2016年 ［ 2016年｜2015年｜2014年｜2013年｜2012年｜2011年｜2010年以前｜（2017年以降→） ］

Hayano, Y., Takasu, K., Koyama, Y., Ogawa, K., Minami, K., Asaki, T., Kitada, K., Kuwabara, S. and Yamashita, T. (2016) Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B. J. Exp. Med.213, 2949-2966. 神経障害性疼痛のメカニズムを解明し、分子標的治療法の開発に繋がる成果を得ました。 http://jem.rupress.org/content/early/2016/11/16/jem.20160877 医学系研究科の主要研究成果 http://www.med.osaka-u.ac.jp/jpn/activities/results/2016/016.html Itami, C., Huang, J.Y., Yamasaki, M., Watanabe, M., Lu, H.C. and Kimura, F. (2016) Developmental switch in spike timing-dependent plasticity and cannabinoid -dependent reorganization of the thalamocortical projection in the barrel cortex. J. Neurosci. 36, 7039-7054 Fujiwara, K., Fujita, Y., Kasai, A., Onaka, Y., Hashimoto, H., Okada, H. and Yamashita, T. (2016) Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior, and memory deficits in mouse. Transl. Psychiatry 6, e766. Ozaki, T., Muramatsu, R., Sasai, M., Yamamoto, M., Kubota, Y., Fujinaka, T., Yoshimine, T. and Yamashita, T. (2016) The P2X4 receptor is required for neuroprotection via ischemic preconditioning. Scientific Reports 6, 25893 Harada, K., Fujita, Y. and Yamashita, T. (2016) Repulsive guidance molecule A suppresses angiogenesis. Biochem. Biophys. Res. Commun. 469, 993-999. Hamasaki, H., Fujitani, M. and Yamashita, T. (2016) NME2 associates with PTPs to transduce signals from chondroitin sulfate proteoglycans. Biochem. Biophys. Res. Commun.471, 522-527. Kuroda, M., Muramatsu, R., and Yamashita, T. (2016) Cardiomyocyte-released factors stimulate oligodendrocyte precursor cells proliferation.Biochem. Biophys. Res. Commun. 482, 1160-1164. Jin, X. and Yamashita, T. Microglia in central nervous system repair after injury. J. Biochem.159, 491-496. 山下俊英: 脊髄損傷後のリハビリテーション効果のメカニズム、Clinical Neuroscience、34:,242-243, 2016 鈴木一博、山下俊英、熊ノ郷淳: 見えてきた！？　神経・免疫クロストーク、最新医学、最新医学社、71: 161-170, 2016 山下俊英: 神経炎症と神経再生を制御するRGMの機能、最新医学、最新医学社、 71: 188-193, 2016 山下俊英: 軸索再生とRhoシグナル、Clinical Neuroscience、10: 1109-1112, 2016 山下俊英: 神経疾患と慢性炎症、最新医学、71:, 2309-2313,2016

2015年 ［ 2016年｜2015年｜2014年｜2013年｜2012年｜2011年｜2010年以前｜（2017年以降→） ］

van Erp, S., van den Heuvel, D.M.A., Fujita, Y., Robinson, R.A., Hellemons, A.J., Adolfs, Y., Van Battum, E.Y., Blokhuis, A.M., Kuijpers, M., Demmers, J., Hedman, H., Hoogenraad, C.C., Siebold, C., Yamashita, T. and Pasterkamp, R.J. (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev. Cell 35, 537-552. Arima, Y., Kamimura, D., Atsumi, T., Harada, M., Kawamoto, T., Nishikawa, N., Stofkova, A., Ohki, T., Higuchi, K., Morimoto, Y., Wieghofer, P., Okada, Y., Mori, Y., Sakoda, S., Saika, S., Yoshioka, Y., Komuro, I., Yamashita, T., Hirano, T., Prinz, M., Murakami, M. (2015) Pain-mediated sympathetic activation induces relapse via microglia accumulation in a multiple sclerosis model. eLIFE 4, e08733. Miyake, S., Muramatsu, R., Hamaguchi, M. and Yamashita, T. (2015) Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury. Cell Death Dis. 6, e1638 Muramatsu, R., Kuroda, M., Matoba, K., Hsiaoyun, L., Takahashi, C., Koyama, Y., Yamashita, T. (2015) Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system. J. Biol. Chem. 290, 11515-25.. Nakagawa, H., Ninomiya, T., Yamashita, T. and Takada, M. (2015) Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques. Sci. Rep. 5, 11986. Fujita, Y., Fujiwara, K., Zenitani, S. and Yamashita, T. (2015) Acetylation of NDPK-D regulates its subcellular localization and cell survival. PLoS ONE 10, e0139616. Toda, T., Ishida, K., Kiyama, H. Yamashita, T. and Lee, S. (2015) Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity. PLoS ONE 9, e114328. Hirano, M., Satake, W., Ihara, K., Tsuge, I., Kondo, S., Betsui, H., Okubo, K., Sakamoto, H., Ueno, S., Ikuno, Y., Ishihara, R., Iwahashi, H., Ohishi, M., Mano, T., Yamashita, T., Suzuki, Y., Nakamura, Y., Kusunoki, S. and Toda, T. (2015) The first nationwide survey and genetic analyses of Bardet-Biedl syndrome. PLoS ONE 10, e0136317. Yamashita, T. (2014) Significance of corticospinal tract sprouting after cortical injury in rodents. J. Neurosci. Neuroeng. In press. Sumimoto, S., Muramatsu, R., Yamashita, T. (2015) Thromboxane A2 stimulates neurite outgrowth in cerebral cortical neurons via mitogen activated protein kinase signaling. Brain Res. 1594, 46-51. Fujita, Y. and Yamashita, T. (2014) Microglia, Neuroprotection and Regeneration for Retinal Diseases, Neuroprotection and Neuroregeneration for retinal diseases, Springer, p175-187. 