神経化学研究室

英文論文

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　 題名 著者 誌名 巻（号）：頁-頁, 年
2022 1 Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD Tomoya Taminato, Toshihide Takeuchi*, Morio Ueyama, Kohji Mori, Manabu Ikeda, Hideki Mochizuki, Yoshitaka Nagai* Human Molecular Genetics (in press)
2 Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 Czuppa M, Dhingra A, Zhou Q, Schludi C, König L, Scharf E, Farny D, Dalmia A, Täger J, Castillo-Lizardo M, Katona E, Mori K, Aumer T, Schelter F, Müller M, Carell T, Kalliokoski T, Messinger J, Rizzu P, Heutink P, Edbauer D. Cell Reports 39, 110913, June 7, 2022
3 An Alzheimer's disease pathway uncovered by functional omics: the risk gene CELF1 regulates KLC1 Kikuchi M, Viet J, Nagata K, Sato M, David G, Audic Y, Silverman MA, Yamamoto M, Akatsu H, Hashizume Y, Chiba K, Takeda S, Akamine S, Miyamoto T, Uozumi R, Gotoh S, Mori K, Ikeda M, Paillard L, Morihara T. MedRxiv, Posted March 02, 2022.
4 FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA Fujino Y, Ueyama M, Ishiguro T, Ozawa D, Sugiki T, Ito H, Murata A, Ishiguro A, Gendron TF, Mori K, BioRxiv Posted November 01, 2022.
5 RNA dysmetabolism and repeat associated non-AUG translation in Frontotemporal Lobar Mori K*, Gotoh S, Uozumi R, Miyamoto T, Akamine S, Kawabe Y, Tagami S, Ikeda M JMA Journal　Vol. 6, No. 1, 2023 
6 Biological basis and psychiatric symptoms in frontotemporal dementia Mori K*, Ikeda M Psychiatry and Clinical Neuroscience, 76, 351-360, 2022
2021 1 The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene Mori K, Gotoh S, Yamashita T, Uozumi R, Kawabe Y, Tagami S, Kamp F, Nuscher B, Edbauer D, Haass C, Nagai Y, Ikeda M. J Biol Chem Oct;
297(4):101120,
2021
[Published online
 25 Aug 2021]
2 Repurposing bromocriptine for Aβ metabolism in Alzheimer's disease (REBRAnD) study: Randomised Placebo-Controlled Double-Blind Comparative Trial and Open-Label Extension Trial to Investigate the Safety and Efficacy of Bromocriptine in Alzheimer's Disease with Presenilin 1 (PSEN1) Mutations  Kondo T, Banno H, Okunomiya T, Amino Y, Endo K, Nakakura A, Uozumi R, Kinoshita A, Tada H, Morita S, Ishikawa H, Shindo A, Yasuda K, Taruno Y, Maki T, Suehiro T, Mori K, Ikeda M, Fujita K, Izumi Y, Kanemaru K, Ishii K, Shigenobu K, Kutoku Y, Sunada Y, Kawakatsu S, Shiota S, Watanabe T, Uchikawa O, Takahashi R, Tomimoto H, Inoue H BMJ Open 11(6)
e051443, 2021
2020 1 Successive cleavage of β-amyloid precursor protein by γ-secretase Funamoto S, Tagami S, Okochi M, Morishima-Kawashima M. Seminars in Cell
and
Developmental
Biology,
Sep;105:64-74.
2020 doi:
10.1016/j.semcdb.
2020.04.002.
2 Clinical trials for Alzheimer disease and perspectives Tagami S, Takeda M, Okochi M. Cognition &
Rehabilitation.
Dec;p12-19 Vol.1
2020
3 Poly-Glycine-Alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3 Nihei Y, Mori K, Werner G, Arzberger T, Zhou Q, Khosravi B, Japtok J, Hermann A, Sommacal A, Weber M, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Kamp F, Nuscher B, Edbauer D, Haass C. Acta
Neuropathologica
139(1),
99-118, 2020
　 4 A History of Antidementic Drug Development in Japan Takeda M, Tagami S. Taiwan J of
Psychiatry,
34 p152-161,
2020
2019 1 Efficacy, Safety, and Tolerability of Switching from Oral Cholinesterase Inhibitors to Rivastigmine Transdermal Patch with 1-Step Titration in Patients with Mild to Moderate Alzheimer's Disease: A 24-Week, Open-Label, Multicenter Study in Japan. Ueda K, Katayama S, Arai T, Furuta N, Ikebe S, Ishida Y, Kanaya K, Ouma S, Sakurai H, Sugitani M, Takahashi M, Tanaka T, Tsuno N, Wakutani Y, Shekhawat A, Das Gupta A, Kiyose K, Toriyama K, Nakamura Y.　 Dement Geriatr Cogn Dis Extra.
