阪大消化器内科のご紹介・研究実績



2020年

原著論文
  1. Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway.
    Murai K, hikita H, Kai Y, Kondo Y, Fukuika M, Fukutomi K, Doi A, Yamai T, Nakabori T, Fukuda R, Takahashi T, Miyakawa K, Suemizu H, Ryo A, Yamada R, Kodama T, Sakamori R, Tatsumi T, Takehara T.
    Sci Rep. 2020 Jan 22;10(1):941.
  2. Prognostic Factors for Patients With a Large Number of Hepatocellular Carcinoma Nodules.
    Abe Y, Ohkawa K, Sakakibara M, Nawa T, Fukutake N, Ikezawa K, Takada R, Kusakabe A, Imai T, Nakanishi K, Tabuchi T, Hikita H, Sakamori R, Tatsumi T, Takehara T, Katayama K.
    J Clin Med Res. 2020 Jan;12(1):26-35.
  3. Concurrent gastric sarcoidosis and early gastric cancer distinguished by magnifying narrow band imaging.
    Kato M, Hayashi Y, Takehara T.
    Dig Endosc. 2020 Mar;32(3):433.
  4. Hepatocellular carcinoma occurrence does not differ between interferon-based and interferon-free treatment with liver histological assessment.
    Tahata Y, Sakamori R, Urabe A, Yamada R, Ohkawa K, Hiramatsu N, Hagiwara H, Oshita M, Hijioka T, Tamura S, Imai Y, Kodama T, Hikita H, Tatsumi T, Takehara T.
    Hepatol Res. 2020 Mar;50(3):313-320.
  5. Hypovascular hepatic nodules as a predictive factor for transcatheter arterial chemoembolization refractoriness in hepatocellular carcinoma.
    Maesaka K, Sakamori R, Yamada R, Tahata Y, Urabe A, Shigekawa M, Kodama T, Hikita H, Tatsumi T, Takehara T.
    Hepatol Res. 2020 Mar;50(3):365-373.
  6. Usefulness of a dedicated mouthpiece for the Valsalva maneuver to visualize the hypopharynx during transoral endoscopy.
    Kato M, Hayashi Y, Uema R, Saiki H, Kimura K, Inoue T, Sakatani A, Yoshii S, Tsujii Y, Shinzaki S, Hida E, Iijima H, Takehara T.
    Endoxc Int Open 2020 Apr;8(4):E536-E543.
  7. Risk Factors for Pancreatic Cancer and the Necessity of Long-term Surveillance in Patients With Pancreatic Cystic Lesions.
    Yoshioka T, Shigekawa M, Ikezawa K, Tamura T, Sato K, Urabe M, Sueyoshi H, Yamai T, Suda T, Sakamori R, Tatsumi T, Takehara T.
    Pancreas. 2020 Apr;49(4):552-560.
  8. Efficacy of vonoprazan for the prevention of bleeding after gastric endoscopic submucosal dissection with continuous use of antiplatelet agents.
    Yoshii S, Yamada T, Yamaguchi S, Hayashi Y, Nakahara M, Shibukawa N, Yamamoto M, Ishihara R, Kinoshita K, Egawa S, Tsujii Y, Iijima H, Takehara T.
    Endosc Int Open. 2020 Apr;8(4):E481-E487.
  9. Psychologic stress and disease activity in patients with inflammatory bowel disease: A multicenter cross-sectional study.
    Araki M, Shinzaki S, Yamada T, Arimitsu S, Komori M, Shibukawa N, Mukai A, Nakajima S, Kinoshita K, Kitamura S, Murayama Y, Ogawa H, Yasunaga Y, Oshita M, Fukui H, Masuda E, Tsujii M, Kawai S, Hiyama S, Inoue T, Tanimukai H, Takehara T.
    PLoS One. 2020 May 26;15(5):e0233365.
  10. Effects of Zinc Acetate on Serum Zinc Concentrations in Chronic Liver Diseases: a Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial and a Dose Adjustment Trial.
    Katayama K, Hosui A, Sakai Y, Itou M, Matsuzaki Y, Takamori Y, Hosho K, Tsuru T, Takikawa Y, Michitaka K, Ogawa E, Miyoshi Y, Ito T, Ida S, Hamada I, Miyoshi K, Kodama H, Takehara T.
    Biol Trace Elem Res. 2020 May;195(1):71-81.
  11. Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study.
    Qi X, Liu Y, Wang J, Fallowfield JA, Wang J, Li X, Shi J, Pan H, Zou S, Zhang H, Chen Z, Li F, Luo Y, Mei M, Liu H, Wang Z, Li J, Yang H, Xiang H, Li X, Liu T, Zheng MH, Liu C, Huang Y, Xu D, Li X, Kang N, He Q, Gu Y, Zhang G, Shao C, Liu D, Zhang L, Li X, Kawada N, Jiang Z, Wang F, Xiong B, Takehara T, Rockey DC; COVID-Cirrhosis-CHESS Group.
