新学術領域研究「多階層生体機能学 HD Physiology 」
第一回国際シンポジウム
プログラム
開催日時：平成24年（2012年）1月20日（金曜日）・21日（土曜日）
開催場所：〒113-8654 東京都文京区本郷7-3-1
東京大学武田先端知ビル武田ホール
（アクセス）
プログラム（2011年12月26日更新）
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Day 1st (January 20, Fri.)
Opening
13:00-13:10 Opening Remark: Yoshihisa
Kurachi (HD physiology project leader, Osaka
University)
13:10-13:25 Welcome Address: Yoichiro
Matsumoto (Vise-president, University of Tokyo)
Welcome Lecture
13:25-13:55 Ryutaro Himeno (Riken)
“Grand Challenge in Life
Science on K computer”
Session 1
Information Technology Infrastructure for Physiome and
Systems Biology
Special Lectures
Chair: Hiroaki Kitano
14:00-14:50 Hiroaki Kitano (SBI, OIST)
“HD-Physiology Project
Overview”
14:50-15:40 Hans Westerhoff (University of
Manchester) “IT for Future
Medicine: putting the human where he should be”
Coffee Break (15 min)
Chairs: Yoshiyuki Asai & Akira Amano
15:55-16:25 Akira Funahashi (Keio
University) “CellDesigner 4.2:
A Modeling Tool for Biochemical Networks”
16:25-16:55 Yoshiyuki Asai (OIST)
“Open platform PhysioDesigner
for Multilevel Modeling, Simulation and Model
Sharing”
16:55-17:25 Akira Amano (Ritsumeikan
University) “Software Platform
for Complex Tissue/Organ Level Simulation”
Plenary Lecture
Chair: Ryuji Inoue
17:30-18:20 Denis Noble (University of
Oxford) “The IUPS Physiome,
Where Has It Succeeded and Where Should It Go?”
Reception
19:00-21:00 Welcome Reception
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Day 2nd (January 21, Sat.)
Session 2
Systems Biology on Heart
Chairs: Haruo Honjo & Naomasa Makita
9:00- 9:25 Naomasa Makita (Nagasaki
University) “Molecular and
Physiological Basis of Familial Progressive Heart Block
Type-I”
9:25- 9:50 Takeshi Aiba (NCVC)
“Transmural Heterogeneity of
Ventricular Action Potential and Arrhythmias”
9:50-10:15 Masatoshi Yamazaki (Nagoya
University) “Role of the Left
Atrial Anatomy in the Maintenance of 3-Dimensional Scroll
Waves in Acute, Stretch-Related and Cholinergic Atrial
Fibrillation”
10:15-10:40 Kunichika Tsumoto (Osaka
University) “Roles of
Subcellular Sodium Channel Distribution in the Mechanism of
Cardiac Conduction”
10:40-11:05 Takashi Ashihara (Shiga
University of Medical Science) “Mechanisms of Electrogram-Based Catheter
Ablation for Chronic Atrial Fibrillation”
Coffee Break (15 min)
Invited Lectures
Chairs: Kazuo Nakazawa & Takashi Ashihara
11:20-12:00 Blanca Rodriguez (University
of Oxford) “Multiscale
Investigation into Variability in Cardiac Repolarization
and its Implications in Arrhythmogenesis”
12:00-12:40 Edward J Vigmond (University
of Bordeaux 1) “Modelling
Arrhythmogenic Consequences of the Purkinje System”
Commemorative photos
Lunch Break (2 hours)
13:00-14:45 Luncheon Poster Session (by young researchers,
@foyer)
Discussion Core Time
Odd number: 13:00-13:50
Even number: 13:50-14:40
Session 3
Systems Biology on ADME/Toxicokinetics
Invited Lectures
Chairs: Hiroshi Suzuki & Hiroyuki Kusuhara
15:00-15:40 Walfgang Sadee (Ohio State
University) “Regulation of
Gene Expression Profiles Relevant to Drug Efficacy and
Toxicity”
15:40-16:20 Darrell Abernethy (US Food and
Drug Administration, Johns Hopkins University)
“Pharmacological
Mechanism-Based Drug Safety Prediction: Preliminary Effort
for Tyrosine Kinase Inhibitor Cardiotoxicity”
Coffee Break (15 min)
Chairs: Akihiro Hisaka & Fumiyoshi Yamashita
16:35-17:00 Akihiro Hisaka (University of
Tokyo Hospital) “Physiological
Modeling of Gastrointestinal Absorption”
17:00-17:25 Hiroyuki Kusuhara (University
of Tokyo) “Prediction of in
vivo Hepatic Clearance Based on in vitro Data”
17:25-17:50 Toshiya Katsura (Kyoto
University Hospital) “Importance of MATE1 in Renal Excretion and
Tissue Distribution of Cationic Drugs”
17:50-18:15 Fumiyoshi Yamashita (Kyoto
University) “In Silico
Pharmacokinetics: from QSAR to PK Modeling”
18:15-18:40 Hiroshi Suzuki (University of
Tokyo Hospital) “Toxicokinetics/Toxicodynamics Approaches
to Analyze Non-QT Cardiotoxicity of Kinase
Inhibitors”
Closing
18:45-18:55 Closing Remark