2007
234) Nakaoka, Y., K.Nishida, M. Narimatsu, A. Kamiya, T.Minami, H. Sawa, K. Okawa, Y. Fujio, T. Koyama, M. Maeda, M. Sone, S. Yamasaki, Y. Arai, G. Y. Koh, T. Kodama, H. Hirota, K. Otsu, T. Hirano, and N. Mochizuki. Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling. J. Clin. Invest. in press (PubMed)
233) *Nishihara, M., *H. Ogura, N. Ueda, M. Tsuruoka, C. Kitabayashi, F. Tuji, H. Aono, K. Ishihara, E. Huseby, U. A.K.Betz, M. Murakami and T. Hirano. IL-6-gp130-STAT3 in T cells directs the development of IL-17+T helper cells with a minimum effect on that of Treg in the steady state. Int. Immunol. in press (PubMed) (*equal contribution)
232) Yamasaki, S., K. Sakata-Sogawa, A. Hasegawa, T. Suzuki, K. Kabu, E. Sato, T. Kurosaki, S. Yamashita, M. Tokunaga, K. Nishida and T. Hirano. Zinc is a novel intracellular second messenger. J. Cell Biol. in press (PubMed)
231) *Khiong, K., *M. Murakami, C. Kitabayashi,N. Ueda, S. Sawa, A. Sakamoto, B. L. Kotzin, S. J. Rozzo, K. Ishihara, M. Verella-Garcia, J. Kappler, P. Marrack, and T. Hirano. Homeostatic proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model. J. Clin. Invest. in press (*equal contribution)
230) Kagara, N., N. Tanaka, S. Noguchi, and T. Hirano. Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. Cnacer Science. in press (PubMed)
2006
229) Kamon, H., T. Kawabe, H. Kitamura, D. Kamimura, G.-H. Jin, T. Kaisyo, S. Akira, A. Iwamatsu, H. Koga, K. Ishihara, M. Murakami and T. Hirano. TRIF-GEFH1-RhoB cascade regulates surface expression of MHC class II in dendritic cells that is critical for CD4+ T cell activation. EMBO J. 25:4108-4119, 2006. Epub 2006 Aug 17 (PubMed)
228) Ueda, N., H. Kuki, D. Kamimura, S. Sawa, K. Seino, M. Taniguchi, T. Hirano and M. Murakami. CD1d-restricted natural killer T cell activation enhanced homeostatic proliferation of CD8+T cells in a manner dependent on IL-4. Int. Immunol.18:1397-1404, 2006. Epub 2006 Aug 16 (Published online: 16 August 2006) (PubMed)
227) Kitamura, H., H. Morikawa, H. Kamon, M. Iguchi, S. Hojyo, T. Fukada, S. Yamashita, T. Kaisho, S. Akira, M. Murakami and T. Hirano. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nature Immunol.7:971-977, 2006 (Published online: 6 August 2006; | doi:10.1038/ni1373) (Research Highlights in Nature, 17 August 2006 Nature 442, 722, 2006) (RIKEN RESEARCH September Vol.1 No. 3) (Spotlight of ACS Chemical Biology) (PubMed)
226) Kabu, K., S. Yamasaki, D. Kamimura, Y. Ito, A. Hasegawa, E. Sato, H. Kitamura, K. Nishida, and T. Hirano. Zinc is required for FceRI-mediated mast cell activation. J. Immunol. 177:1296-1305, 2006. (PubMed)
225) Kamimura, D., Y. Sawa, M. Sato, E. Agung, T. Hirano, and M. Murakami. IL-2 in vivo activities and anti-tumor efficacy enhanced by an anti-IL-2 mAb. J. Immunol. 177:306-314, 2006 (PubMed)
224) Sawa, S., D. Kamimura, G.-H. Jin, H. Morikawa, H. Kamon, M. Nishihara, K. Ishihara, M. Murakami, and T. Hirano. Autoimmune arthritis associated with mutated IL-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T. J. Exp. Med. 203:1459-1470, 2006. published on line 22 May 2006, 10.1084/jem.20052187. (In This Issue) (J Exp Med) (Research Highlights in Nature Reviews Immunology July 2006) (PubMed)
Review-79) Hirano, T. and M. Murakami. Grasp a pTyr-peptide by its SOCS. Dev. Cell 10:542-544, 2006 (PubMed)
2005
223) Kitamura, H., H. Kamon, S. Sawa, S-J. Park, N. Katsunuma, K. Ishihara, M. Murakami and T. Hirano. IL-6-STAT3 controls intracellular MHC classII ab-dimer level through Cathepsin S activity in dendritic cells. Immunity, 23: 491-502, 2005. (PubMed). (Immunity) (Science's STKE) (Research Highlights in Nature Immunology 7:17,2006)
222) Nishida, K., S. Yamasaki, Y. Ito, K. Kabu, K. Hattori, T. Tezuka, H. Nishizumi, D. Kitamura, R. Goitsuka, R.S. Geha, T. Yamamoto, T. Yagi, T. Hirano. FceRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J. Cell Biol. 170:115-126, 2005 (PubMed). (JCB) (In This Issue)
2004
221) Kamimura, D., N. Ueda, S. Hachida, T. Atsumi, T. Nakagawa, S. Sawa, H. Suzuki, K. Ishihara, M. Murakami, T. Hirano. Evidence of a novel IL-2/15Rbeta-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. J. Immunol. 173:6041-6049, 2004. (PubMed).