山下俊英: 神経炎症と神経・免疫クロストーク—神経炎症と神経再生をつなぐ分子—、感染・炎症・免疫、羊土社、44: , 2015 山下俊英: ROCKと神経再生、Medical View Point、興和創薬株式会社、36 (2), 2015 山下俊英: 軸索再生阻害因子を標的とした中枢神経回路の再生と細胞保護、神経眼科、日本神経眼科学会、32: 255-262, 2015 山下俊英: 網膜の炎症とミクログリア、Clinical Neuroscience、33:, 2015

2014年 ［ 2016年｜2015年｜2014年｜2013年｜2012年｜2011年｜2010年以前｜（2017年以降→） ］

Tanabe, S. and Yamashita, T. (2014) Repulsive guidance molecule-a is involved in Th17-cell-induced neurodegeneration in autoimmune encephalomyelitis. Cell Rep. 9, 1459-1470. 多発性硬化症の病態下で、ヘルパーT細胞がニューロンを傷つけるメカニズムを明らかにしました。 http://www.cell.com/cell-reports/abstract/S2211-1247(14)00907-3 JSTからのプレスリリース http://www.jst.go.jp/pr/announce/20141114/index.html Ueno, M., Fujiki, R. and Yamashita, T. (2014) A selector orchestrates cortical function. Nat. Neurosci. 17, 1016-1017. Hayano, Y., Sasaki, K., Ohmura, N., Takemoto, M., Maeda, Y., Yamashita, T., Hata, Y., Kitada, K and Yamamoto, N. (2014) Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion.Proc. Natl. Acad. Sci. USA 111, 15226-15231. Ueno, M. and Yamashita, T. (2014) Bidirectional tuning of microglia in the developing brain: From neurogenesis to neural circuit formation. Curr. Opin. Neurobiol 27C, 8-15. Lee, S., Toda, T., Kiyama, H. and Yamashita, T. (2014) Weakened rate-dependent depression of Hoffmann’s reflex and increased motoneuron hyperactivity after motor cortical infarction in mice. Cell Death Dis. 5, e1007. Zhang, S., Kanemitsu, Y., Fujitani, M. and Yamashita, T. (2014) The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex. Sci. Rep 4, 5984. Suehiro, K., Nakamura, Y., Xu, S., Uda, Y., Matsumura, T., Yamaguchi, Y., Okamura, H.Yamashita, T. and Takei, Y. (2014) Ecto-domain phosphorylation promotes functional recovery from spinal cord injury. Sci. Rep. 4, 4972. Itokazu, T., Hayano, Y., Takahashi, R. and Yamashita, T. (2014) Involvement of Wnt/β-catenin signaling in the development of neuropathic pain. Neurosci. Res 79, 34-40. Sumimoto, S., Muramatsu, R., Fujii, S., Yamashita, T. (2014) Vascular endothelial cells promote cortical neurite outgrowth via an integrin beta3-dependent mechanism. Biochem. Biophys. Res. Commun 450, 593-597. Fujita, Y. and Yamashita, T. (2014) Role of DAPK in neuronal cell death. Apoptosis 19, 339-345. Fujita, Y. and Yamashita, T. (2014) Microglia, Neuroprotection and Regeneration for Retinal Diseases, Springer. Ueno, M. and Yamashita, T. (2014) The brain-immune network in spinal cord injury, Springer. Fujita, Y and Yamashita, T. (2014) Axon growth inhibition by Rho/ROCK. Front. Neurosci. Muramatsu, R. and Yamashita, T. (2014) Concept and molecular basis of axonal regeneration after central nervous system injury. Neurosci Res. 78, 45-49. Muramatsu, R. and Yamashita, T. (2014) Pericyte function in the physiological central nervous system. Neurosci Res. 81-82, 38-41. Kimura, Y., Fujita, Y. and Yamashita, T. (2014) Effect of the Sigma-1 receptor on neurite outgrowth. Receptors & Clinical Investigation 1, 8-12. Fujita, Y and Yamashita, T. (2014) The functions and signaling pathways induced by the interactions of APP–related molecules with p75NTR. Receptors & Clinical Investigation 1, 299-303. 村松里衣子、山下俊英: 中枢神経炎症からの再生メカニズム、Annual Review神経　2014、中外医学社、221-225, 2014 山下俊英: 中枢神経回路の修復現象とそのメカニズム、脳神経系の発生・再生の融合的新展開、診断と治療社、2014 山下俊英: 網膜における慢性炎症、脳２１、金芳堂、17: 2014

2013年 ［ 2016年｜2015年｜2014年｜2013年｜2012年｜2011年｜2010年以前｜（2017年以降→） ］

