RESULTS

Methylosystem for Cancer Sieging Strategy(Cancers 2021)

In the international collaboration with Department of Radiation Oncology, Osaka University Graduate School of Medicine, Japan (Professor Ogawa) and Italy (Professor Vecchione), Dr. Tatekawa proposed the therapeutic concept, “methylosystem” (i.e., the intercellular and intracellular communications of upstream regulatory factors and/or downstream effectors that affect the epigenetic mechanism involving the transfer of a methyl group from S-adenosylmethionine (SAM) onto the specific positions of nucleotides or other metabolites in the tumor microenvironment) and emphasized the importance of tracking these metabolic products for understanding spatial heterogeneity. Their significance and implications will contribute to the discovery of efficient methods for the diagnosis of and therapeutic approaches to human cancer.