220）Esashi E, Ito H, Ishihara K, Hirano T, Koyasu S, Miyajima A. Development of CD4+ Macrophages from Intrathymic T Cell Progenitors Is Induced by Thymic Epithelial Cells. J Immunol. 173: 4360-4367, 2004. (PubMed)
219) Miyagi, C., S. Yamashita, Y. Ohba, H. Yoshizaki, M. Matsuda, and T. Hirano. STAT3 non-cell-autonomously controls planner cell polarity during zebrafish convergence and extention. J. Cell Biol., 166: 975-981, 2004. (PubMed)
218) Park, Sung-Joo, Takayuki Nakagawa, Hidemitsu Kitamura, Toru Atsumi, Hokuto Kamon, Shin-ichiro Sawa, Daisuke Kamimura, Naoko Ueda, Yoichiro Iwakura, Katsuhiko Ishihara, Masaaki Murakami, and Toshio Hirano. IL-6 Regulates in vivo Dendritic Cell Differentiation through STAT3 Activation. J. Immunol. 173：3844-3854, 2004. (PubMed)
217) Morii E, Oboki K, Ishihara K, Jippo T, Hirano T, Kitamura Y. Roles of MITF for Development of Mast Cells in Mice: Effects on Both Precursors and Tissue Environments. Blood. 104:1656-1661, 2004. (PubMed)
216) Ozawa Y, Nakao K, Shimazaki T, Takeda J, Akira S, Ishihara K, Hirano T, Oguchi Y, Okano H. Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol Cell Neurosci. 2004 Jun;26(2):258-70. (PubMed)
215) Hirata T, Suda Y, Nakao K, Narimatsu M, Hirano T, Hibi M. Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons. Dev Dyn. 2004 Jul;230(3):546-56. (PubMed)
214) Bae YK, Shimizu T, Muraoka O, Yabe T, Hirata T, Nojima H, Hirano T, Hibi M. Expression of sax1/nkx1.2 and sax2/nkx1.1 in zebrafish. Gene Expr Patterns. 2004 Jul;4(4):481-6. (PubMed)
213）Yamashita, S., C. Miyagi, T. Fukada, N. Kagara, Y.-S. Che & T. Hirano. Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature 429: 298-302, 2004, published online 5 May 2004; doi:10.1038/nature02545 (PubMed) (Nature)
212) Nojima H, Shimizu T, Kim CH, Yabe T, Bae YK, Muraoka O, Hirata T, Chitnis A, Hirano T, Hibi M.. Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. Mech Dev. 121:371-86. 2004. (PubMed)
211) Ishihara, K. , Shin-ichiro Sawa, Hideto Ikushima, Seiichi Hirota, Toru Astumi, Daisuke Kamimura, Park Sung-Joo, Masaaki Murakami, Yukihiko Kitamura, Yoichiro Iwakura, and Toshio Hirano. The point mutation of Y759 of the IL-6 family receptor gp130 synergizes with HTLV-1 pX in promoting RA-like arthritis. Int. Immunol. 16: 455-465, 2004. (PubMed) (Int. Immunol)
210）Kallin A, Demoulin JB, Nishida K, Hirano T, Ronnstrand L, Heldin CH. Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor. J Biol Chem. 2004 Feb 17 [Epub ahead of print] (PubMed)
Review-78) Murakami, M., Kamimura, D., and Hirano, T. New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Facotrs 22:75-77, 2004.
Review-77) Ohtani, T. and Hirano, T. Interleukin -6 in Encyclopedia of Endocrinology and Endocrine Diseases, edited by Martini, L., Academic Press,pp64-70, 2004.
2003
209）Nakaoka, Y., Nishida, K., Fujio, Y., Izumi, M., Terai, K., Oshima, Y., Sugiyama, S., Matsuda, S., Koyasu, S., Yamauchi-Takihara, K., Hirano, T., Kawase, I., and Hirota, H. Activation of gp130 Transduces Hypertrophic Signal through Interaction of Scaffolding/Docking Protein Gab1 with Tyrosine Phosphatase SHP2 in Cardiomyocytes" Circulation Research, 93:221-229, 2003 (PubMed)
208）HYasukawa, MOhishi, HMori, MMurakami, TChinen, DAki, THanada, KTakeda, SAkira, MHoshijima, THirano, KRChien & AYoshimura. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nature Immunology, 4: 551-556, 2003. (PubMed).
207) Yabe T, Shimizu T, Muraoka O, Bae YK, Hirata T, Nojima H, Kawakami A, Hirano T, Hibi M. Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling. Development. 130:2705-16, 2003. (PubMed)
206) Bae YK, Shimizu T, Yabe T, Kim CH, Hirata T, Nojima H, Muraoka O, Hirano T, Hibi M. A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish. Development 130:1853-1865, 2003. (PubMed)
205）Yamasaki S, Nishida K, Sakuma M, Berry D, McGlade CJ, Hirano T, Saito T. Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. Mol Cell Biol. 23:2515-29, 2003 (PubMed)
204) Yamasaki, S., K. Nishida, Y. Yoshida, M. Hibi, and T. Hirano, Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. Oncogene, 13：1546-1556，2003 (PubMed)
Review-76) Yamashita, S. and Hirano, T. Stats in cell mobility and polarity during morphogenetic movement. in Signal Transducers and Activators of Transcription (STATs):Activation and Biology, edited by P. B. Sehgal, D. E. Levy and T. Hirano, Kluwer Academic Publishers, pp595-607, 2003.
Review-75) Kamimura, D. and Hirano, T. Mechanisms and biological roles of STAT activation by the IL-6 family of cytokines. in Signal Transducers and Activators of Transcription (STATs):Activation and Biology, edited by P. B. Sehgal, D. E. Levy and T. Hirano, Kluwer Academic Publishers, pp155-175, 2003.
Review-74) Kamimura, D., Ishihara, K., and Hirano, T. IL-6 signal transduction and its physiological roles:The signal orchestration model. Reviews of Physiology, Biochemistry and Pharmacology, 149：1-38, 2003. (PubMed)
Review-73) Nishida, K., and Hirano, T. The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors. Cancer Science 94: 1029-1033, 2003. (PubMed)
Review-72) Kamimura D., and Hirano, T. Interleukin-6 in Encyclopedia of Hormones, edited by Henry, H. L, and Norman, A. W., Elsevier Science, pp430 - 439, 2003.