Ueno, M., Fujita, Y., Tanaka, T., Nakamura, Y., Kikuta, J., Ishii, M. and Yamashita, T. (2013) Layer V cortical neurons require microglial support for survival during postnatal development. Nat. Neurosci. 16, 543-551. 脳の免疫細胞が運動の神経細胞を保護することを発見しました。ＡＬＳなど運動機能障害性の脳神経疾患への新たな治療法の開発に繋がる成果です。 大阪大学ホームページ http://www.med.osaka-u.ac.jp/jpn/activities/results/2013/002.html JST/大阪大学からのプレスリリース http://www.jst.go.jp/pr/announce/20130325/index.html ライフサイエンス新着論文レビュー http://first.lifesciencedb.jp/archives/6794 Fujiki, R., Sato, A., Fujitani, M. and Yamashita, T. (2013) A proapoptotic effect of valproic acid on progenitors of embryonic stem cell-derived glutamatergic neurons. Cell Death Dis. 4, e677. Nakagawa, H., Ueno, M., Itokazu, T. and Yamashita, T. (2013) Bilateral movement training promotes axonal remodeling of the corticospinal tract and recovery of motor function following traumatic brain injury in mice. Cell Death Dis. 4, e534. Uesugi, N., Kimura, Y. and Yamashita, T. (2013) Suppression of the p75 receptor signal attenuates the effect of ephrin-B3 and promotes axonal regeneration of the injured optic nerve. Cell Death Dis. 4, e557. Tanaka, T., Fujita, Y., Ueno, M., Shultz, L.D. and Yamashita, T. (2013) Suppression of SHP-1 promotes functional corticospinal tract rewiring after brain injury. Cell Death Dis. 4. e567. Onishi, M., Fujita, Y., Yoshikawa, H. and Yamashita, T. (2013) Inhibition of Rac1 promotes BMP-2–induced osteoblastic differentiation. Cell Death Dis. 4, e698. Ishii, H., Tanabe, S., Ueno, M., Kubo, T., Kayama, H., Serada, S., Fujimoto, M., Takeda, K., Naka, T. and Yamashita, T. (2013) ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis. 4, e710. Fujita, Y., Sato, A. and Yamashita, T. (2013) Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation. Cell Death Dis. 4. E763. Takahashi, C., Muramatsu, R., Fujimura, H., Mochizuki, H. and Yamashita, T. (2013) Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination. Cell Death Dis. 4, e795. Kimura, Y., Fujita, Y., Shibata, K., Mori, M. and Yamashita, T. (2013) Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling. PLoS ONE 8, e75760. Hasebe, N., Fujita, Y., Ueno, M., Yoshimura, K., Fujino, Y. and Yamashita, T. (2013) Soluble β-amyloid precursor protein alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PLoS ONE Fujiki, R., Sato, A., Hata, K., Tashiro, F., Yasuhara, Y., Miyazaki, J., Yoneda, Y., Fujitani, M. and Yamashita, T. (2013) Improvement in protocol to generate homogeneous glutamatergic neurons from mouse embryonic stem cells reduced apoptosis. Biochem. Biophys. Res. Commun. 430, 604-609. Shibata, K., Nakahara, S., Shimizu, E., Yamashita, T., Matsuki, N. and Koyama, R. (2013) Repulsive guidance molecule a (RGMa) regulates axonal morphogenesis in the hypocampus. NeuroReport 24, 609-615. 糸数隆秀、高橋良輔、山下俊英: 錐体路の機能回復メカニズム、Annual Review神経　2013、中外医学社、22-28, 2013 村松里衣子、山下俊英：中枢神経傷害後の皮質脊髄路の再編成と機能回復のメカニズ ム、脳２１、16: 42-45, 2013 山下俊英: 脳脊髄損傷後の運動機能回復のメカニズム解明に向けて、脳２１、金芳堂、16: 7-11, 2013 上野将紀、藤田幸、山下俊英: 脳発達期においてミクログリアは大脳皮質第５層神経細胞の生存に寄与する、ライフサイエンス 新着論文レビュー、2013 村松里衣子、山下俊英: 病態モデルと神経−血管相互作用、血管医学、メディカルレ ビュー社、2013 村松里衣子: 新生血管による神経回路修復機構の解明、神経化学、52: 45-47, 2013 山下俊英: 網膜における慢性炎症、脳２１、金芳堂、17: 2014

2012年 ［ 2016年｜2015年｜2014年｜2013年｜2012年｜2011年｜2010年以前｜（2017年以降→） ］

Muramatsu, R., Takahashi, C., Miyake, S., Fujimura, H., Mochizuki, H. and Yamashita, T. (2012) Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin. Nature Medicine 18, 1658-1664. 傷害された中枢神経回路が自然に修復するメカニズムを発見しました。 JST/大阪大学よりプレスリリース http://www.jst.go.jp/pr/announce/20121008/index.html Ueno, M., Hayano, Y., Nakagawa, H. and Yamashita, T. (2012) Intraspinal rewiring of the corticospinal tract requires target-derived BDNF and compensates lost function after brain injury. Brain 135, 1253-1267. 詳しい内容はこちら Tanokashira, D., Morita,T., Hayashi, K., Mayanagi, T., Fukumoto, K., Kubota, Y., Yamashita, T. and Sobue, K. (2012) Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression. J. Neurosci. 32, 14583-14560. Ishii, H., Jin, X., Ueno, M., Tanabe, S., Kubo, T., Serada, S., Naka, T. and Yamashita, T. (2012) Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury. Cell Death Dis. 3, e363. Kurihara, D. and Yamashita, T. (2012) Chondroitin sulfate proteoglycans downregulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB). J. Biol. Chem. 287, 13822-13828. Itokazu, T., Fujita, Y., Takahashi, R. and Yamashita, T. (2012) Identification of the neogenin-binding site on the repulsive guidance molecule a.  