15;9(2):302-318、
2019　 doi:
10.1159/000501364.
eCollection
2019 May-Aug.
2 Cerebral blood flow and Alzheimer's disease-related biomarkers in cerebrospinal fluid in idiopathic normal pressure hydrocephalus. Azuma S, Kazui H, Kanemoto H, Suzuki Y, Sato S, Suehiro T, Matsumoto T, Yoshiyama K, Kishima H, Shimosegawa E, Tanaka T, Ikeda M. Psychogeriatrics.
19(6):527-538、
2019. doi:
10.1111/psyg.
12435. 
3 Apathy and right caudate perfusion in idiopathic normal pressure hydrocephalus: a case-control study. Kanemoto H, Kazui H, Suehiro T, Kishima H, Suzuki Y, Sato S, Azuma S, Matsumoto T, Yoshiyama K, Shimosegawa E, Tanaka T, Ikeda M. Int J Geriatr
Psychiatry. 34(3):
453-462、2019
doi:10.1002/
gps.5038.
2018 1 Two neuropsychiatric cases seropositive for bornavirus improved by ribavirin  Matsunaga H, Fukumori A, Mori K, Honda T, Uema T, Tomonaga K Japanese Journal
of Infectious
Diseases
71(5):338-342,
2018  
2 Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase Steiner H, Fukumori A, Tagami S, Okochi M Cell Stress. 2018
in press
2017 1  Neural Basis of Apathy in Patients with Amnestic Mild Cognitive Impairment. Kazui H, Takahashi R, Yamamoto Y, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Azuma S, Suehiro T, Shimosegawa E, Ishii K, Tanaka T.  J Alzheimers Dis.2017;55(4):
1403-1416. 
doi: 10.3233/
JAD-160223.
2 Effects of donepezil on sleep disturbances in patients with dementia with Lewy bodies: an open-label study with actigraphy.  Kazui H, Adachi H, Kanemoto H, Yoshiyama K, Wada T, Tokumasu-Nomura K, Tanaka T, Ikeda M.  Psychiat Res. doi:
http://dx.doi.org/
10.1016/
j.psychres.
2017.02.039
3 Semagacestat Is a Pseudo-Inhibitor of γ-Secretase. Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M. Cell Rep. 2017 Oct
3;21(1):
259-273.
doi:10.1016/j.celrep.
2017.09.032.
4 Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene Davidson YS, Flood L, Robinson AC, Nihei Y, Mori K, Rollinson S, Richardson A, Benson BC, Jones M, Snowden JS, Pickering-Brown S, Haass C, Lashley T, Mann DMA Acta
Neuropathologica
Communications
5:31, 2017
5 Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins Zhou Q, Lehmer C, Michaelsen M, Mori K, Alterauge D, Baumjohann D, Schludi MH, Greiling J, Farny D, Flatley A, Feederle R, May S, Schreiber F, Arzberger T, Kuhm C, Klopstock T, Hermann A, Haass C, Edbauer D EMBO Molecular
Medicine 9(5):
687-702, 2017
6 Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA-Schizophrenia consortium. Walton E, (24名中略）Hashimoto R (60名中25番目）（33名中略）Ehrlich S.  Acta Psychiatrica
Scandinavica,
135(5):439-447,
2017
7 Transethnic replication study to assess the association between clozapine-induced agranulocytosis/granulocytopenia and genes at 12p12.2 in a Japanese population. Saito T, Ikeda M, Hashimoto R, Clozapine Pharmacogenomics Consortium of Japan (CPC-J), Iwata N. Biol Psychiatry,
82(1):e9-e10,
2017
8 Microglia-derived neuregulin expression in psychiatric disorders. Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato T, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami S, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T. Brain Behav
Immun, 61:
375-385, 2017
9 Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Guadalupe T, (62名中略)　Hashimoto R,(160名中64番目)（95名中略）Francks C.  Brain Imaging and
Behaviour 11(5):
1497-1514, 2017
10 A Brief Assessment of Intelligence Decline in Schizophrenia as Represented by the Difference between Current and Premorbid IQ. Ohi K, Sumiyoshi C, Fujino H, Yasuda Y, Yamamori H, Fujimoto M, Sumiyoshi T, Hashimoto R. Frontiers in
Psyhiatry
-Psyhopathology.