2002
203) Cai, T., K. Nishida, T. Hirano and P. Khavari. Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation. J. Cell Biol. 159:103-112, 2002 (PubMed)
202) Shimizu, T., Y. Yamanaka, H. Nojima, T. Yabe, M. Hibi, and T. Hirano. A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Mechanisms of Development, 118: 125-138, 2002 (PubMed)
201) Matsui T, Kinoshita T, Hirano T, Yokota T, Miyajima A. STAT3 down-regulates the expression of cyclin D during liver development. J Biol Chem. 277:36167-36173, 2002 (PubMed)
200) Atsumi, T*., K. Ishihara*, D. Kamimura, H. Ikushima, T. Ohtani, S. Hirota, H. Kobayashi, S-.J. Park, Y. Saeki, Y. Kitamura, and T. Hirano. (*equal contribution). A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J. Exp Med. 196: 979-990, 2002 (PubMed),introduced by Nature Immunology Nov.issue, 2002
199) Itoh, S., M. Itoh, K. Nishida, S. Yamasaki, Y. Yoshida, M. Narimatsu, S. J. Park, M. Hibi, K. Ishihara, and T. Hirano. Adapter molecule Gab1 is specifically expressed in marginal zone B cells and negatively regulates TI-2 responses. J. Immunol. 168:5110-5116, 2002. (PubMed). RCAI
198) Kamimura, D., D. Fu, Y. Matsuda, T. Atsumi, T. Ohtani, S. J. Park, K. Ishihara, T. Hirano. Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility. Genes and Immunity. 3: 136-143, 2002. (PubMed), RCAI
197) Yamashita, S., C. Miyagi, A. Carmany-Rampey, T. Shimizu, R. Fujii, A. F. Schier and T. Hirano. Stat3 controls cell movements during zebrafish gastrulation. Dev. Cell. 2: 363-375, 2002.(PubMed) (Evaluations and comments from leading biologists)
196) Yamamoto-Katayama S, Ariyoshi M, Ishihara K, Hirano T, Jingami H, Morikawa K. Crystallographic Studies on Human BST-1/CD157 with ADP-ribosyl Cyclase and NAD Glycohydrolase Activities. J Mol Biol 316: 711-23, 2002. (PubMed)
195) Nishida, K*., L. Wang, E*., Mori, S.-J. Park, M. Narimatsu, S. Itoh, S. Yamasaki, M. Fujishima, K. Ishihara, M. Hibi, Y. Kitamura, and T. Hirano (*equal contribution). Requirement of Gab2 for mast cell development and Kitl/c-Kit signaling. Blood. 99:1866-1869, 2002.(PubMed) RCAI
Review-71) Hirano, T. Cytokines in autoimmune disease and chronic inflammatory proliferative disease. edited by Hirano, T. Editorial for Cytokine Growth Factor Rev, 13：297-298, 2002. (PubMed), RCAI
Review-70) Ishihara, K., and Hirano, T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev, 13:357-368, 2002. (PubMed), RCAI
Review-69) Ishihara, K., and Hirano, T. The molecular basis of the cell-specificity of cytokine action. Biochim Biophys Acta. 1592:281-96,2002, (PubMed) RCAI
Review-68) Hirano, T. Revival of the autoantibody model in rheumatoid arthritis. Nature Immunology 3:342-344, 2002, (PubMed), RCAI
Review-67) Hibi, M., Hirano, T., and Dawid I. B. Organizer formation and function. Results Probl Cell Differ 40: 48-71. 2002 (PubMed)
2001
194) Yamasaki, S., K. Nishida, M. Hibi, M. Sakuma, R. Shiina, A. Takeuchi, H. Ohnishi, T. Hirano, and T. Saito. Docking protein Gab2 is phophorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. J. Biol. Chem. 276:45175-45183, 2001. (PubMed)
193) Narimatsu, M., H. Maeda, S. Itoh, T. Atsumi, T. Ohtani, K. Nishida, M. Itoh, D. Kamimura, S.-J. Park, K. Mizuno, J. Miyazaki, M. Hibi, K. Ishihara, K. Nakajima and T. Hirano. Tissue-specific autoregulation of the stat3 gene and its role in interleukin 6-induced survival signals in T cells. Mol. Cell. Biol. 21:6615-6625, 2001 (PubMed).
192) Yamada, K., Nishida, K., Hibi, M., Hirano, T. and Matsuda, Y. Comparative FISH mapping of Gab1 and Gab2 genes in human, mouse and rat. Cytogenetics and Cell Genetics, 94:39-42, 2001. (PubMed)
191) Yamamoto-Katayama, S., A. Sato, M. Ariyoshi, M. Suyama, K. Ishihara, T. Hirano, H. Nakamura, K. Morikawa and H. Jingami. Site-directed removal of N-glycocylation sites in BST-1/CD157: effects on molecular and functional heterogeneity. Biochem. J. 357: 385-392, 2001.(PubMed)
190) Kojima H, Shinagawa A, Shimizu S, Kanada H, Hibi M, Hirano T, Nagasawa T. Role of phosphatidylinositol-3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function. Exp Hematol. 29:616-22, 2001(PubMed)
189) Abe, K., M. Hirai, K. Mizuno, N. Higashi, T. Sekinoto, T., Miki, T. Hirano and K. Nakajima. The YXXQ motif in gp130 is crucial for STAT3 phosphorylation at Sser727 through an H7-sensitive kinase pathway. Oncogene14:3464-3474, 2001.(PubMed)
188) Mizuno, K., T. Shirogane, A. Shinohara, A. Iwamatsu, M. Hibi, and T. Hirano. Regulation of pim-1 by Hsp90. BBRC 281:663-669, 2001 (PubMed)
187) Ryu, S.-L., R. Fujii, Y. Yamanaka, T. Shimizu, T. Yabe, T. Hirata, M. Hibi, and T. Hirano. Regulation of dharma/bozozok by the Wnt pathway. Dev. Biol. 2001 231:397-409, 2001 (PubMed)
Review-66) Hibi, M., and Hirano, T. IL-6 receptor. Cytokine Reference, edited by Oppenheim, J. J., Feldmann, M., Durum, S. K., Hirano, T., Vilcek, J., Nicola, N.A. Academic Press. Vol. 2, pp1761-1778. 2001. (On line)
Review-65) Matsuda, T. and Hirano, T. IL-6. Cytokine Reference, edited by Oppenheim, J. J., Feldmann, M., Durum, S. K., Hirano, T., Vilcek, J., Nicola, N.A. Academic Press. Vol. 1, pp537-563. 2001.(On line)
Review-64) Hirano, T., and Fukada, T. IL-6 ligand and receptor family. Cytokine Reference, edited by Oppenheim, J. J., Feldmann, M., Durum, S. K., Hirano, T., Vilcek, J., Nicola, N.A. Academic Press. Vol. 1, pp523-535. 2001. (On line)
2000
186) Muraoka, O., Ichikawa, H., Shi, H., Okamura, S., Taira, E., Higuchi, H., Hirano, T., Hibi, M., and Miki, N. Kheper, a novel ZFH/dEF1 family, regulates the development of the neuroectoderm of zebrafish (Danio rerio). Dev. Biol. 228:29-40, 2000.(PubMed)
185) Park, H-C., Kim, C-H., Bae, Y-K., Yeo, S-Y., Kim, S-H., Hong, S-K., Shin, J., Hibi, M., Hirano, T., Miki, N., Chitnis, A.B., and Huh, T-L. Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons. Dev. Biol. 227:279-293, 2000. (PubMed)
184) Fujii, R., S. Yamashita, M. Hibi, and T. Hirano. Asymmetric p38 activation in zebrafish; its possible role in symmetric and synchronous cleavage. J. Cell Biol. 150:1335-1347, 2000 (PubMed) (Full Text in JCB). This is mentioned in the "In Brief" of the JCB.
183) Hashimoto, H., T., Yabe, T. Hirata, T. Shimizu, Y.-K. Bae, Y. Yamanaka, T. Hirano, and M. Hibi. Expression of the zinc finger gene fez-like in zebrafish forebrain. Mechanisms of Development, 97:191-195, 2000 (PubMed)
182) Odajima, J., I. Matsumura, J. Sonoyama, H. Daino, A. Kawasaki, H. Tanaka, N. Inohara, T. Kitamura, J. Downward, K. Nakajima, T. Hirano, and Y. Kanakura. Full oncogenic activities of v-Src are mediated by multiple signaling pathways. J. Biol. Chem. 275:24096-24105, 2000.(PubMed)
181) Hirata, T., Y. Yamanaka, S.-L. Ryu, T. Shimizu, T. Yabe, M. Hibi, and T. Hirano. Novel mix-family homeobox genes in zebrafish and their differential regulation. BBRC, 271:603-609, 2000.(PubMed).
