RESULTS

The importance of one carbon (C1) metabolism: mitochondrial folate enzymes in human colorectal cancer ( Oncology Reports, 2016)

In collaboration with the Department of Surgery, Osaka University (Profs. Masaki Mori and Yuichiro Doki), Miyo et al. demonstrate that the importance of mitochondrial folate enzymes of one carbon (C1) metabolism in human colorectal cancer. The data indicate that three mitochondrial folate metabolic enzymes, serine hydroxymethyl transferase (SHMT2), methylenetetrahydrofolate dehydrogenase (MTHFD2), and aldehyde dehydrogenase 1 family member L2 (ALDH1L2), play a role in human colorectal tumor tissues. The present study demonstrates that C1 metabolic enzymes could provide a potential therapeutic strategy for treating colorectal cancer.