オートファジーグループ：論文の紹介
GIT2によるRac1抑制とポドサイト保護機構 (解説)
J Am Soc Nephrol . 2025 Feb 28. PMID:40019803 DOI: 10.1681/ASN.0000000614.
Rac1 Suppression by the Focal Adhesion Protein GIT ArfGAP2 and Podocyte Protection.
Naoyuki Shimada, Jun Matsuda, Kana Asano-Matsuda, Maho Tokuchi, Lamine Aoudjit, Agnieszka Masztalerz, Serge Lemay, Tomoko Takano, Yoshitaka Isaka
加齢による近位尿細管のTFEB活性低下は、全身の脂質代謝を悪化させAPOA4アミロイドーシスの原因となる (解説)
JCI Insight. 2024 Dec 19:e184451. PMID:39699959 DOI: 10.1172/jci.insight.184451.
Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis.
Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Hideaki Kawai, Isao Matsui, Tadashi Yamamuro, Ryuya Edahiro, Seiji Takashima, Akira Takasawa, Yukinori Okada, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka
SGLT2阻害薬エンパグリフロジンは近位尿細管へのアルブミン曝露を減らしオートファジー停滞を解消することで腎保護に働く (解説)
Autophagy. 2024 Oct 14:1-15. PMID:39385699 DOI: 10.1080/15548627.2024.2410621
Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules.
Sho Matsui, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba-Hamano, Jun Matsuda, Satoshi Minami, Shinsuke Sakai, Hiroaki Yonishi, Jun Nakamura, Shihomi Maeda, Ayumi Matsumoto, Isao Matsui, Motoko Yanagita, Yoshitaka Isaka
MondoAは急性腎障害に対抗し慢性腎臓病への進展を抑制する (解説)
J Am Soc Nephrol. 2024 May 31. PMID:38819935 DOI: 10.1681/ASN.0000000000000414
MondoA and AKI and AKI-to-CKD Transition.
Shihomi Maeda, Shinsuke Sakai, Yoshitsugu Takabatake, Takeshi Yamamoto, Satoshi Minami, Jun Nakamura, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Sho Matsui, Atsuhiro Imai, Ryuya Edahiro, Hitomi Yamamoto-Imoto, Isao Matsui, Seiji Takashima, Ryoichi Imamura, Norio Nonomura, Motoko Yanagita, Yukinori Okada, Andrea Ballabio, Shuhei Nakamura, Tamotsu Yoshimori, Yoshitaka Isaka
FGF21とオートファジーは協調的に加齢や肥満による腎臓病進展に対抗する (解説)
Autophagy. 2023 Sep 18. PMID:37722816 DOI: 10.1080/15548627.2023.2259282
FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity.
Satoshi Minami, Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Jun Nakamura, Shihomi Maeda, Sho Matsui, Isao Matsui, Yoshitaka Isaka
TFEBを介したリソソーマルエクソサイトーシスは高脂肪食による腎脂肪毒性を軽減する (解説)
JCI insight. 2023 Jan 17; e162498 PMID:36649084 DOI: 10.1172/jci.insight.162498
TFEB-Mediated Lysosomal Exocytosis Alleviates High Fat Diet–Induced Lipotoxicity in the Kidney.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y.
尿中マルベリー小体は、ファブリー病の腎病変の早期診断および酵素補充療法の効果判定のバイオマーカーとして有用である (解説)
Nephrol Dial Transplant. 2020 Dec 24:gfaa298 PMID:33367839
Urinary mulberry bodies as a potential biomarker for early diagnosis and efficacy assessment of enzyme replacement therapy in Fabry nephropathy.
Yonishi H, Namba-Hamano T, Hamano T, Hotta M, Nakamura J, Sakai S, Minami S, Yamamoto T, Takahashi A, Kobayashi W, Maeda I, Hidaka Y, Takabatake Y, Sakai N, Isaka Y.
シュウ酸カルシウム腎症における傷害リソソームの修復には脂質化LC3を介したTFEBの活性化が必須である (解説)
Nat Cell Biol. 2020 Oct;22(10):1252-1263 PMID:32989250
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Nakamura S, Shigeyama S, Minami S, Shima T, Akayama S, Matsuda T, Esposito A, Napolitano G, Kuma A, Namba-Hamano T, Nakamura J, Yamamoto K, Sasai M, Tokumura A, Miyamoto M, Oe Y, Fujita T, Terawaki S, Takahashi A, Hamasaki M, Yamamoto M, Okada Y, Komatsu M, Nagai T, Takabatake Y, Xu H, Isaka Y, Ballabio A, Yoshimori T.
オートファジーは高リン負荷による腎尿細管ミトコンドリア傷害に対抗する (解説)
Biochemical and Biophysical Research Communications, 524(3), 636–642 Apr 2020. PMID:32029271
Autophagy protects kidney from phosphate-induced mitochondrial injury.
Fujimura R, Yamamoto T, Takabatake Y, Takahashi A, Namba-Hamano T, Minami S, Sakai S, Matsuda J, Hesaka A, Yonishi H, Nakamura J, Matsui I, Matsusaka T, Niimura F, Yanagita M, Isaka Y.