180) Itoh, M., Yoshida, Y., Nishida, K., Narimatsu, M., Hibi, M., and Hirano, T. A role of Gab1 for heart, placenta, and skin development, and growth factors- and cytokines-induced ERK MAP kinase activation. Mol. Cell. Biol. 20, 3695-3704, 2000.(PubMed)(Abstract)(Full Text in MCB)
179) Daino, H., I. Matsumura, K. Takada, J. Oajima, H. Tanaka, S. Ueda, H. Shibayama, H. Ikeda, M. Hibi, T. Hirano, and Y. Kanakura. Induction of apoptosis by extracellular ubiquitin in human hematopoietic cells: possible involvement of STAT3 degradation by proteasome pathway in interleuikin 6-dependent hematopoietic cells. Blood, 95, 2577-2585, 2000. (PubMed)
178) Shimizu, T., Y. Yamanaka, S.-L. Ryu, H. Hashimoto, T. Yabe, T. Hirata, Y.-K. Bae, M. Hibi, and T. Hirano. Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish. Mechanisms of Development, 91, 293-303, 2000.(Full Text)(PubMed)
177) Tanaka, H., Matsumura, I., Nakajima, K., Daino, H., Sonoyama, J., Yoshida, H., Oritani, K., Machii, T., Yamamoto, M., Hirano, T., Kanakura, Y. GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and Bcl-2 in a murine myeloid cell line M1. Blood 95,1264-1273, 2000. (Blood)(PubMed)
176) Ohtani, T., K. Ishihara, T. Atsumi, K. Nishida, Y. Kaneko, T. Miyata, S. Itoh, M. Narimatsu, H. Maeda, T. Fukada､, M. Itoh, H. Okano, M. Hibi and T. Hirano. Dissection of signaling cascades through gp130 in vivo: Reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity, 12, 95-105, 2000. (PubMed) (Full Text in Immunity)
175) Hashimoto, H., M. Itoh, Y. Yamanaka, S. Yamashita, T. Shimizu, L. Solnica-Krezel, M. Hibi, and T. Hirano. Zebrafish Dkk1 Functions in Forebrain Specification and Axial Mesendoderm Formation. Developmental Biology 217, 138-152, 2000.(Abstract)(PubMed)
Review-63) Ohtani, T., K. Ishihara, T. Atsumi, Y. Yoshida, K. Nishida, M. Narimatsu, T. Shirogane, M. Hibi and T. Hirano. gp130-mediated signalings as therapeutic targets. Emerging Therapeutic Targets,4, 459-479, 2000.
Review-62) Hirano, T., K. Ishihara, M. Hibi. Roles of STAT3 in mediating the cell growth, differentiation, and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene, 19: 2548-2556, 2000. (PubMed)
Review-61) Hibi, M., and Hirano, T. Gab-family adapter molecules in signal transduction of cytokine and growth factor receptors, and T and B cell antigen receptors. Leukemia and Lymphoma, 37, 299-307, 2000. (PubMed)
Review-60) Ishihara, K., and T. Hirano. BST-1/CD157 regulates the humoral immune responses in vivo. Chemical Immunol75, 235-255, 2000.(PubMed)
1999
174) Shirogane, T., T. Fukada, J.M.M. Muller, D. T. Shima, M. Hibi, and T. Hirano, Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and anti-apoptosis. Immunity 11, 709-719, 1999. (PubMed) (Full Text in Immunity)
173) Wickrema, A., Uddin, Ss., Sharma, A., Chen, F., Alsayed, Y., Ahmad, S., Sawyer, S. T., Krystal, G., Yi, T., Nishida, K., Hibi, M., Hirano, T., and Platanias, L. C. Engagement of Gab1 and Gab2 in erythropoietin signaling. J. Biol. Chem. 274, 24469-24474, 1999.(PubMed)
172) Nakayama, K., Hara, T., Hibi, M., Hirano, T., and Miyajima, A. A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth. J . Biol. Chem. 274, 24766-24771, 1999.(PubMed)
171) Kortylewski, M., Heinrich, P.C., Mackiewicz, A., Schniertshauer, U., Klingmuller, U., Nakajima K., Hirano, T., Horn F., and Behrmann, I. Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1. Oncogene 18, 3742-3753, 1999. (PubMed).
170) Ohtomo, T., Sugamata, Y., Ozaki, Y., Ono, K., Yoshimura, Y., Kawai, S., Koishihara, Y., Ozaki, S., Kosaka, M., Hirano, T., and Tsuchiya, M. Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myelom cells. Biochem. Biophys. Res. Comm., 258, 583-591, 1999.
169) Fekany, K., Y. Yamanaka, T. Leung, H. I. Sirotkin, J. Topczewski, M. A. Gates, M. Hibi, A. Renucci, D. Stemple, A. Radbill, A. F. Schier, W. Driver, T. Hirano, W. S. Talbot, and L. Solnica-Krezel. The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development, 126:1427-1438, 1999. (Development), (PubMed)
168) Nishida, K., Y. Yoshida, M. Itoh, T. Fukada, T. Ohtani, T. Shirogane, T. Atsumi, M. Takahashi-Tezuka, K. Ishihara, M. Hibi, and T. Hirano. Gab-family adapter proteins act downstream of cytokine and growth factor receptors, and T and B cell antigen receptors. Blood, 93:1809-1816, 1999.(PubMed)
167) Oritani, K., Y. Tomiyama, P.W. Kincade, K. Aoyama, T. Yokota, I. Matsumura, Y. Kanakura, K. Nakajima, T. Hirano, and Y. Matsuzawa. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood, 93:1346-1354. 1999. (PubMed)
166) Sato, A., S. Yamamoto, K. Ishihara, T. Hirano, and H. Jingami. Novel peptide inhibitor of ecto-ADP-ribosyl cyclase of bone marrow stromal cell antigen-1(BST-1/CD157). Biochemical J. 337:491-496, 1999. (PubMed)
165) Kiuchi, N., K. Nakajima, M. Ichiba, T. Fukada, M. Narimatsu, K. Mizuno, M. Hibi, and T. Hirano. STAT3 is required for the gp130-mediated full activation of the c-myc gene. J. Exp. Med. 189: 63-73, 1999 (Abstract)(PubMed)
Review-59) Fukada, T., Y. Yoshida, K. Nishida, T. Ohtani, T. Shirogane, M. Hibi, and T. Hirano. Signaling through gp130: Toward a general scenario of cytokine action. Growth Factors 17, 81-91, 1999. (PubMed)
Review-58) Hirano, T. Molecular basis underlying functional pleiotropy of cytokines and growth factors. Biochem. Biophys. Res. Comm., 260, 303-308, 1999 (PubMed).
