RESULTS

Metabolic adaptation to nutritional stress in human colorectal cancer ( Scientific Reports, 2016 )
In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Miyo and Konno et al.
demonstrated that colorectal cancer cells survived under the condition of glucose depletion, and their resistance to such conditions depended on genomic alterations rather than on KRAS mutation alone. Metabolomic analysis demonstrated that those cells maintained tricarboxylic acid cycle activity and ATP production under such conditions. The study showed that pivotal roles of GLUD1 and SLC25A13 in nutritional stress. Thus GLUD1 and SLC25A13 may serve as new targets in treating refractory colorectal cancer which survive in malnutritional microenvironments.