PLoS One 7, e32791. Jin, X., Ishii, H., Bai, Z., Itokazu, T. and Yamashita, T. (2012) Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice. PLoS ONE 7, e41892. Kubo, T., Tokita, S. and Yamashita, T. (2012) Repulsive guidance molecule-a and demyelination: Implications for multiple sclerosis. J. Neuroimmune Pharmacol. 7, 524-528. 山下俊英: Repulsive guidance molecule (RGM)ー自己免疫性脊髄炎・多発性硬化症の新たな治療標的、リウマチ科、科学評論社、47: 389-395, 2012 糸数隆秀、高橋良輔、山下俊英: 多発性硬化症−新規薬剤とその分子標的、分子標的薬—がんから他疾患までの治癒をめざして、日本臨床、日本臨床社、609-612、2012 村松里衣子、山下俊英: 多発性硬化症への新規治療戦略、ファルマシア、48： 935-939, 2012 山下俊英、藤田幸: 視覚が戻る−傷ついた視神経が再生する、未来材料、株式会社エヌ・ティー・エス、12 (8): 38-41, 2012 村松里衣子、山下俊英：中枢神経回路の障害と修復を制御する生体システム、脳２１ 村松里衣子、山下俊英：新生した血管から放出されるプロスタサイクリンは神経回路の再生を促進する、ライフサイエンス 新着論文レビュー、2012

2011年 ［ 2016年｜2015年｜2014年｜2013年｜2012年｜2011年｜2010年以前｜（2017年以降→） ］

Muramatsu, R., Kubo, T., Mori, M., Nakamura, Y., Fujita, Y., Akutsu, T., Okuno, T., Taniguchi, J., Kumanogoh, A., Yoshida, M., Mochizuki, H., Kuwabara, S. and Yamashita, T. (2011) RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nature Medicine 17, 488-494. RGMaがT細胞の活性化を制御すること、またRGMa中和抗体が自己免疫性脳脊髄炎の発症および再発を抑制することを報告しました。多発性硬化症の治療開発に繋がる成果です。 大阪大学よりプレスリリース 詳しい内容はこちら 久保武一氏のこと Sanuki, R., Onishi, A., Koike, C., Muramatsu, R., Watanabe, S., Muranishi, Y, Irie, S., Ueno, S., Koyasu, T., Matsui, R., Cherasse, Y., Urade, Y., Watanabe, D., Kondo, M., Yamashita, T. and Furukawa, T. (2011)miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nature Neurosci. Fujita, Y., Endo, S., Takai, T. and Yamashita, T. (2011) Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J. 30, 1389-1401. 傷ついた視神経の再生を抑制するメカニズムを明らかにするとともに、マウスを用いた実験で視神経を再生させることに成功しました。 JST／大阪大学よりプレスリリース http://www.jst.go.jp/pr/announce/20110302/index.html Yamagishi, S., Hampe1, F., Hata, K., del Toro, D., Schwark, M., Kvachnina, E., Bastmeyer, M., Yamashita, T., Tarabykin, V., Klein, R. and Egea. J. (2011) FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J. 30, 2920-2933. Lee, S., Ueno, M. and Yamashita, T. (2011) Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of γ-aminobutyric acid signaling. Cell Death Dis. 2, e133. Ohara, R., Fujita, Y., Hata, K., Nakagawa, M. and Yamashita, T. Axotomy induces axonogenesis in hippocampal neurons through STAT3. Cell Death Dis. 2, e175. Fujita, Y., Takashima, R. Endo, S., Takai, T. and Yamashita, T. The p75 receptor mediates axon growth inhibition through an association with PIR-B. Cell Death Dis. 2, e198. Imagama, S., Sakamoto, K., Tauchi, R., Shinjo, R., Ohgomori, T., Ito, Z., Zhang, H., Nishida, Y., Asami, N., Takeshita, S., Sugiura, N., Watanabe, H., Yamashita, T., Ishiguro, N., Matsuyama, Y. and Kadomatsu K. (2011) Keratan sulfate restricts neural plasticity after spinal cord injury. J. Neurosci. 31, 17091-17102. Nakamura, Y., Fujita, Y., Ueno, M., Takai, T. and Yamashita, T. (2011) Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury. J. Biol. Chem. 286, 1876-1883. Nogoの受容体であるPirBおよびNogo受容体を抑制しても脊髄損傷後の機能的再生が認められないことを報告しました。 Hagihara, M., Endo, M., Hata, K., Higuchi, C., Takaoka, K., Yoshikawa, H. and Yamashita, T. (2011) Neogenin: A receptor for bone morphogenetic proteins. J. Biol. Chem. 286, 5157-5165. NeogeninがBMPのシグナルを伝えることを報告しました。 Science SignalingのEditors’ Choiceで紹介されました。 Neogenin, a "Neo" Receptor for BMP http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/161/ec54 Ueno, M. and Yamashita, T. (2011) Kinematic analyses reveal impaired locomotion following injury of the motor cortex in mice. Exp. Neurol. 230, 280-290. Kitayama, M., Ueno, M., Itakura, T. and Yamashita, T. (2011) Activated microglia inhibit axonal growth through RGMa. PLoS One 6, e25234. Ohara, R., Hata, K., Yasuhara, N., Mehmood, R., Yoneda, Y., Nakagawa, M. and Yamashita, T. (2011) Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on Importin β. Biochem. Biophys. Res. Commun. 