1998
164) Fukada, T., T. Ohtani, Y. Yoshida, T. Shirogane, K. Nishida, K. Nakajima, M. Hibi, and T. Hirano. STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell cycle transition. EMBO J. 17: 6670-6677,1998 (Abstract)(PubMed) (Full Text in EMBO J).
163) Itoh, M., K. Ishihara, T. Hiroi, B. Ok Lee, H. Maeda, H.
Iijima, M. Yanagita, H. Kiyono, and T. Hirano. Deletion of
BST-1(CD157) gene impaired systemic TI-2 antigen-induced IgG3 and
mucosal TD antigen-elicited IgA responses.
J. Immunol. 161: 3974-3983, 1998.
(Abstract)
(J.
Immunol)(PubMed)(Full
Text in JI)
162) Shimaoka, Y., J. F. Attrep, T. Hirano, K. Ishihara, R. Suzuki, T. Toyosaki, T. Ochi, and P. E. Lipsky. Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells. J. Clin. Invest. 102, 606-618, 1998. (PubMed)(Full Text in JCI)
161) Yamanaka, Y., T. Mizuno, Y. Sasai, M. Kishi, H. Takeda, C.-H. Kim, M. Hibi and T. Hirano. A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Genes & Development, 12: 2345-2353, 1998.(Abstract)(PubMed) (Full Text in G & D) (研究課題)
160) Matsumura, I., K. Nakajima, H. Wakao, S. Hattori, K. Hashimoto, H. Sugahara, T. Kato, H. Miyazaki, T. Hirano, and Y. Kanakura. Involvement of prolonged Ras activation in thrombopoietin-induced megakaryocytic differentiation of a human factor-dependent hematopoietic cell line. Mol. Cell. Biol. 18:4282-4290,1998. (PubMed)
159) Takahashi-Tezuka*, M., Y. Yoshida*, T. Fukada, T. Yamaguchi, Y. Yamanaka, K. Nakajima, M. Hibi, and T. Hirano. Gab1 acts as an adaptor molecule linking a cytokine receptor gp130 to ERK MAP kinase. Mol. Cell. Biol. 18:4109-4117, 1998. (equal contribution of the first two authors*) (PubMed)(Full Text in MCB)
158) Ichiba, M., K. Nakajima, Y. Yamanaka, N. Kiuchi and T. Hirano Autoregulation of the Stat3 gene through cooperation with a CRE site binding protein. J. Biol. Chem. 273:6132-6138, 1998 (PubMed)
Review-57) Hibi, M., and T. Hirano. Signal transduction through cytokine receptors. Intern. Rev. Immunol., 17, 75-102, 1998.
Review-56) Hirano, T. Interleukin 6. The Cytokine Handbook, 3rd edition, edited by A. W. Thomson, Academic Press, pp197-228, 1998.
Review-55) Hirano, T. Interleukin 6 and its receptor: Ten years later. Intern. Rev. Immunol., 16:249-284, 1998 (Full Text)(PubMed)
1997
157) Kim, C.-H., Y.-K. Bae, Y. Yamanaka, S. Yamashita, T. Shimizu, R. Fujii, H.-C. Park, S.-Y. Yeo, T.-L. Huh, M. Hibi, and T. Hirano. Overexpression of neurogenin induces extopic expression of HuC in zebrafish. Neuroscience Letters 239:113-116, 1997.(PubMed)
156) Narimatsu, M., K. Nakajima, M. Ichiba, M., and T. Hirano. Association of Stat3-dependent transcriptional activation of p19INK4D with the IL-6-induced growth arrest. Biochem. Biophys. Res. Comm. 238: 764-768, 1997. (PubMed)
155) Sekimoto, T., N. Imamoto, K. Nakajima, T. Hirano, and Y. Yoneda. Extracellular signal-dependent nuclear import of stat1 is mediated by nuclear pore-targeting complex formetion with (Via) NPI-1, not Rch1. EMBO J. 16: 7067-7077, 1997. (Abstract)(PubMed)
154) Amato, S. F., K. Nakajima, T. Hirano and T. C. Chiles. Transcriptional regulation of the junB gene in B lymphocytes : Role of protein kinase A and a membrane immunoglobulin-regulated protein phosphatase. J. Immunol. 159:4676-4685, 1997. (PubMed)
153) Shimozaki, K., K. Nakajima, T. Hirano, and S. Nagata. Involvement of STAT3 in the granulocyte colony stimulating factor-induced differentiation of myeloid cells. J. Biol. Chem. 272: 25184-25189, 1997. (PubMed)
152)Ihara, S., K. Nakajima, T. Fukada, M. Hibi, S. Nagata, T. Hirano, and Y. Fukui. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. EMBO J. 16: 5345-5352, 1997(Abstract).(PubMed)(EMBO J)
151) Takahashi-Tezuka, M., M. Hibi, Y. Fujitani, T. Fukada, T. Yamaguchi, and T. Hirano. Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK. Oncogene, 14: 2273-2282, 1997 (Abstract)(PubMed)
150)Fujitani, Y., M. Hibi, T. Fukada, M. Takahashi-Tezuka, H. Yoshida, T. Yamaguchi, K. Sugiyama, Y. Yamanaka, K. Nakajima, and T. Hirano. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene, 14: 751-761, 1997. (Abstract)(PubMed)
Review-54) Hirano, T., K. Nakajima, and M. Hibi. Signaling mechanisms through gp130: a model of the cytokine system. Cytokine & Growth Factor Reviews, 8: 241-252, 1997 (Full Text) (PubMed) (CrossReference)
Review-53) Ishihara, K., Okuyama, Y., Lee, B.OK, Itoh, M., Nishikawa, K., and Hirano, T. Structure, expression, and function of BST-1: its identity with Mo5., in Leucocyte typing VI, 1086-1089, 1997 (FullText)
1996
149) Muraoka, O., H. Tanaka, M. Itoh, K. Ishihara and T. Hirano. Genomic structure of human BST-1. Immunology Letters, 54:1-4, 1996.(PubMed)
148) Fukada, T., M. Hibi, Y. Yamanaka, M. Takahashi-Tezuka,
Y. Fujitani, T. Yamaguchi, K. Nakajima, and T. Hirano. Two signals
are necessary for cell proliferation induced by a cytokine receptor
gp130: involvement of STAT3 in anti-apoptosis. Immunity 5:
449-460, 1996. (Abstract)
(PubMed)(Immunity
on line for Full TEXT)
147) Moffatt, S., N. Tanaka, K. Tada, M. Nose, M. Nakamura, O. Muraoka, T. Hirano, and K. Sugamura. A cytotoxic non-structural protein, NS1, of human parvovirus B19 induces activation of interleukin 6 (IL-6) gene expression. J. Virol. 70:8485-8491, 1996.(PubMed)
146) Okuyama, Y., K. Ishihara, N. Kimura, Y. Hirata, K. Sato, M. Itho, B. O. Lee, and T. Hirano. Human BST-1 expressed on myeloid cells functions as a receptor molecule. Biochem. Biophys. Res. Comm. 228:838-845, 1996. (PubMed)
