RESULTS

The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Int J Oncol, 2017)
In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Konno et al.
demonstrated the importance of one-carbon metabolism pathway in drug discovery. In this review, they focused on the understanding of the one-carbon metabolism pathway to unravel the link between the causes and effects of cancer phenotypes. The characterization of one-carbon metabolism is indispensable to the development of precision medicine in the context of cancer diagnostics and therapeutics. They review the historical issues associated with one-carbon metabolism and highlight the recent advances in cancer research.