• Targeting cancer stem cells in refractory cancer (Regenerative Therapy, 2021, in press)

    In collaboration with Osaka University, Osaka International Cancer Institute, and Kyushu University, Dr. Miyoshi et al. updated that the innovative approaches for cancer stem cells, but also for immune cells and other mesenchymal cells. This novel approach in diagnosis and therapy will open an avenue to cancer precision medicine.

  • A four-dimensional organoid system to visualize cancer cell vascular invasion (Biology, 2020, in press)
    In collaboration with Osaka University Graduate School of Medicine, Department of Gastroenterology (Profs Yuichiro Doki, Hidetoshi Eguchi, Masaki Mori) and Graduate School of Engineering, Department of Applied Chemistry (Prof Michiya Matsusaki), Yanagisawa et al. studied a four-dimensional (4D) organoid system to visualize cancer cell vascular invasion. Using this model, it was possible to observe and evaluate the cell dynamics and histological positional relationship of invasive cancer cells in four dimensions. Thus, drug discovery using this vascular invasion mimic model will be advanced and many applications are expected. 
  • immuno-surgical management of pancreatic cancer with analysis of cancer exosomes (Cells, 2020, in press).   
    In the international collaboration with Hirotsu Bio Science Inc., Kinshu-kai Medical Corporation, IDEA Consultants Inc., Kyowa-kai Medical Corporation, Unitech Co. Ltd., as well as department of gastroenterology (Profs Yuichiro Doki and Hidetoshi Eguchi), Takeda et al. updated the state-of-art technology of immuno-surgical strategy of monitoring pancreatic cancer for its early diagnosis and therapy.
  • Application of C. elegans to cancer screening test (Book Chapter, Prime Archives in Cancer Research)
    In collaboration with Hirotsu Bio Science Inc. as well as department of gastroenterology (Profs Yuichiro Doki and Hidetoshi Eguchi), the industry-academia collaborative research updated the application of C. elegans to cancer precision medicine.
  • State-of-the-Art Technology of Model Organisms for Current Human (Diagnostics, 2020, in press)
    In the international collaboration with Hirotsu Bio Science Inc., Kinshu-kai Medical Corporation, IDEA Consultants Inc., Kyowa-kai Medical Corporation, Unitech Co. Ltd., as well as department of gastroenterology (Profs Yuichiro Doki and Hidetoshi Eguchi), Konno et al. reviewerd the state-of-art technology for the diagnosis of human diseases by utilizing various organisms as tools. 
  • Genome-wide association meta-analysis identifies risk variants for pancreatic cancer (Nature Communications, 2020, in press)
    In inter-institutional collaboration with the Aichi Cancer Center (Professor Keitaro Matsuo), the genome characteristics in pancreatic cancer were studied and elucidated for further improvement of precision medicine in Japan.

  • Convolutional neural network can recognize drug resistance of single cancer cells (Int. J. Mol. Sci., 2020, in press).   

    In the international collaboration with University of Rome, as well as department of gastroenterology (Profs Yuichiro Doki and Hidetoshi Eguchi), Yanagisawa et al. performed the analysis of drug resistance of single cancer cells by the convolutional neural network (CNN) model, which demonstrated that a CNN based on the VGG16 model could predict the efficiency of anti-tumor drugs at single-cell level, suggesting that precision medicine for individual patients may be possible by extracting circulating tumor cells from blood by using an AI system.

  • COVID-19 drug discovery using intensive approaches (Int. J. Mol. Sci., 2020, in press).   

    In the international collaboration with Hirotsu Bio Science Inc., Kinshu-kai Medical Corporation, IDEA Consultants Inc., Kyowa-kai Medical Corporation, Unitech Co. Ltd., as well as department of gastroenterology (Profs Yuichiro Doki and Hidetoshi Eguchi), Asai et al. reviewerd the state-of-art technology for the drug repositioning discovery against COVID-19. 
  • Hereditary pancreatitis model by blastocyst complementation in mouse (Oncotarget, 2020, in press).
    In the international collaboration with Unitech Co., Ltd., Asai et al. established the mouse model by the blastocyst complementation (BC) method, which mimics to human hereditary pancreatitis, and showed that the BC method was useful for the reproduction and study of pancreatic disorders. The present study opens the possibility of investigating uncharacterized human diseases by utilizing the BC method.

  • Theoretical analyses and experimental validation of effects caused by fluorinated substituent modification of DNA (Scientific Reports, 2020, in press)

    In collaboration with Osaka University Graduate School of Medicine, Department of Gastroenterology (Profs Yuichiro Doki and Masaki Mori) and Graduate School of Pharmaceutical Sciences (Prof Obika), as well as Taiho Pharmaceutical Co., Ltd, Koseki et al. performed the structural based studies of nucleotide medicine. Given that halogen-modified nucleic acid molecules, such as trifluorothymidine (FTD) and 5-fluorouracil, are widely used in medical science and clinical site, our study focused on the reason why a large differences between FTD and 5-fluorouracil occurs. The results showed the important structural changes caused by trifluoromethyl group, for the anti-tumor effect of FTD.