145) Sekimoto, T., K. Nakajima, T. Tachibana, T. Hirano and Y. Yoneda. Interferon-g-dependent nuclear import of stat1 is mediated by the GTPase activity of Ran/TC4. J. Biol. Chemistry 241:31017-31020, 1996.(PubMed)
144) Amato, S. F., K. Nakajima., T. Hirano., and T. C. Chiles. Transcriptional regulation of the junB promoter in mature B lymphocytes. J. Immunol. 157:146-155, 1996.(PubMed)
143) Ishihara, K., Y. Kobune, Y. Okuyama, M. Itoh, B.O. Lee, O. Muraoka, and T. Hirano. Stage-specific expression of mouse BST-1/BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor. Int. Immunol. 8: 1395-1404, 1996. (Abstract)(PubMed)
142) Kajimoto, Y., J.-I. Miyagawa, K. Ishihara, Y. Okuyama, Y. Fujitani, M. Itoh, H. Yoshida, T. Kaisho, T. Matsuoka, H. Watada, T. Hanafusa, Y. Yamasaki, T. Kameda, Y. Matsuzawa, and T. Hirano. Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. Biochem. Biophys. Res. Comm. 219: 941-946, 1996.(PubMed)
141) Nakajima, K., Y. Yamanaka, K. Nakae, H. Kojima, N. Kiuchi, M. Ichiba, T. Kitaoka, T. Fukada, M. Hibi and T. Hirano. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J. 15:3651-3658, 1996. (Abstract)(PubMed)
140) Yamanaka, Y., K. Nakajima, T. Fukada, M. Hibi, and T. Hirano. Differentiation and growth arrest signals generate through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO J. 15:1557-1565, 1996. (Abstract) (PubMed)
139) Kojima, H., K. Nakajima, and T. Hirano. IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein(s). Oncogene 12: 547-554, 1996. (Abstract)(PubMed)
138) Lee, B. O., K. Ishihara, K. Denno, Y. Kobune, M. Itoh, O. Muraoka, T. Kaisho, T. Sasaki, T. Ochi, and T. Hirano. Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis. Arthritis Rheum. 39: 629-637, 1996. (Abstract)(PubMed)
Review-52) Hibi, M., Nakajima, K., Hirano, T. IL-6 cytokine family and signal transduction: a model of the cytokine system. J. Mol. Med. 74:1-12, 1996.(Abstract)(PubMed)
1995
137) Sanc斬u, J., T. Kaisho, T. Hirano, and J. Wietzerbin. Triggering of the human interleukin-6 gene by interferon-g and tumor necrosis factor-a in monocytic cells involves cooperation between Interferon Regulatory Factor-1, NFkB, and Sp1 transcription factors. J. Biol. Chem. 270: 27920-27931, 1995.
136) Nakae, K., K. Nakajima, J. Inazawa, T. Kitaoka, and T. Hirano. ERM, a PEA3 subfamily of Ets transcription factors, can cooperate with c-Jun. J. Biol. Chem. 270: 23795-23800, 1995.
135) Clark, E.A., K.H. Grabstein, A.M. Gown, M. Skelly, T. Kaisho, T. Hirano, and G. Shu. Activation of B lymphocyte maturation by a human follicular dendritic cell line, FDC-1. J. Immunol. 155: 545-555, 1995.
134) Matsuda, T., T. Fukada, M. Takahashi-Tezuka, Y. Okuyama, Y. Fujitani, Y. Hanazono, H. Hirai, and T. Hirano. Activation of Fes tyrosine kinase by gp130, an Interleukin-6 family cytokine signal transducer, and their association. J. Biol. Chem. 270:11037-11039, 1995.
133) Ishikawa, J., T. Kaisho, H. Tomizawa, B.O. Lee, Y. Kobune, J. Inazawa, K. Oritani, M. Itoh, T. Ochi, K. Ishihara, and T. Hirano. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics, 26: 527-534, 1995.
132) Matsuda, T., M. Takahashi-Tezuka, T. Fukada, Y. Okuyama, Y. Fujitani, S. Tsukada, H. Mano, H. Hirai, O.N. Witte, and T. Hirano. Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the IL-6 family of cytokines. Blood, 85: 627-633,1995.
Review-51) Nakajima, K., T. Matsuda, Y. Fujitani, H. Kojima, Y. Yamanaka, K. Nakae, T. Takeda and T. Hirano. Signal transduction through IL-6 receptor: involvement of multiple protein kinases, Stat factors and a novel H-7-sensitive pathway. Ann. New York Acad. Sci. 762: 55-70, 1995.
1994
131) Hirata, Y., N. Kimura, K. Sato, Y. Ohsugi, S. Takasawa, H.
Okamoto, J. Ishikawa, T. Kaisho, K. Ishihara and T. Hirano. ADP
ribosyl cyclase activity of a novel bone marrow stromal cell surface
molecule, BST-1. FEBS Letters 356: 244-248, 1994.
(Abstract)
130) Itoh, M., K. Ishihara, H. Tomizawa, H. Tanaka, Y. Kobune, J.
Ishikawa,. T. Kaisho and T. Hirano. Molecular cloning of murine BST-1
having homology with CD38 and Aplysia ADP-ribosyl cyclase.
Biochem. Biophys. Res. Comm., 203: 1309-1317, 1994.
(Abstract)
129) Takeda, T., K. Nakajima, H. Kojima and T. Hirano. E1A repression
of IL-6-induced gene activation by blocking the assembly of IL-6
response element binding complexes. J. Immunol. 153:
4573-4582, 1994. (Abstract)
128) Fujitani, Y., K. Nakajima, H. Kojima, K. Nakae, T. Takeda, and
T. Hirano. Transcriptional activation of the IL-6 response element in
the junB promoter is mediated by multiple stat family proteins.
Biochem. Biophys. Res. Comm. 202: 1181-1187, 1994.
(Abstract)
127) Matsuda, T., and T. Hirano. Establishment of the ELISA for
murine soluble gp130, a signal transducer for the IL-6 family
cytokine and its detection in the ascitic fluids of tumor-bearing
mice. Biochem. Biophys. Res. Comm. 202: 637-642, 1994.
126) Matsuda, T., and T. Hirano. Association of p72 tyrosine kinase
with Stat factors and its activation by IL-3, IL-6 and G-CSF.
Blood 83: 3457-3461, 1994.
125) Matsuda, T., Y. Yamanaka, and T. Hirano.
Interleukin-6-induced tyrosine phosphorylation of multiple proteins
in murine hematopoietic lineage cells. Biochem. Biophys. Res.
Comm. 200: 821-828, 1994.
124) Kaisho, T., J. Ishikawa, K. Oritani, J. Inazawa, H. Tomizawa, O.
