RESULTS

Insulinoma medium induces the differentiation of mesenchymal cells into insulin-producing β-like cells (J Stem Cell Res Ther, 4, 1000221, 2014)

In the collaboration of the Research Institute, National Center for Global Health and Medicine, Kawamoto et al. demonstrated that m urine insulinoma cell conditioned medium with ΒETA2 (NeuroD1) transduction efficiently induces the differentiation of adipose-derived mesenchymal stem cells (ADSC) into insulin-producing β-like cells both in vitro and in vivo. ΒETA2 is a member of the basic helix-loop-helix transcription factor family. These results suggest that the balance of the cytokines and growth factors in addition of gene manipulation would be beneficial for efficient differentiation of ADSCs into pancreatic β cells. Our technology could provide a path to β cell differentiation and novel cell replacement-based therapies for diabetes.