阪大消化器内科のご紹介・研究実績



2009年

  1. Kamada Y, Yoshida Y, Saji Y, Fukushima J, Tamura S, Kiso S, Hayashi N.
    Transplantation of basic fibroblast growth factro-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice.
    Am J Physiol Gastrointest Liver Physiol 296:G157-G167, 2009
  2. Ezaki H, Yoshida Y, Saji Y, Takemura T, Fukushima J, Matsumoto H, Kamada Y, Wada A, Igura T, Kihara S, Funahashi T, Shimomura I, Tamura S, Kiso S, Hayashi N.
    Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice.
    Biochem Biophys Res Commun 378:68-72, 2009
  3. Itose I, Kanto T, Kakita N, Takebe S, Inoue M, Higashitani K, Miyazaki M, Miyatake H, Sakakibara M, Hiramatsu N, Takehara T, Kasahara A, Hayashi N.
    Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis.
    J Viral Hepat 16:844-852,2009
  4. Kurokawa M, Hiramatsu N, Oze T, Mochizuki K, Yakushijin T, Kurashige N, Inoue Y, Igura T, Imanaka K, Yamada A, Oshita M, Hagiwara H, Mita E, Ito T, Inui Y, Hijioka T, Yoshihara H, Inoue A, Imai Y, Kato M, Kiso S, Kanto T, Takehara T, Kasahara A, Hayashi N.
    Effect of inteferon α-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with chronic hepatitis.
    Hepatol Res 39:432-438, 2009
  5. Kurashige N, Hiramatsu N, Ohkawa K, Yakushijin T, Kiso S, Kanto T, Takehara T, Kasahara A, Doi Y, Yamada A, Oshita M, Mita E, Hagiwara H, Nagase T, Yoshihara H, Hayashi E, Imai Y, Kato M, Kashihara T, Hayashi N.
    Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B.
    J Gastroenterol 44:601-607, 2009
  6. Sasakawa A, Tatsumi T, Takehara T, Yamaguchi S, Yamamoto M, Ohkawa K, Miyagi T, Hayashi N.
    Activated liver dendritic cells generate strong acquired immunity in alpha-galactosylceramide treatment.
    J Hepatol 50:1155-1162, 2009
  7. Ohkawa K, Takehara T, Kato M, Kanada A, Deguchi M, Kagita M, Hikita H, Sasakawa A, Kohga K, Uemura A, Sakamori R, Yamaguchi S, Miyagi T Ishida H, Tatsumi T, Hayashi N.
    Mutations assiciated with the therapeutic efficacy of adefovir dipivoxil added to lamivudine in patients resistant to lamivudine with type B chronic hepatitis.
    J Med Virol 81:798-806, 2009
  8. Moriwaki K, Noda K, Fukukawa Y, Ohshima K, Uchiyama A, Nakagawa T, Taniguchi N, Daigo Y, Nakamura Y, Hayashi N, Miyoshi E.
    Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling.
    Gastroenterology 137:188-198, 2009
  9. Fukushima J, Kamada Y, Mastumoto H, Yoshida Y, Ezaki H, Takemura T, Saji Y, Igura T, Tsutsui S, Kihara S, Funahashi T, Shimomura I, Tamura S, Kiso S, Hayashi N.
    Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization.
    Hepatol Res 39:724-738, 2009
  10. Kurashige N, Ohkawa K, Hiramatsu N, Yakushijin T, Mochizuki K, Oze T, Kiso S, Kanto T, Takehara T, Kasahara A, Doi Y, Yamada A, Fukuda K, Oshita M, Mita E, Fukui H, Nagase T, Yoshihara H, Imai Y, Kato M, Kashihara T, Hayashi N.
    Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance.
    J Gastroenterol 44:864-700, 2009
  11. Kamada Y, Nakamura T, Funahashi T, Ryo M, Nishizawa H, Okauchi Y, Fukushima J, Yoshida Y, Kiso S, Shimomura I, Hayashi N.
    Visceral obesity and hypoadiponectinemia are significant determinants of hepatic dysfunction: An epidemiologic study of 3827 Japanese subjects.
    J Clin Gastroenterol 43:995-1000,2009
  12. Hikita H, Takehara T, Shimizu S, Kodama T, Li W, Miyagi T, Hosui A, Ishida H, Ohkawa K, Kanto T, Hiramatsu N, Yin XM, Hennighausen L, Tatsumi T, Hayashi N.
    Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver.
    Hepatology 50:1009-1013,2009
  13. Ishii S, Tsuji S, Tsujii M, Nishida T, Watabe K, Iijima H, Takehara T, Kawano S, Hayashi N.
    Restoration of gut motility in Kit-deficient mice by bone marrow transplantation.
    J Gastroenterol 44:834-841, 2009
  14. Nakamoto T, Murayama Y, Oritani K, Boucheix C, Rubinstein E, Nishida M, Katsube F, Watabe K, Kiso S, Tsutsui S, Tamura S, Shinomura Y, Hayashi N.
    A novel therapeutic strategy with anti-CD9 antibody in gastric cancers.
    J Gastroenterol 44:889-896,2009
  15. Shindo M, Chayama K, Mochida S, Toyota J, Tomita E, Kumada H, Yokosuka O, Sata M, Hayashi N, Suzuki K, Okanoue T, Ysubouchi H, Ishikawa H, Seriu T, Omata M.
    Antiviral activity, dose-response relationship, and safety of entecavir following 24-week oral dosing in nucleoside-naive Japanese adult patients with chronic hepatitis B: a randimized, double-blind, phase II clinical trial.
    Hepatol Int 3:445-452, 2009
  16. Kurashige N, Ohkawa K, Hiramatsu N, Oze T, Yakushijin T, Mochizuki K, Hosui A, Miyagi T, Ishida H, Tatsumi T, Kanto T, Takehara T, Hayashi N.
    Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir.
    Antivir Ther 14:873-877, 2009
  17. Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N.
    Anti-cancer chemotherapy inhibits MICA ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma.
    Cancer Res 69:8050-8057, 2009
  18. Hikita H, Takehara T,Kodama T, Shimizu S, Hosui A, Miyagi T, Tatsumi T, Ishida H, Ohkawa K, Li W, Kanto T, Hiramatsu N, Hennighausen L, Yin XM, Hayashi N.
    BH3-only protein Bid participates in the Bcl-2 network in healthy liver cells.
    Hepatology 50:1972-1980, 2009
  19. Uemura A, Takehara T, Miyagi T, Susuki T, Tatsumi T, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N.
    Natural Killer cell is a major producer of interferon γ that is critical for the IL-12-induced anti-tumor effect in mice.
    Cancer Immunol Immunother 59:453-463, 2009