8:293, 2017
11 Effect of clozapine on DNA methylation in peripheral leukocytes frompatients with treatment-resistant schizophrenia. Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T. Int J Mol Sci,
18(3):632, 2017
12 High-resolution copy number variation analysis of schizophrenia in Japan. Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N. Mol Psychiatry,
22(3):430-440,
2017
13 Novel genetic loci associated with hippocampal volume. Hibar DP, (199名中略)　Hashimoto R,(332名中201番目)（130名中略）Ikram MA. Nat Commun,
18;8:13624,
 2017
14 ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide. Thompson P, (29名中略）Hashimoto R, (71名中31番目）Wright M, Ye J, for the ENIGMA Consortium. NeuroImage, 145
(Pt B):389-408,
 2017
15 The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia: Analysis of 778 subjects. Hashimoto N, Ito Y, Okada N, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Takemura A, Son S, Narita H, Yamamoto M, Tha KK, Katsuki A, Ohi K, Yamashita F, Koike S, Takahashi T, Nemoto K, Fukunaga M, Onitsuka T, Watanabe Y, Yamasue H, Suzuki M, Kasai K, Kusumi I, Hashimoto R, for COCORO. NeuroImage Clin,
17;563-569,
 2017
16 High-speed and scalable whole-brain imaging in rodents and primates. Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H. Neuron,
94:1085-1100,
2017
17 Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia. Isomura S, Hashimoto R, Nakamura M, Yamashita F, Jimbo S, Hirano Y, Yamamori H, Fujimoto M, Yasuda Y, Mears R, Onitsuka T. NPJ Schizophrenia,
3(1):3:1-4,
2017
18 Cardiogenic shock caused by left mid-ventricular obstruction in a patient with anorexia nervosa; A novel cardiac manifestation of refeeding syndrome. Sakamoto Y, Kioka H, Hashimoto R, Takeda S, Ohtani T, Yamaguchi O, Wasa M, Nakatani S, Sakata Y. Nutrition,
35:148-150,
2017
19 Eye movement as a biomarker of schizophrenia:Using an integrated eye movement score Morita K, Miura K, Fujimoto M, Yamamori H, Yasuda Y, Iwase M, Kasai K, Hashimoto R. Psychiatry Clin
Neurosci, 71(2):
104-114, 2017
20 Optimizing Outcomes in Clozapine Rechallenge Following Neutropenia Using Human Leukocyte Antigen Typing: A Case Report. Yamaki N, Hishimoto A, Otsuka I, Sasada T, Boku S, Saito T, Yasuda Y, Yamamori H, Ikeda M, Ikeda M, Sora I, Iwata N, Hashimoto R. Psychiatry Clin
Neurosci, 71(4):
289-290, 2017
21 Estimated cognitive decline in patients with schizophrenia: a multi-center study. Fujino H, Sumiyoshi C, Yasuda Y, Yamamori H, Fujimoto M, Fukunaga M, Miura K, Takebayashi Y, Okada N, Isomura S, Kawano N, Toyomaki A, Kuga H, Isobe M, Oya K, Okahisa Y, Takaki M, Hashimoto N, Kato M, Onitsuka T, Ueno T, Ohnuma T, Kasai K, Ozaki N, Sumiyoshi T, Imura O, Hashimoto R. Psychiatry Clin
Neurosci, 71(5):
294-300, 2017
22 Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine. Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R. Schizophr Res,
181:75-82, 2017
2016 1 Substrate Recruitment of γ-Secretase and Mechanism of Clinical Presenilin Mutations Revealed by Photoaffinity Mapping. Fukumori A. and Steiner H EMBO J.
35(15):1628-43,
2016
2 Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H. EMBO Mol Med.
8(5) 458-65,
2016
3 Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74. Hüttl S, Helfrich F, Mentrup T, Held S, Fukumori A, Steiner H, Saftig P, Fluhrer R, Schröder B. Biochem J.
473(10):1405-22,
 2016
4 Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM). Tsaktanis T, Kremling H, Pavšič M, von Stackelberg R, Mack B, Fukumori A, Steiner H, Vielmuth F, Spindler V, Huang Z, Jakubowski J, Stoecklein NH, Luxenburger E, Lauber K, Lenarčič B, Gires O. J Biol Chem.
291(1):425,
2016
5 Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases. Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C. J Biol Chem.
291(1):318-33,
2016
6 Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition Mori K, Nihei Y, Arzberger T, Zhou Q, Mackenzie I.R., Herrmann A, Hanisch F, German Consortium for Frontotemporal Lobar Degeneration, Bavarian Brain Banking Alliance, Kamp F, Nuscher B, Orozco D, Edbauer D, Haass C EMBO Rep.
17(9):1314-25,
 2016
14 Identification of Small Peptides in Human Cerebrospinal Fluid upon Amyloid-β Degradation N.Mizuta, K.Yanagida, T.Kodama, T.Tomonaga, M.Takami,  H.Oyama,  T.Kudo,  M.Ikeda, M.Takeda,  S.Tagami,  M.Okochi  Neurodegener Dis
2017;17:
103-109
15 Functional connectivity assessed by resting state EEG correlates with cognitive decline of Alzheimer's disease - An eLORETA study-  Hata M, Kazui H, Tanaka T, Ishii R, Leonides C, Pasqual-Marqui RD, Aoki Y, Ikeda S, Kanemooto H, Yoshiyama K, Iwase M,, Takeda M.  Clin Neurophysiol.
