阪大消化器内科のご紹介・研究実績



2008年

  1. Kurashige N, Hiramatsu N, Ohkawa K, Oze T, Inoue Y, Kurokawa M, Yakushijin T, Igura T, Kiso S, Kanto T, Takehara T, Tamura S, Kasahara A, Oshita M, Hijioka T, Katayama K, Yoshihara H, Hayashi E, Imai Y, Kato M, Hayashi N.
    Initial viral response is the most powerful predictor of the emergence of YMDD mutant virus in chronic hepatitis B patients treated with lamivudine.
    Hepatol Res. 38: 450-456, 2008.
  2. Hiramatsu N, Kurashige N, Oze T, Takehara T, Tamura S, Kasahara A, Oshita M, Katayama K, Yoshihara H, Imai Y, Kato M, Kawata S, Tsubouchi H, Kumada H, Okanoue T, Kakumu S, Hayashi N.
    Early decline of hemoglobin can predict progression of hemolytic anemia during pegylated interferon and ribavirin combination therapy in patients with chronic hepatitis C.
    Hepatol Res. 38: 52-59, 2008.
  3. Kanada A, Takehara T, Ohkawa K, Kato M, Tatsumi T, Miyagi T, Sakamori R, Yamaguchi S, Uemura A, Kohga K, Sasakawa A, Hikita H, Kawamura K, Kanto T, Hiramatsu N, Hayashi N.
    Early emergence of entecavir-resistant hepatitis B virus in a patient with hepatitis B virus/human immunodeficiency virus coinfection.
    Hepatol Res. 38: 622-628, 2008.
  4. Shinzaki S, Iijima H, Nakagawa T, Egawa S, Nakajima S, Ishii S, Irie T, Kakiuchi Y, Nishida T, Yasumaru M, Kanto T, Tsujii M, Tsuji S, Mizushima T, Yoshihara H, Kondo A, Miyoshi E, Hayashi N.
    IgG oligosaccharide alterations are a novel diagnostic marker for disease activity and the clinical course of inflammatory bowel disease.
    Am J Gastroenterol. 103: 1173-1181, 2008.
  5. Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Iijima H, Nakamura T, Eguchi H, Miyoshi E, Hayashi N, Kawano S.
    Topical transplantation of mesenchymal stem cells accelerates gastric ulcer healing in rats.
    Am J Physiol Gastrointest Liver Physiol. 294: G778-786, 2008.
  6. Murayama Y, Shinomura Y, Oritani K, Miyagawa J, Yoshida H, Nishida M, Katsube F, Shiraga M, Miyazaki T, Nakamoto T, Tsutsui S, Tamura S, Higashiyama S, Shimomura I, Hayashi N.
    The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells.
    J Cell Physiol. 216: 135-143, 2008.
  7. Nishida T, Tsuji S, Tsujii M, Ishii S, Yoshio T, Shinzaki S, Egawa S, Irie T, Kakiuchi Y, Yasumaru M, Iijima H, Tsutsui S, Kawano S, Hayashi N.
    Cultured bone marrow cell local implantation accelerates healing of ulcers in mice.
    J Gastroenterol. 43: 124-135, 2008.
  8. Yamamoto T, Watabe K, Nakahara M, Ogiyama H, Kiyohara T, Tsutsui S, Tamura S, Shinomura Y, Hayashi N.
    Disturbed gastrointestinal motility and decreased interstitial cells of Cajal in diabetic db/db mice.
    J Gastroenterol Hepatol. 23: 660-667, 2008.
  9. Horino J, Fujimoto M, Terabe F, Serada S, Takahashi T, Soma Y, Tanaka K, Chinen T, Yoshimura A, Nomura S, Kawase I, Hayashi N, Kishimoto T, Naka T.
    Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice.
    Int Immunol. 20: 753-762, 2008.
  10. Tanaka H, Imai Y, Hiramatsu N, Ito Y, Imanaka K, Oshita M, Hijioka T, Katayama K, Yabuuchi I, Yoshihara H, Inoue A, Kato M, Takehara T, Tamura S, Kasahara A, Hayashi N, Tsukuma H.
    Declining incidence of hepatocellular carcinoma in Osaka, Japan, from 1990 to 2003.
    Ann Intern Med. 148: 820-826, 2008.
  11. Miyazaki M, Kanto T, Inoue M, Itose I, Miyatake H, Sakakibara M, Yakushijin T, Kakita N, Hiramatsu N, Takehara T, Kasahara A, Hayashi N.
    Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I.
    J Med Virol. 80: 980-988, 2008.
  12. Nishihara T, Baba M, Matsuda M, Inoue M, Nishizawa Y, Fukuhara A, Araki H, Kihara S, Funahashi T, Tamura S, Hayashi N, Iishi H, Shimomura I.
    Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice.
    World J Gastroenterol. 2008;14:6473-80.
  13. Tatsumi T, Takehara T, Yamaguchi S, Sasakawa A, Yamamoto M, Fujita Y, Miyagi T, Ohkawa K, Hayashi N.
    Decreased expressions of CD1d molecule on liver dendritic cells in subcutaneous tumor bearing mice.
    J Hepatol. 2008;49:779-86.
  14. Kohga K, Takehara T, Tatsumi T, Ohkawa K, Miyagi T, Hiramatsu N, Kanto T, Kasugai T, Katayama K, Kato M, Hayashi N.
    Serum levels of soluble major histocompatibility complex (MHC) class I-related chain A in patients with chronic liver diseases and changes during transcatheter arterial embolization for hepatocellular carcinoma.
    Cancer Sci. 2008;99:1643-9.
  15. Ohkawa K, Takehara T, Kato M, Deguchi M, Kagita M, Hikita H, Sasakawa A, Kohga K, Uemura A, Sakamori R, Yamaguchi S, Miyagi T, Ishida H, Tatsumi T, Hayashi N.
    Supportive role played by precore and preS2 genomic changes in the establishment of lamivudine-resistant hepatitis B virus.
    J Infect Dis. 2008 ;198:1150-8.
  16. Egawa S, Iijima H, Shinzaki S, Nakajima S, Wang J, Kondo J, Ishii S, Yoshio T, Irie T, Nishida T, Kakiuchi Y, Yasumaru M, Yoshihara H, Kanto T, Tsujii M, Tsuji S, Hayashi N.
    Upregulation of GRAIL is associated with remission of ulcerative colitis.
    Am J Physiol Gastrointest Liver Physiol. 2008;295:G163-G169.
  17. Hayashi Y, Tsuji S, Tsujii M, Nishida T, Ishii S, Iijima H, Nakamura T, Eguchi H, Miyoshi E, Hayashi N, Kawano S.
    Topical implantation of mesenchymal stem cells has beneficial effects on healing of experimental colitis in rats.
    J Pharmacol Exp Ther. 2008;326:523-31.
  18. Yamaguchi S, Tatsumi T, Takehara T, Sasakawa A, Hikita H, Kohga K, Uemura A, Sakamori R, Ohkawa K, Hayashi N.
    Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity.
    Cancer Immunol Immunother. 2008;57:1861-9.
  19. Toyama T, Hiramatsu N, Yakushijin T, Oze T, Nakanishi F, Yasumaru M, Mochizuki K, Kanto T, Takehara T, Kasahara A, Hayashi N.
    A new prognostic system for hepatocellular carcinoma including recurrent cases: a study of 861 patients in a single institution.
    J Clin Gastroenterol. 2008 ;42:317-22.