405, 697-702. Omoto, S., Ueno, M., Mochio, S. and Yamashita, T. (2011) Corticospinal tract fibers cross the ephrin-B3–negative part of the midline of the spinal cord after brain injury. Neurosci. Res. 69, 187-195. Okamura, Y., Kohmura, E. and Yamashita, T. (2011) TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule. Neurosci. Res. 71, 63-70. Yoshimura, K., Ueno, M., Lee, S., Nakamura, Y., Sato, A., Yoshimura, K., Kishima, H., Yoshimine, T. and Yamashita, T. (2011) C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice. Neurosci. Res. 71, 266-277. Ryu, M., Nakazawa, T., Akagi, T., Tanaka, T., Watanabe, R., Yasuda, M., Himori, N, Maruyama, K., Yamashita, T., Abe, T., Akaishi, M. and Nishida, K. (2011) Suppression of phagocytic cells in retinal disorders using amphiphilic poly (γ-glutamic acid) nanoparticles containing dexamethasone. J. Control. Release 151, 65-73. Hirano, M., Ohishi, M., Yamashita, T., Ikuno, Y., Iwahashi, H., Mano, T., Ishihara, R., Tanaka, I., Yanagihara, K., Isono, C, Sakamoto, H, Nakamura, Y, Kusunoki, S. (2011) Abnormal cystatin C levels in two patients with Bardet-Biedl syndrome. Clin. Med. Insights Case Rep. 4, 17-20. Fang, X., Ueno, M., Yamashita, T. and Ikuno, Y. (2011) RhoA activation and effect of Rho-kinase inhibitor in the development of retinal neovascularization in a mouse model of oxygen-induced retinopathy. Curr. Eye Res. 36, 1028-1036. Kubo, T., Tokita, S. and Yamashita, T. (2011) Crosstalk between the immune and central nervous systems with special reference to drug development. Drug Development - A Case Study Based Insight into Modern Strategies, Intec Publishers, p365-380. 山下俊英: 中枢神経の軸索再生を制御する分子機構、脳２１、2011 村松里衣子、山下俊英: RGMはT細胞活性化を制御し、自己免疫性脳脊髄炎に関与する、ライフサイエンス 新着論文レビュー、2011 山下俊英: 失われた神経回路を取り戻すために、共創・協奏（独立行政法人　科学技術振興機構　JSTイノベーションプラザ大阪　編）、55-68, 2011 山下俊英: 中枢神経障害による神経症状を改善する治療薬の開発の現状と今後、医薬品医療機器レギュラトリーサイエンス、２０１１ 佐藤真、山下俊英: 神経系におけるiPS細胞：iPS細胞の活用も含めた神経機能修復の現状と将来、脳２１、2011 村松里衣子、山下俊英: 多発性硬化症とRepulsive guidance molecule、脳２１、4: 401-404, 2011

2010年以前 ［ 2016年｜2015年｜2014年｜2013年｜2012年｜2011年｜2010年以前｜（2017年以降→） ］

Omoto, S., Ueno, M., Mochio, S., Takai, T. and Yamashita, T. (2010) Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury. J. Neurosci. 30, 13045-13052. Ito, Z., Sakamoto, K., Imagama, S., Matsuyama, Y., Zhang, H, Hirano, K.,Ando, K., Yamashita, T., Ishiguro, N. and Kadomatsu, K. (2010)　N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury. J. Neurosci. 30, 5937-5947. Shinohara, M., Sato, N., Kurinami, H., Takeuchi, D., Takeda, S., Shimamura, M., Yamashita, T., Uchiyama, Y., Rakugi, H. and Morishita, R. (2010) Reduction of brain Ab by Fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Ab clearance. J. Biol. Chem. 285, 22091-22102. Ishii, H., Kubo, T., Kumanogoh, A. and Yamashita, T. (2010) Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins. Biochem. Biophys. Res. Commun.Biochem. Biophys. Res. Commun. 402, 168-172. Aoki, M., Kishima, H., Yoshimura, Y., Ishihara, M., Ueno, M., Hata, K.,Yamashita, T., Iwatsuki, K. and Yoshimine, T. (2010) Transplantation of whole-layer olfactory mucosa promotes restricted functional recovery in rats with complete spinal cord injury. Journal of Neurosurgery: Spine 12,122-130. Kurihara, D., Ueno, M., Tanaka, T. and Yamashita, T. (2010) Expression of galectin-1 in immune cells and glial cells after spinal cord injury. Neurosci. Res. 66, 265-270. Nakayama, J., Takao, T., Kiuchi, H., Yamamoto, K., Fukuhara, S., Miyagawa,Y., Aoki, M., Iwatsuki, K., Yoshimine, T., Ueno, M., Yamashita, T., Nonomura, N., Tsujimura, A. and Okuyama, A. (2010) Olfactory mucosa transplantation following spinal cord injury improves voiding efficiency by suppressing detrusor sphincter dyssynergia in rats. J. Urol. 184, 775-782. 山下俊英: 中枢神経回路の修復と再生、自律神経、印刷中 山下俊英: 脊髄損傷後の神経回路のダイナミックな変化、実験医学、印刷中 Hata, K., Kaibuchi, K., Inagaki, S. and Yamashita, T. (2009) Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J. Cell Biol. 184, 737-750. Taniguchi, J., Sawai, S., Mori, M., Kubo, T., Kanai, K., Misawa, S., Isose, S., Yamashita, T. and Kuwabara, S. (2009) CIDP sera inhibit axonal growth of mouse DRG neurons by activation of Rho-kinase. Ann. Neurol. 