Muraoka, T. Ochi, and T. Hirano. BST-1, a surface molecule of bone
marrow stromal cell lines that facilitates pre-B cell growth.
Proc. Natl. Acad. Sci. USA 91: 5325-5329, 1994.
(Abstract)
Review-50) Hirano, T., T.
Matsuda, and K. Nakajima. Signal transduction through gp130 that is
shared among the receptors for the interleukin 6 related cytokine
subfamily. Stem Cells, 12: 262-277,
1994.(PubMed)
Review-49) Hirano, T. Interleukin
6 transgenic mouse: A model of chronic inflammatory proliferative
disease. Overexpression and knockout of cytokines in transgenic
mice. edited by C. O. Jacob. Academic Press pp73-84, 1994.
Review-48) Hirano, T. Chapter 8,
Interleukin 6. The Cytokine Handbook, 2nd edition, edited by
A. W. Thomson, Academic Press, pp145-168, 1994.
Review-47) Nakajima, K., T.
Takeda, Y. Fujitani, K. Nakae, H. Kojima and T. Hirano. Interleukin 6
receptor-mediated signal transduction pathways. Gann Monograph on
Cancer Research 42: 37-49, 1994.
Review-46) Matsuda, T., T.
Nakajima, T. Kaisho, K. Nakajima and T. Hirano. Interleukin 6
receptor and signal transduction. Advances in Cell and Molecular
Biology of Membranes and Organelles. 3: 65-92, 1994.
1993-1976（partial list）
122) Muraoka, O., T. Kaisho, M. Tanabe, and T. Hirano.
Transcriptional activation of the interleukin 6 gene by HTLV-1 p40tax
through an NF-kB-like binding site. Immunol. Letters, 37:
159-165, 1993.
121) Nakajima, K., T. Kusafuka, T. Takeda, Y. Fujitani, K.
Nakae and T. Hirano. Identification of a novel interleukin 6
responsive element containing an Ets-binding site and a CRE-like site
in the junB promoter. Mol. Cell. Biol. 13: 3027-3041, 1993.
(Abstract)
117) Kaisho, T., K. Oritani, J. Ishikawa, M. Tanabe, O. Muraoka,
T. Ochi, and T. Hirano. Human bone marrow stromal cell lines from
myeloma and rheumatoid arthritis which can support murine preB cell
growth. J. Immunol. 149: 4088-4095,
1992.(PubMed)
116) Oritani, K., T. Kaisho, K. Nakajima and T. Hirano. Retinoic acid
inhibits interleukin 6-induced macrophage differentiation and
apoptosis in a murine hematopoietic cell line, Y6. Blood 80:
2298-2305, 1992.
113) Suematsu, S., T. Matsusaka, T. Matsuda,
S. Ohno, J. Miyazaki, K. Yamamura, T. Hirano, and T. Kishimoto.
Generation of transplantable plasmacytomas with t(12;15) in IL-6
transgenic mice. Proc. Natl. Acad. Sci. USA 89:232-235,
1992.(Abstract)
98) Hibi, M., M. Murakami, M. Sito, T. Hirano, T. Taga and T.
Kishimoto. Molecular cloning and expression of an IL-6 signal
transducer, gp130. Cell 63:1149-1157,
1990.(PubMed)
91) Sugita, T., T. Totsuka, M. Saito, K. Yamasaki, T. Taga, T.
Hirano, and T. Kishimoto. Functional murine IL-6 receptor with the
intracisternal A-particle gene product at its cytoplasmic domain: Its
possible role in plasmacytomagenesis. J. Exp. Med.
171:2001-2009, 1990.
77) Suematsu, S., T. Matsuda, K. Aozasa, S. Akira, N. Nakano, S. Ohno, J. Miyazaki, K. Yamamura, T. Hirano, T. Kishimoto. IgG1 plasmacytosis in interleukin 6 transgenic mice. Proc. Natl. Acad. Sci. USA. 86:7547-7551, 1989.(Abstract)
75) Yoshizaki, K., T. Matsuda, N. Nishimoto, T. Kuritani, L. Taeho, K. Aozasa, T. Nakahata, H. Kawai, H. Tagoh, T. Komori, S. Kishimoto, T. Hirano, and T. Kishimoto. Pathological significance of interleukin 6 ( IL-6/BSF-2 ) in Castleman's disease. Blood, 74:1360-1367, 1989.
73) Taga, T., M. Hibi, Y. Hirata, K. Yamasaki, K. Yasukawa, T. Matsuda, T. Hirano, and T. Kishimoto. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58:573-581, 1989.(PubMed)
52) Yamasaki, K., T. Taga, Y. Hirata, H. Yawata, Y. Kawanishi, B. Seed, T. Taniguchi, T. Hirano, and T. Kishimoto. Cloning and expression of human interleukin 6 ( BSF-2/IFNb2 ) receptor. Science 241:825-828, 1988.(PubMed)
50) Satoh, T., S. Nakamura, T. Taga, T. Matsuda, T. Hirano, T. Kishimoto, and Y. Kaziro. Induction of neural differentiation in PC12 cells by B cell stimulatory factor 2/interleukin 6. Mol. Cell. Biol. 8:3546-3549, 1988.(Abstract)(PubMed)
49) Miyaura, C., K. Onozaki, Y. Akiyama, T. Taniyama, T. Hirano, T. Kishimoto and T. Suda. Recombinant human interleukin 6 ( B-cell stimulatory factor 2 ) is a potent inducer of differentiation of mouse myeloid leukemia cells ( M1 ). FEBS Lett. 234:17-21, 1988.(Abstract)
47) Hirano, T., T. Matsuda, M. Turner, K. Sato, G. Buchan, B. Tang, N. Miyasaka, M. Shimizu, R. Maini, M. Feldmann, and T. Kishimoto. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18:1797-1801, 1988.(Abstract)
46) Matsuda, T., T. Hirano, and T. Kishimoto. Establishment of interleukin 6 (IL-6)/B cell stimulatory factor 2 (BSF-2)-dependent cell line and preparation of anti-IL-6/BSF-2 monoclonal antibodies. Eur. J. Immunol. 18:951-956, 1988.
43) Kawano, M., T. Hirano, T. Matsuda, T. Taga, Y. Horii, K. Iwato, H. Asaoku, B. Tang, O. Tanabe, H. Tanaka, A. Kuramoto, and T. Kishimoto. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332:83-85, 1988.(Abstract)(PubMed)
37) Muraguchi, A., T. Hirano, B. Tang, T. Matsuda, Y. Horii, K.
Nakajima, and T. Kishimoto. The essential role of B cell stimulatory
factor 2 ( BSF-2/IL-6 ) for the terminal differentiation of B cells.
J. Exp. Med. 167:332-344,1988.
36) Hirano, T., T. Matsuda, K. Hosoi, A. Okano, H. Matsui, T.
