新学術領域研究「多階層生体機能学 HD Physiology」
第二回国際シンポジウム
プログラム
開催日時：平成25年（2013年）6月28日（金曜日）・29日（土曜日）
開催場所：〒100-0005 東京都千代田区丸の内2-1-1 明治安田生命ビル
丸の内 My Plaza Hall
（アクセス）
プログラム（確定）（2013年6月12日更新）
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Day 1st: Friday June
28, 2013
9:15-10:00 Registration
10:00-10:10 Opening Remark: Yoshihisa
Kurachi (HDP Project Director,
Osaka University)
10:10-10:20 Welcome Address: Himeno
Ryutaro (RIKEN)
I. HD-Physiology
Overview
10:25-11:00 Hiroaki
Kitano (HDP, The Systems Biology
Institute, OIST) “HD-Physiology
Project -A Japanese Flagship Physiological Modeling
Project-”
II. The
Interdisciplinary Researches in Pushing the Integrative
Life Science Field
1.Systems Biology Platform, Software &
Tools
Chairs: Yoshiyuki Asai & Akira Funahashi
11:00-11:20 Samik
Ghosh (The Systems Biology
Institute) “Garuda:
An Open, Community Platform for Biomedical
Research”
11:20-11:40 Akira
Funahashi (HDP, Keio University)
“CellDesigner
4.3: A Modeling Tool for Biochemical
Networks”
11:40-12:00 Yoshiyuki
Asai (HDP, OIST)
“PhysioDesigner
and Flint: Modeling and Simulation Tools for Multilevel
Physiological Systems”
12:00-13:10 Lunch Break
2. Quantitative
Biology
Chairs: Kazuhiro Aoki & Noriko Hiroi
13:10-13:30 Kazuhiro
Aoki (HDP, Kyoto University)
“Quantitative
Measurement of In Vivo Dissociation Constant with
Fluorescence Cross-Correlation
Spectroscopy”
13:30-13:50 Taichiro
Tomida (University of Tokyo)
“How Does
MAPK Signal Code Environment? : Imaging of Kinase Activity
in C.elegans”
13:50-14:10 Philip
Bittihn (Max Planck Institute)
“The Role
of Cardiac Structural Heterogeneity during Electric-Field
Stimulation”
14:10-14:30 Urs
Frey (RIKEN QBiC)
“CMOS-Based
Microelectrode Arrays for High-Resolution Electrophysiology
of the Retina”
Special
Lecture
Chair: Hiroyuki Kagechika
14:30-15:05 Michiyuki
Matsuda (Kyoto University)
“FRET
Biosensors as the Tools to Understand the Heterogeneity of
Glioma Cells in a Quantitative Manner”
15:05-15:20 Break
3.Challenge of
Genome- and Protein-Informatics
Chairs: Kengo Kinoshita & Akira Amano
15:20-15:45 Masao
Nagasaki (Tohoku University)
“Genome
Explosion and its Data Management and Bioinformatics on
Supercomputer: the Prospective Genome Chort Study in
Japan”
15:45-16:10 Haruki
Nakamura (Osaka University)
“Prediction
of Protein-Protein Interactions”
Special
Lecture
16:10-16:45 Ryutaro
Himeno (RIKEN)
“Development
of a High Performance Software Package in Life Science for
K Computer and its Applied Results as a Grand
Challenge”
16:45-16:55 Break
Plenary
Lecture
Chair: Ryuji Inoue
16:55-17:30 Toshio
Yanagida (Osaka University, RIKEN
QBiC, NICT CiNet) “Design of
New Measurement and Analysis Techniques to Study Complex
Biological Systems”
4.Systems
Pharmacology
Chairs: Hiroshi Suzuki & Shigehiro Ohdo
17:30-17:55 Donald
Mager (University at Buffalo
SUNY) “Translational
Systems Pharmacology Modeling of Anti-CD20-Based
Combinatorial Chemotherapeutic Regimens”
17:55-18:20 Hiroshi
Suzuki (HDP, University of Tokyo
Hospital) “Systems
Pharmacological Approaches to Analyze TKI
Toxicity”
