardial infarction model in treatment with a myocardial sheet or a sustained-release drug sheet. ^1,2)
By using acetate (¹¹C-acetate) PET, myocardial oxygen consumption and oxygen consumption efficiency can be evaluated. In a myocardial infarction model, iPS cell myocardial sheet was shown to improve myocardial oxygen consumption efficiency. ³⁾

1) S.Kainuma et al. Molecular Therapy. 2014.
2) Yajima S, et al. J Thorac Cardiovasc Surg 2018.
3) Ishida M et al. Transplantation 2019.