Kishimoto. Absence of antiviral activity in recombinant B cell
stimulatory factor 2 ( BSF-2 ). Immunol. Lett. 17:41-45,1988.
31) Yasukawa, K., T. Hirano, Y. Watanabe, K. Muratani, T. Matsuda, and T. Kishimoto. Structure and expression of human B cell stimulatory factor 2 ( BSF-2/IL-6 ) gene. EMBO J. 6:2939-2945, 1987.
28) Hirano, T., T. Taga, K. Yasukawa, K. Nakajima, N. Nakano, F. Takatsuki, M. Shimizu, A. Murashima, S. Tsunasawa, F. Sakiyama, and T. Kishimoto. Human B cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc. Natl. Acad. Sci. USA. 84:228-231, 1987.(PubMed) (Anstract)
26) Hirano, T., K. Yasukawa, H. Harada, T. Taga, Y. Watanabe, T. Matsuda, S. Kashiwamura, K. Nakajima, K. Koyama, A. Iwamatu, S. Tsunasawa, F. Sakiyama, H. Matsui, Y. Takahara, T. Taniguchi, and T. Kishimoto. Complementary DNA for a novel human inteleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324:73-76, 1986.(Abstract)(PubMed)
25) Hirano, T., T. Taga, N. Nakano, K. Yasukawa, S. Kashiwamura, K. Shimizu, K. Nakajima, K. H.Pyun, and T. Kishimoto. Purification to homogeneity and characterization of human B cell differentiation factor (BCDF or BSFp-2). Proc. Natl. Acad. Sci. USA. 82:5490-5494, 1985.(Abstract)(PubMed)
19) Hirano, T., T. Teranishi, Bi-Hu Lin, and K. Onoue. Human
helper T cell factor(s). 1984. IV. Demonstration of human late-
acting B cell differentiation factor acting on Staphylococcus aureus
Cowan I-stimulated B cells. J. Immunol. 133:798-802,
1984.(PubMed)
18) Hirano, T., K. Fujimoto, T. Teranishi, N. Nishino, K. Onoue, S.
Maeda, and K. Shimada. Phorbol ester increases the level of
interleukin 2 mRNA in mitogen-stimulated human lymphocytes. J.
Immunol. 132:2165-2167, 1984.
17) Hirano, T., T. Teranishi, and K. Onoue. Human helper T cell
factor(s). III. Characterization of B cell differentiation factor
I(BCDF I). J. Immunol. 132:229-234,
1984.(PubMed)
13) Hirano, T., T. Sudo, T. Teranishi, K. Fujimoto, M. Iizuka, S.
Kobayashi, and K. Onoue. Translation of human interleukin 2 mRNA in
Xenopus laevis oocytes. Microbiol.Immunol. 27:87-94, 1983.
12) Teranishi, T., T. Hirano, N. Arima,
and K. Onoue. Human helper Tcell factor(s)(ThF). II. Induction of IgG
production in B lymphoblastoid cell lines and identification of T
cell replacing factor-(TRF) like factor(s). J. Immunol.
128:1903-1908,
1982.(Abstract)(PubMed)
10) Hirano, T., T. Teranishi, H. Toba,
N. Sakaguchi, T. Fukukawa, and I. Tsuyuguchi. Human helper T cell
factor(s)(ThF). I. Partial purification and characterization. J.
Immunol. 126:517-522,
1981.(PubMed)
9) Hirano, T., O. Teraoka, T. Teranishi, I. Tsuyuguchi, H. Tohda,
and A. Oikawa. Establishment of autoantibody-producing cell lines
from peripheral blood lymphocytes of patients with systemic lupus
erythematosus. Microbiol. Immunol. 24:879-886, 1980.
7) Hirano, T., T. Kishimoto, T. Kuritani, A. Muraguchi, Y. Yamamura,
P. Ralph, and R. A. Good. In vitro immune response of human
lymphocytes. IV. Specific induction of human suppressor T cells by an
antiserum to the T leukemia cell line HSB. J. Immunol.
123:1133-1140, 1979.
4) Hirano, T., T.Kuritani, T. Kishimoto, and Y. Yamamura. In vitro
immune response of human peripheral lymphocytes. I. The mechanism(s)
involved in T cell helper functions in the pokeweed mitogen-induced
differentiation and proliferation of B cells. J. Immunol.
119:1235-1241, 1977.
3) Hirano, T., and A. A. Nordin. Cell-mediated immune response in vitro. II. The mechanism(s) involved in the suppression of the development of cytotoxic lymphocytes. J. Immunol. 117:2226-2232, 1976.
2) Hirano, T., and A. A. Nordin. Age-associated decline in the in
vitro development of cytotoxic lymphocytes in NZB mice. J.
Immunol. 117:1093-1098, 1976.
1) Hirano, T., and A. A. Nordin. Cell-mediated immune response in
vitro. I. The development of suppressor cells and cytotoxic
lymphocytes in mixed lymphocyte cultures. J. Immunol.
116:1115-1122, 1976.
Review-43) Hirano, T.
Interleukin 6 and autoimmunity and plasma cell neoplasias. Res.
Immunol. 143: 759-763, 1992.
Review-38) Hirano, T. The biology
of interleukin 6. Chemical Immunol. 51:153-180, 1992.
Review-37) Hirano, T.
Interleukin-6 and its relation to inflammation and disease.
Clinical Immunol. Immunopathol. 62:S60-S65, 1992.
Review-35) Hirano, T. Interleukin
6(IL-6). Chapeter 8, The Cytokine Handbook, edited by A.
Thomson, Academic Press, pp169-190, 1991.
Review-34) Hirano, T. Interleukin
6 (IL-6) and its receptor: Their role in plasma cell neoplasias.
International Journal of Cell Cloning 9: 166-184, 1991.
Review-33) Hirano, T., S. Akira,
T. Taga, and T. Kishimoto. Biological and clinical aspects of
interleukin 6. Immunology Today, 11: 443-449, 1990.
Review-28) Hirano, T., and T.
Kishimoto. Chapter 14: Interleukin 6. In Handbook of Experimental
Pharmacology vol. 95/I "Peptide Growth Factors and Their
Receptors" edited by M. B. Sporn and A. B. Roberts, Springer-Verlag,
pp633-665, 1990.
Review-20) Kishimoto, T. and T.
Hirano. Chapter 14: B lymphocyte activation, proliferation and
immunoglobulin secretion. Fundamental Immunology, second
edition., editied by W. E. Paul, Raven Press, pp385-411, 1989.
Review-16) Hirano, T., T. Taga,
K. Yamasaki, T. Matsuda, Y. Hirata, H. Yawata, O. Tanabe, S. Akira,
and T. Kishimoto. Molecular cloning of the cDNAs for interleukin-6/B
cell stimulatory factor-2 and its receptor. Annals of New York
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