RESULTS

Identification of chemoradiation-resistant osteosarcoma stem cells using an imaging system (Int J Oncol, 45, 2349, 2014)

In the collaboration with the Department of Radiation Oncology, Osaka University, Tamari, et al. identified a subpopulation of cells with stem cell-like characteristics, such as tumor-initiating cells (TICs), which maintain the capacity to regenerate entire tumors. The study separated the osteosarcoma cells using the fluorescence-activated cell sorting (FACS)-based system and verified TIC-like properties. The present study demonstrated that chemoradiation-resistant cancer stem cells can be visualized by this system and suggested the rationale for further study of osteosarcoma stem cells.