Special
Lecture
18:20-18:45 Darrell
Abernethy (US Food and Drug
Administration) “A Systems
Approach to Characterize and Predict Tyrosine Kinase
Inhibitor-Induced Cardiotoxicity”
19:30-21:30 Reception at the Hotel Grand Arc Hanzomon
Day 2nd: Saturday June 29, 2013
9:00-9:30 Registration
9:30-9:50: Speech: Kiyoshi
Kurokawa (National Graduate
Institute for Policy Studies)
III. HD Physiology
I. Logics for Integration of Molecular and Cellular
Function
1.Transportsome
Chairs: Yoshikatsu Kanai & Hiroyuki Kusuhara
9:55-10:15 Yoshikatsu
Kanai (Osaka University) “
“Transportsome”,
the Multi-Molecular Assemblies for Transport-Transport and
Transport-Metabolism Couplings”
10:15-10:35 Yasuo
Mori (Kyoto University)
“Receptor
Signaling Integration by TRP
Channelsomes”
Special
Lecture
10:35-11:10 Ernest
Wright (University of California
Los Angeles) “Human
Biology of Active Glucose Transport”
11:10-11:25 Break
2.Spatio-temporal
integration of intracellular signal
transduction
Chairs: Ryuji Inoue & Satomi Adachi-Akahane
Special
Lecture
11:25-11:50 Dermot
Cooper (University of Cambridge)
“Calcium-Sensitive
Adenylyl Cyclases – Key Integrators of cAMP- and
Ca2+-Signaling”
11:50-12:10 Yoshihiro
Ishikawa (HDP, Yokohama City
University) “Regulation
of Cardiac Function by cAMP Signal”
12:10-12:30 Ayako
Takeuchi (HDP, Kyoto University)
“Contribution
of Mitochondrial Na+-Ca2+ Exchanger, NCLX, in Making the
Cardiac Rhythmicity. A Combination Study of Experiments and
Simulations”
12:30-12:50 Asuka
Hatano (University of Tokyo)
“A 3D
Integrated Model of Cardiomyocytes Revealed the Importance
of Intracellular Structure for the Maintenance of
Contractile Function”
12:50-13:00 Group Photo
13:05-13:50 Lunch Break
13:50-14:35 Poster Session
IV. HD Physiology
II. Logics for Integration of Cellular Function and Tissue
Organ Function
1.High Definition Physiology in the Heart, from Ion Channel
to Organ
Chairs: Mark R Boyett & Haruo Honjo
Special
Lecture
14:40-15:10 Mark R
Boyett (University of Manchester)
“High
Definition Mapping of the Cardiac Conduction
System”
15:10-15:30 Shin
Inada (HDP, National Cerebral
and Cardiovascular Center) “Multi-Scale
Simulation Studies of Excitation Conduction from the
Sinoatrial Node to the Ventricles in the
Heart”
15:30-15:50 Takeshi
Aiba (HDP, National Cerebral
and Cardiovascular Center) “Biophysical
Properties of Na Channel in the S5-S6 High Risk LQT3
Mutations of the Long QT Syndrome”
15:50-16:10 Yukiomi
Tsuji (Nagasaki University)
“Ventricular
Fibrillation Storm and Ca2+/Calmodulin-Dependent Protein
Kinase II”
16:10-16:25 Break
Special
Lecture
Chair: Hiroshi Suzuki
16:25-16:55 Hiroshi
Tanaka (Tokyo Medical and Dental
University) “Systems
Molecular Medicine for Cancer Metastasis and Drug
Discovery”
Plenary
Lecture
Chair: Hiroaki Kitano
16:55-17:30 Adriano
M. Henney (The Virtual Liver
Network, University of Heidelberg) “The
Virtual Liver: A Multidisciplinary, Multilevel Challenge
for Systems Biology”
17:30-17:40 Closing Remarks: Hiroaki
Kitano (HDP Project Co-Director,
The Systems Biology Institute, OIST)