66, 694-697. Endo, M. and Yamashita, T. (2009) Inactivation of Ras by p120GAP via FAK dephosphorylation mediates RGMa-induced growth cone collapse. J. Neurosci. 29, 6649-6662. Tanaka, T., Ueno, M. and Yamashita, T. (2009) Engulfment of axon debris by microglia requires p38 MAPK activity. J. Biol. Chem. 284, 21626-21636. Miyashita, T., Koda, M., Kitajo, K., Yamazaki, M., Takahashi, K., Kikuchi,A. and Yamashita, T. (2009) Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury. J.Neurotrauma. 26, 955-964. Fujita, Y., Yamaguchi, A. Hata, K., Endo, M., Yamaguchi, N. and Yamashita, T. (2009) Zyxin is a novel interacting partner for SIRT1. BMC Cell Biol. 10, 6. Liu, X., Hashimoto, M., Horii, H., Yamaguchi, A., Naito, K. and Yamashita, T. (2009) Repulsive guidance molecule b inhibits neurite growth and is increased after spinal cord injury. Biochem. Biophys. Res. Commun. 382, 795-800. Uesugi, N., Muramatsu, R. and Yamashita, T. (2009) Endothelin promotes neurite elongation by a mechanism dependent on c-Jun N-terminal kinase. Biochem. Biophys. Res. Commun. 383, 509-512. Kohta, M., Kohmura, E. and Yamashita, T. (2009) Inhibition of TGF-ß1 promotes functional recovery after spinal cord injury. Neurosci. Res. 65,393-401. Yamashita, M., Yamauchi, K., Suzuki, M., Eguchi, Y., Orita, S., Endo, M.,Yamashita, T., Takahashi, K. and Ohtori, S. (2009) Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain. Spine 34, 2270-2277. Yamauchi, K., Inoue, G., Koshi, T., Yamashita, M., Ito, T., Suzuki, M.,Eguchi, Y., Orita, S., Takaso, M., Nakagawa, K., Aoki, Y., Ochiai, N., Kishida, S., Endo, M., Yamashita, T., Takahashi, K. and Ohtori, S. (2009) Nerve growth factor of cultured medium extracted from human degenerative nucleus pulposus promotes sensory nerve growth and induces substance P in vitro. Spine 34, 2263-2269. Oshima, T., Lee, S., Sato, A., Oda, S., Hirasawa, H. and Yamashita, T. (2009) TNF-α contributes to axonal sprouting and functional recovery following traumatic brain injury. Brain Res. 1290, 102-110. Furuya, T.,Hashimoto, M., Koda, M., Okawa, A., Murata, A., Takahashi, K., Yamashita, T. and Yamazaki, M. (2009) Treatment of spinal cord injury with a rho-kinase inhibitor and bone marrow stromal cell transplantation. Brain Res. 1295, 192-202. Muramatsu R, Ueno M, and Yamashita T. Intrinsic regenerative mechanisms of central nervous system neurons. BioscienceTrend. 2009; 3(5):179-183. 山下俊英: 軸索伸展阻害因子と中枢神経の再生、分子脳血管病、8: 45-50, 2009 山下俊英: 脊髄の軸索再生を制御する分子群、臨床整形外科、 44: 378-380, 2009 村松里衣子、山下俊英: 中枢神経回路の再編、日本薬理学雑誌、134:46-47, 2009 山下俊英: 中枢神経回路の修復機構、脳２１、12: 306-311,2009 山下俊英: 軸索の神経化学―構造と機能、再生―、Clinical Neuroscience、27: , 1218-1220, 2009 Fujita, Y., Taniguchi, J., Uchikawa, M., Endo, M., Hata, K., Kubo, T., Mueller, B.K. and Yamashita, T. (2008) Neogenin regulates neuronal survival through DAP-kinase. Cell Death Differ.15, 1593-1608. Taniguchi, J., Fujitani, M., Endo, M., Kubo, T., Fujitani, M., Miller, F.D., Kaplan, D.R. and Yamashita, T. (2008) Rap1 is involved in the signal transduction of myelin-associated glycoprotein. Cell Death Differ.15, 408-419. Ohshima, Y., Kubo, T., Koyama, R., Ueno, M., Nakagawa, M. and Yamashita, T. (2008) Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1a. J. Neurosci.28, 8344-8353. Ohnami, S., Endo, M., Hirai, S., Uesaka, N., Hatanaka, Y., Yamashita, T. and Yamamoto, N. (2008) Role of RhoA in Activity-Dependent Cortical Axon Branching. J. Neurosci. 28, 9117-9121. Tohyama, D., Yamaguchi, A., and Yamashita, T. (2008) Inhibition of eIF2B∂/F11A3.2 during adulthood extends lifespan in Caenorhabditis elegans. FASEB J.22, 4327-4337. Matsuura, I., Taniguchi, J., Hata, K., Saeki, N. and Yamashita, T.(2008) BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. J. Neurochem. 105, 1471-1479. Kubo, T., Endo, M., Hata, K., Taniguchi, J., Kitajo, K., Tomura, S.,Yamaguchi, A., Mueller, B.K. and Yamashita, T. (2008) Myosin IIA is required forneurite outgrowth inhibition produced by RGMa. J. Neurochem.105, 113-126. Schaffer, G., Taniguchi, J., Brodbeck, T., Meyer, A.H., Schmidt, M., Yamashita, T. and Mueller, B.K. (2008) LIM-Only-Protein 4 (LMO4) interacts directly with the RGM A Receptor Neogenin. J. Neurochem. 