エイコサペンタエン酸はオートファジーフラックスを回復することで腎脂肪毒性を軽減する (解説)
Autophagy. 2020 Jun 16. PMID:32546086
Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux.
Yamamoto T, Takabatake Y, Minami S, Sakai S, Fujimura R, Takahashi A, Namba-Hamano T, Matsuda J, Kimura T, Matsui I, Kaimori JY, Takeda H, Takahashi M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Isaka Y.
近位尿細管におけるRubiconノックアウトマウスはメタボリックシンドロームを呈する (解説)
Autophagy. 2020 Jan 16. PMID:31944172
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y.
近位尿細管におけるオートファジー活性は１型および２型糖尿病で異なる (解説)
J Am Soc Nephrol. 2019 Apr 30. PMID:31040190
Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes.
Sakai S, Yamamoto T, Takabatake Y, Takahashi A, Namba-Hamano T, Minami S, Fujimura R, Yonishi H, Matsuda J, Hesaka A, Matsui I, Matsusaka T, Niimura F, Yanagita M, Isaka Y.
内皮細胞オートファジーは抗酸化作用を介して腎糸球体係蹄の統合性維持に寄与する (解説)
Autophagy. 2018;14(1):53-65. PMID:29130363
Antioxidant role of autophagy in maintaining the integrity of glomerular capillaries.
Matsuda J, Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Minami S, Sakai S, Fujimura R, Kaimori JY, Matsui I, Hamano T, Fukushima Y, Matsui K, Soga T, Isaka Y.
オートファジーによる脂肪滴分解（リポファジー）は、近位尿細管において飢餓時のエネルギー恒常性を維持する (解説)
Autophagy. 2017 Aug 16:1-19. PMID:28813167
Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation.
Minami S, Yamamoto T, Takabatake Y, Takahashi A, Namba T, Matsuda J, Kimura T, Kaimori JY, Matsui I, Hamano T, Takeda H, Takahashi M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Isaka Y.
近位尿細管細胞においてオートファジーはリソソームの合成と機能を促進することによってAGEの分解に寄与する (解説)
Diabetes. 2017 May;66(5):1359-1372. PMID:28246295
Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules.
Takahashi A, Takabatake Y, Kimura T, Maejima I, Namba T, Yamamoto T, Matsuda J, Minami S, Kaimori JY, Matsui I, Matsusaka T, Niimura F, Yoshimori T, Isaka Y.
オートファジーフラックス障害とミトコンドリア機能低下は近位尿細管における脂肪毒性に寄与する (解説)
J Am Soc Nephrol. 2017 May;28(5):1534-1551. PMID:27932476
High-Fat Diet-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney.
Yamamoto T, Takabatake Y, Takahashi A, Kimura T, Namba T, Matsuda J, Minami S, Kaimori JY, Matsui I, Matsusaka T, Niimura F, Yanagita M, Isaka Y.
炎症性タンパク質の分泌にはオートファジーが関与する (解説)
EMBO J. 2017 Jan 4;36(1):42-60. PMID 27932448
Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy.
Kimura T, Jia J, Kumar S, Choi SW, Gu Y, Mudd M, Dupont N, Jiang S, Peters R, Farzam F, Jain A, Lidke KA, Adams CM, Johansen T, Deretic V.
慢性腎臓病の予後推定に有効なアミノ酸を発見 (解説)
Sci Rep. 2016 May 18;6:26137. PMID 27188851
Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease.
Kimura T, Hamase K, Miyoshi Y, Yamamoto R, Yasuda K, Mita M, Rakugi H, Hayashi T, Isaka Y.
加齢によるオートファジー活性の変化がミトコンドリア機能低下を介して腎老化を引き起こす (解説)
Autophagy. 2016 May 3;12(5):801-13. PMID 26986194
Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule.
Yamamoto T, Takabatake Y, Kimura T, Takahashi A, Namba T, Matsuda J, Minami S, Kaimori JY, Matsui I, Kitamura H, Matsusaka T, Niimura F, Yanagita M, Isaka Y, Rakugi H.
腎臓におけるオートファジーはミトコンドリアの品質管理を介して代謝性アシドーシスに対して防御的な役割を有する (解説)
J Am Soc Nephrol. 2014 Oct;25(10):2254-66. PMID 24700866
Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis.
Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Matsuda J, Kitamura H, Niimura F, Matsusaka T, Iwatani H, Matsui I, Kaimori J, Kioka H, Isaka Y, Rakugi H.
オートファジーはシスプラチン腎症に対抗する (解説)
Am J Pathol 2012; 180: 517-25, PMID 21493778
Autophagy guards against cisplatin-induced acute kidney injury.
Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H
オートファジーは近位尿細管において加齢ストレスや虚血障害に対抗する (解説)
J Am Soc Nephrol 2011; 22: 902-13, PMID 21493778
Autophagy protects the proximal tubule from degeneration and acute ischemic injury.
Kimura T, Takabatake Y, Takahashi A, Kaimori JY, Matsui I, Namba T, Kitamura H, Niimura F, Matsusaka T, Soga T, Rakugi H, Isaka Y