    Gut. 2020 May 20:gutjnl-2020-321666.
  12. SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy.
    Yamai T, Hikita H, Fukuoka M, Fukutomi K, Murai K, Nakabori T, Yamada R, Miyakawa K, Watashi K, Ryo A, Kodama T, Sakamori R, Tatsumi T, Takehara T.
    Biochem Biophys Res Commun. 2020 Jun 18;527(1):64-70.
  13. JNJ-4178 (Adafosbuvir, Odalasvir, and Simeprevir) in Japanese Patients With Chronic Hepatitis C Virus Genotype 1 or 2 Infection With or Without Compensated Cirrhosis: The Phase IIa OMEGA-3 Study.
    Takehara T, Chayama K, Kurosaki M, Yatsuhashi H, Tanaka Y, Hiramatsu N, Sakamoto N, Asahina Y, Nozaki A, Nakano T, Hagiwara Y, Shimizu H, Yoshida H, Huang Y, Michael B, Leen V, Hayashi N.
    J Gastroenterol.2020 Jun;55(6):640-652.
  14. Pre-existing Minor Variants With NS5A L31M/V-Y93H Double Substitution Are Closely Linked to Virologic Failure With Asunaprevir Plus Daclatasvir Treatment for Genotype 1b Hepatitis C Virus Infection.
    Morishita N, Sakamori R, Yamada T, Kai Y, Tahata Y, Urabe A, Yamada R, Kodama T, Hikita H, Doi H, Tamura S, Hagiwara H, Imai Y, Iio S, Tatsumi T, Takehara T.
    PLoS One. 2020 Jun 16;15(6):e0234811.
  15. Loss of core fucosylation reduces low-density lipoprotein receptor expression in hepatocytes by inducing PCSK9 production.
    Kamada Y, Yamamoto A, Fujiyoshi A, Koseki M, Morishita K, Asuka T, Takamatsu S, Sakata Y, Takehara T, Taniguchi N, Miyoshi E.
    Biochem Biophys Res Commun. 2020 Jun 30;527(3):682-688.
  16. Serum Mac-2 Binding Protein Levels Associate with Metabolic Parameters and Predict Liver Fibrosis Progression in Subjects with Fatty Liver Disease: A 7-Year Longitudinal Study.
    Kamada Y, Morishita K, Koseki M, Nishida M, Asuka T, Naito Y, Yamada M, Takamatsu S, Sakata Y, Takehara T, Miyoshi E.
    Nutrients. 2020 Jun 12;12(6):1770.
  17. Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score.
    Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Koike T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribasyashi S, Kiyotoki S, Mabe K, Nakamura T, Nakaya N, Fujishiro M, Masamune A.
    　 Gut. 2020 Jun 4:gutjnl-2019-319926.
  18. Endoscopic alterations in Peyer’s patches in patients with ulcerative colitis: A prospective, multicenter study.
    Hiyama S, Iijima H, Sakakibara Y, Yamada T, Mukai A, Otake Y, Yamaguchi T, Araki M, Kawai S, Tsujii Y, Inoue T, Hayashi Y, Shinzaki S, Takehara T.
    J Gastrieterol Hepatol. 2020 Jul;35(7):1143-1149.
  19. Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels.
    Sato K, Hikita H, Myojin Y, Fukumoto K, Murai K, Sakane S, Tamura T, Yamai T, Nozaki Y, Yoshioka T, Kodama T, Shigekawa M, Sakamori R, Tatsumi T, Takehara T.
    PLoS One. 2020 Jul 1;15(7):e0235573.
  20. Clinical course of COVID-19 in patients with pre-existing decompensated cirrhosis: initial report from China.
    Qi X, Wang J, Li X, Wang Z, Liu Y, Yang H, Li X, Shi J, Xiang H, Liu T, Kawada N, Maruyama H, Jiang Z, Wang F, Takehara T, Rockey DC, Sarin SK; COVID-Cirrhosis-CHESS Group.
    Hepatol Int. 2020 Jul;14(4):478-482.
  21. Novel mass spectrometry-based comprehensive lipidomic analysis of plasma from patients with inflammatory bowel disease.
    Iwatani S, Iijima H, Otake Y, Amano T, Tani M, Yoshihara T, Tashiro T, Tsujii Y, Inoue T, Hayashi Y, Takeda K, Hayashi A, Fujita S, Shinzaki S, Takehara T.
    J Gastrienterol Hepatol. 2020 Aug;35(8):1355-1364.
  22. Hepatitis C virus enhances Rubicon expression, leading to autophagy inhibition and intracellular innate immune activation.
    Shiode Y, Hikita H, Tanaka S, Shirai K, Doi A, Sakane S, Kai Y, Nakabori T, Yamada R, Kodama T, Narumi R, Sakamori R, Eguchi H, Tomonaga T, Tatsumi T, Takehara T.
    Sci Rep. 2020 Sep 17;10(1);15290.