107, 418-431. Watanabe, T., Ito, T., Inoue, G., Ohtori, S., Kitajo, K., Doya, H., Takahashi, K. and Yamashita, T. The p75 receptor is associated with inflammatory thermal hypersensitivity. J. Neurosci. Res. 86, 3566-3574. Yoshida, J., Kubo, T. and Yamashita, T. Inhibition of branching and spine maturation by repulsive guidance molecule in cultured cortical neurons. Biochem. Biophys. Res. Commun.372, 725-729. Kawaguchi, K., Ishiwata, S. and Yamashita, T. (2008) Temperature dependence of the flexural rigidity of single microtubules. Biochem Biophys Res Commun.366, 637-642. Suda, M., Hata, K., Sawada, A., Nakamura, Y., Kubo., Yamaguchi, A. and Yamashita, T.(2008) Peptides derived from repulsive guidance molecule act as antagonists. Biochem Biophys Res Commun.371, 501-504. Ueno, M. and Yamashita, T. (2008) Strategies for regenerating injured axons after spinal cord injury-insights from brain development. Biologics: Targets & Therapy.2, 253-264. Kubo, T., Yamaguchi, A., Iwata, N. and Yamashita, T. (2008) The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. Therapeutics and Clinical Risk Management. 4, 605-615. 山下俊英: 軸索再生阻害機構とその制御による中枢神経再生治療、蛋白質・核酸・酵素　増刊号「神経の分化、回路形成、機能発現」、53: 406-410, 2008 山下俊英: 中枢神経の再生、脳２１、11: 125-129, 2008 山下俊英: 中枢神経損傷後の機能回復と神経回路の再生、日本整形外科学会雑誌、82: 895-900, 2008 山下俊英: 中枢神経と末梢神経の再生、第１７回国際痒みシンポジウム記録集、2008 山下俊英: 神経回路修復の分子機構とリハビリテーションへの期待、脳科学とリハビリテーション、8: 2008 田中達英、山下俊英: 脳・脊髄はなぜ再生しないのか、脳死・脳蘇生、2008 村松里衣子、山下俊英: 中枢神経損傷後の機能回復と神経回路の修復機構、再生医療、7: 371-374, 2008 Yamashita, T., Mueller, B.K. and Hata, K. (2007) Neogenin and RGM signaling in the central nervous system Curr. Opin. Neurobiol. 17, 29-34. Kubo, T., Hata, K., Yamaguchi, A. and Yamashita, T. (2007) Rho-ROCK inhibitors as emerging strategies to promote nerve regeneration. Curr. Pharm. Des. 13, 2493-2499. Matsuura, I., Endo, M., Hata, K., Kubo, T., Yamaguchi, A., Saeki, N. and Yamashita, T. (2007) BMP inhibits neurite growth by a mechanism dependent on LIM-kinase. Biochem. Biophys. Res. Commun. 360, 868-873. Kyoto, A., Hata, K. and Yamashita, T. (2007)Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury. Brain Res.1186, 74-86. Ito, T., Ohtori, S., Hata, K., Inoue, G., Moriya, H., Takahashi, K. and Yamashita, T. (2007) Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis. Spine 32, 2070-2075. Kaneko, M., Kubo, T., Hata, K., Yamaguchi, A. and Yamashita, T. (2007) Repulsion of cerebellar granule neurons by chondroitin sulfate proteoglycans is mediated by MAPK pathway. Neurosci. Lett. 423, 62-67. Kubo, T., and Yamashita, T. (2007) Rho-ROCK inhibitors for the treatment of CNS injury. Recent Patents on CNS Drug Discovery 2, 173-179. Endo, M., and Yamashita, T. (2007) Inhibition of Rho/Rho-kinase as therapeutic strategy to promote CNS axonal regeneration. Central Nervous System Agents in Medicinal Chemistry 7, 241-250. 山下俊英、羽田克彦、山口淳、久保武一: 中枢神経回路の再生と可塑性、蛋白質・核酸・酵素、52: 11-17, 2007 山下俊英: 軸索再生阻害機構の制御による脊髄損傷治療、脳２１、10: 15-19, 2007 山下俊英、羽田克彦、山口淳、久保武一: 中枢神経回路の軸索再生への戦略、脳神経外科、35: 733-739, 2007 山下俊英: 中枢神経障害におけるRhoキナーゼ活性異常の病態形成への関与、臨床薬理の進歩、28: 110-116, 2007 山下俊英: 軸索再生阻害機構の分子機構とその制御、BRAIN and NERVE、59: 1347-1353, 2007 Hata, K., Fujitani, M., Yasuda, Y., Doya, H., Saito, T., Yamagishi, S., Mueller, B.K. and Yamashita, T. (2006) RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J. Cell Biol. 173,47-58 Mimura, F., Yamagishi, S., Arimura, N., Fujitani, M., Kubo, T., Kaibuchi, K.and Yamashita, T. (2006) MAG inhibits microtubule assembly by a Rho-kinasedependent mechanism. J. Biol. Chem. 281, 15970-15979. Mueller, B.K., Yamashita, T., Schaffer, G. and Mueller, R. (2006) The Role of Repulsive Guidance Molecules (RGMs) in the Embryonic and Adult Vertebrate Central Nervous System. Proc. R. Soc. Lond. Ser. B-Biol. Sci. 361, 1513-1529. Nishio, Y., Koda, M., Kitajo, K., Seto, M., Hata, K., Taniguchi, J., Moriya, H., Fujitani, M., Kubo, T. and Yamashita, T. (2006) Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats. Exp. Neurol. 200, 392-397. Hiraga, A., Kuwabara, S., Douya, H., Kanai, K., Fujitani, M., Taniguchi, J., Arai, K., Mori, M., Hattori, T., and Yamashita, T. (2006) Rho-kinase inhibition enhances axonal regeneration and functional recovery after peripheral nerve injury. J. Peripher. Nerv. Syst. 11, 217-224. Hata, K., Kubo, T., Yamaguchi, A. and Yamashita, T. (2006) Signaling mechanisms of axon growth inhibition. Drug News Perspect. 19, 541-547. Maeda, Y., Fujimura, L., O-Wang, J., Hatano, M., Sakamoto, A., Arima, M.,Ebara, M., Ino, H., Yamashita, T., Saisho, H. and Tokuhisa, T. (2006) Role of Clast1 in development of cerebellar granule cells. Mol. Brain Res. 1104,18-26. Sato, T., Doi, K., Taniguchi, M., Yamashita, T., Kubo, T. and Tohyama, M.(2006) Progressive hearing loss in mice carrying a mutation in the p75 gene. Brain Res. 1091, 224-234. Doya, H., Ito, T., Hata, K., Fujitani, M., Ohtori, S., Saito-Watanabe, T.,Moriya, H., Takahashi, K., Kubo, T. and Yamashita, T. (2006) Induction ofrepulsive guidance molecule in neurons following sciatic nerve injury. J.Chem. Neuroanat. 32, 74-77. Saito-Watanabe, T., Ohtori, S., Koda, M., Aoki, Y., Doya, H., Shirasawa, H., Yamazaki, M., Moriya, H., Takahashi, K. and Yamashita, T. (2006) Adenoviral Gene Transfer in the Peripheral Nervous System. J. Orthopaedic Sci. 11,64-69 山下俊英、羽田克彦、山口淳、久保武一: 中枢神経再生の可能性、日本臨床、2006 Yamagishi, S., Fujitani, M., Hata, K., Kitajo, K., Mimura, F., Abe, H. and Yamashita, T. (2005) Wallerian degeneration involves Rho/Rho-kinase signaling. J. Biol. Chem. 280, 20384-20388. Yamashita, T., Fujitani, M., Yamagishi, S., Hata, K. and Mimura, F. (2005) Multiple signals regulate axon regeneration through the Nogo receptor complex. Mol. Neurobiol. 32, 105-112. Fujitani, M., Kawai, H., Proia, R.L., Kashiwagi, A., Yasuda, H. and Yamashita, T. (2005) Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction. J. Neurochem. 94, 15-21. Fujitani, M., Honda, A., Hata, K., Yamagishi, S., Tohyama, M. and Yamashita, T. (corresponding author) (2005) Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts. Biochem. Biophys. Res. Commun. 327, 150-154. Doya, H., Ohtori, S., Fujitani, M., Saito, T., Hata, K., Ino, H., Takahashi, K., Moriya, H. and Yamashita, T. (corresponding author) (2005) c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity. Biochem. Biophys. Res. Commun. 335, 132-138. Doya, H., Ohtori, S., Takahashi, Ka., Aoki, Y., Ino, H., Takahashi, Y., Moriya, H. and Yamashita, T. (2005) ERK MAP kinase activation in the dorsal root ganglion (DRG) and the spinal cord following DRG injury in rats. Spine 30, 2252-2256. Yamashita, T., Fujitani, M., Hata, K., Mimura, F. and Taniguchi, J. (2005) Rho/Rho-kinase as potential therapeutic targets for CNS injury. Gene Therapy and Molecular Biology 9, 265-268. Yamashita, T., Fujitani, M., Hata, K., Mimura, F. and Yamagishi, S. (2005) Diverse functions of the p75 neurotrophin receptor. Anat. Sci. Int. 80, 37-41. 山下俊英、藤谷昌司、羽田克彦, 山岸覚: 中枢神経の軸索再生のメカニズム、蛋白質・核酸・酵素, 50: 403-409, 2005 山下俊英、藤谷昌司、羽田克彦: 脳・脊髄はなぜ再生しないのか、千葉医学雑誌, 81: 117-118, 2005 山下俊英、藤谷昌司、羽田克彦、三村文昭: 中枢神経再生阻害の分子機構：軸索再生の可能性、生化学、77: 1475-1480, 2005 山下俊英、藤谷昌司: 軸索伸展阻害因子と中枢神経再生、医学のあゆみ、215: 851-854, 2005 山下俊英、藤谷昌司、羽田克彦、三村文昭: 中枢神経系の再生とRho/Rho-kinaseの役割、脳卒中の外科、33: 395-397, 2005 Hasegawa, Y., Fujitani, M., Hata, K., Tohyama, M., Yamagishi, S. and Yamashita, T. (2004) Promotion of axon regeneration by MAG and Nogo through divergent signals downstream of Gi/G. J. Neurosci. 24, 6826-6832. Hasegawa, Y.,Yamagishi, S.,Fujitani, M. and Yamashita, T. p75 neurotrophin receptor signaling in the nervous system. Biotech. Annual Review 10, 123-149. Madura, T., Yamashita, T. (corresponding author), Kubo, T., Fujitani, M., Hosokawa, K. and Tohyama, M. (2004) Activation of Rho in the injured axons following spinal cord injury. EMBO Reports 5, 412-417. Aoki, M., Yamashita, T. (corresponding author) and Tohyama, M. 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