  23. Detection of Phosphorylated Alpha-Synuclein in the Muscularis Propria of the Gastrointestinal Tract Is a Sensitive Predictor for Parkinson's Disease.
    Beck G, Hori Y, Hayashi Y, Morii E, Takehara T, Mochizuki H.
    Parkinsons Dis. 2020 Sep 23;2020:4687530.
  24. Oligosaccharide-dependent anti-inflammatory role of galectin-1 for macrophages in ulcerative colitis.
    Iwatani S, Shinzaki S, Amano T, Otake Y, Tani M, Yoshihara T, Tsujii Y, Hayashi Y, Inoue T, Okuzaki D, Mizushima T, Miyoshi E, Iijima H, Takehara T.
    J Gastroenterol Hepatol. (in press)
  25. Lower serum sodium levels are associated with the therapeutic effect of sorafenib on hepatocellular carcinoma.
    Kegasawa T, Sakammori R, Maesaka K, Yamada R, Tahata Y, Urabe A, Kodama T, Hikita H, Imanaka K, Ohkawa K, Hiramatsu N, Oshita M, Yamada Y, Inada M, Yakushijin T, Imai Y, Tatsumi T, Takehara T.
    Dig Dis Sci. (in press)
  26. Prophylactic clipping not effective in preventing post-polypectomy bleeding for < 20-mm colon polyps: A multicenter, open-label, randomized controlled trial.
    Inoue T, Ishihara R, Nishida T, Akasaka T, Hayashi Y, Nakamatsu D, Ogiyama H, Yamaguchi S, Yamamoto K, Mukai A, Kinoshita K, Yakushijin T, Iijima H, Takehara T.
    J Gastroenterol Hepatol. (in press)
  27. Therapeutic efficacy of lenvatinib in hepatocellular carcinoma patients with portal hypertension.
    Maesaka K, Sakamori R, Yamada R, Urabe A, Tahata Y, Oshita M, Ohkawa K, Mita E, Hagiwara H, Tamura S, Ito T, Yakushijin T, Iio S, Kodama T, Hikita H, Tatsumi T, Takehara T.
    Hepatpl Res. (in press)
  28. Clinical outcomes of direct-acting antiviral treatments for hepatitis C patients after hepatocellular carcinoma are equivalent to interferon treatment.
    Tahata Y, Sakamori R, Urabe A, Yamada R, Ohkawa K, Hiramatsu N, Hagiwara H, Oshita M, Imai Y, Kodama T, Hikita H, Tatsumi T, Takehara T.
    Hepatol Res. (in press)
  29. Initial treatment response to transarterial chemoembolization as a predictive factor for Child-Pugh class deterioration prior to refractoriness in hepatocellular carcinoma.
    Maesaka K, Sakamori R, Yamada R, Tahata Y, Imai Y, Oshita M, Ohkawa K, Kodama T, Hikita H, Tatsumi T, Takehara T.
    Hepatol Res. (in press)
  30. Improvement of Skeletal Muscle Mass after Ledipasvir and Sofosbuvir Treatment for Hepatitis C Virus in Decompensated Liver Cirrhosis: A Case Report.
    Sakamori R, Yamada R, Shinkai K, Doi A, Tahata Y, Shigekawa M, Kodaa T, Hikita H, Yamada T, Tatsumi T, Takehara T.
    Intern Med. (in press)
  31. Endoscopic biliary stenting as the risk factor for cholangitis after endoscopic ultrasound in patients with biliary strictures.
    Ikezawa K, Shigekawa M, Yamai T, Suda T, Kegasawa T, Yoshioka T, Sakamori R, Tatsumi T, Takehara T.
    J Gastroenterol Hepatol. (in press)
  32. Sofosbuvir plus velpatasvir treatment for hepatitis C virus in patients with decompensated cirrhosis: A Japanese real-world multicenter study.
    Tahata Y, Hikita H, Mochida S, Kawada N, Enomoto N, Ido A, Yoshiji H, Miki D, Hiasa Y, Takikawa Y, Sakamori R, Kurosaki M, Yatsuhashi H, Tateishi R, Ueno Y, Itoh Y, Yamashita T, Kanto T, Suda G, Nakamoto Y, Kato N, Asahina Y, Matsuura K, Terai S, Nakao K, Shimizu M, Takami T, Akuta N, Yamada R, Kodama T, Tatsumi T, Yamada T, Takehara T.
    J Gastroenterol. (in press)
  33. "Floating" method and "lifting up" method: novel techniques of gastric　endoscopic submucosal dissection for treating difficult-to-approach lesions.
    Yoshii S, Hayashi Y, Uema R, Tsujii Y, Iijima H, Takehara T.
    Endoscopy. (in press)

邦論文

  1. HBV/HCV共感染患者に対するDAA治療後のHBV再活性化
    　　村井一裕, 疋田隼人, 竹原徹郎
    　　肝臓 2020 61巻5号240-241.