127(2):
1269-1278,2016
16 Sleep disturbances are key symptoms of very early stage Alzheimer disease with behavioral and psychological symptoms: a Japan multi-center cross-sectional study (J-BIRD).  Kabeshita Y, Adachi H, Matsushita M, Kanemoto H, Sato S, Suzuki Y, Yoshiyama K, Shimomura T, Yoshida T, Shimizu H, Matsumoto T, Mori T, Kashibayashi T, Tanaka H, Hatada Y, Hashimoto M, Nishio Y, Komori K, Tanaka T, Yokoyama K, Tanimukai S, Ikeda M, Takeda M, Mori E, Kudo T, Kazui H.  Int J Geriatr
Psychiatry. 32(2):
222-230,2016. 
17 Cerebrospinal fluid biomarkers of Alzheimer's disease correlate with electroencephalography parameters assessed by exact Low-Resolution Electromagnetic Tomography (eLORETA).  Hata M, Tanaka T, Kazui H, Ishii R, Canuet L, Pascual-Marqui RD, Aoki Y, Ikeda S, Sato S, Suzuki Y, Kanemoto H, Yoshiyama K, Iwase M. Clin EEG Neurosci.
 2016 Aug 11. pii:
1550059416662119. 
18 Association between high biomarker probability of Alzheimer's disease and improvement of clinical outcomes after shunt surgery in patients with idiopathic normal pressure hydrocephalus.  Kazui H, Kanemoto H, Yoshiyama K, Kishima H, Suzuki Y, Sato S, Suehiro T, Azuma S1), Yoshimine T, Tanaka T.  J Neurol Sci.
369:236-241,
2016.
19 Differences of Behavioral and Psychological Symptoms of Dementia in Disease Severity in Four Major Dementias.  Kazui H, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Hashimoto M, Ikeda M, Tanaka H, Hatada Y, Matsushita M, Nishio Y, Mori E, Tanimukai S, Komori K, Yoshida T, Shimizu H, Matsumoto T, Mori T, Kashibayashi T, Yokoyama K, Shimomura T, Kabeshita Y, Adachi H, Tanaka T.  PLoS One.
11(8):e0161092,
2016
2015 1 Association of CSF tap-related oscillatory activity and shunt outcome in idiopathic normal pressure hydrocephalus.  Ikeda S, Kazui H, Tanaka T, Ishii R, Aoki Y, Hata M, Canuet L, Yoshiyama K, Iwase M, Takeda M.  Psychogeriatrics.
15(3):191-197,
2015.
2 Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus.  Aoki Y, Kazui H, Tanaka T, Ishii R, Wada T, Ikeda S, Hata M, Canuet L, Katsimichas T, Musha T, Matsuzaki H, Imajo K, Yoshida T, Nomura K, Yoshiyama K, Iwase M, Takeda M.   Sci Rep.  5:7775.
doi:
10.1038/srep07775.
 2015.
3 Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment.   Yasuno F, Kazui H, Yamamoto A, Morita N, Kajimoto K, Ihara M, Taguchi A, Matsuoka K, Kosaka J, Tanaka T, Kudo T, Takeda M, Nagatsuka K, Iida H, Kishimoto T.   Neurobiol Aging.
36(6):
2145-52, 2015. 
4 Delayed atrophy in posterior cingulate cortex and apathy after stroke. Matsuoka K, Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Sekiyama A, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K  Int J Geriatr
Psychiatry 30:
 566-572, 2015
5 Fluvoxamine alleviates paclitaxel-induced neurotoxicity.  Tanimukai H, Kudo T Biochem Biophys
Reports  4,
 202-206, 2015
2014 1 Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice T, Chevallier N, Marcha S, Takeda M, Kudo T Cell Death and
Disease  5,
 e1332, 2014
2 In vitro acetylcholinesterase inhibitory activity and the antioxidant properties of Aegle marmelos leaf extract: implications for the treatment of Alzheimer's disease.  Asaduzzaman M, Uddin MJ, Kader MA, Alam AH, Rahman AA, Rashid M, Kato K, Tanaka T, Takeda M, Sadik G.  Psychogeriatrics.
14(1):1-10,
2014.
3 Absolute Quantitation of Low Abundance Plasma APL1β peptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment.

 Sano S, Tagami S, Hashimoto Y, Yoshizawa-Kumagaye K, Tsunemi M, Okochi M, Tomonaga T. J Proteome Res.
13(2):1012-20,
 2014
4 Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population. Miyashita A, Wen Y, Kitamura N, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Furukawa K, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Nishizawa M, Suga M, Kawase Y, Akatsu H, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Yamaguchi H, Akazawa K, Kanazawa I, Ihara Y, Ikeuchi T, Kuwano R. J Alzheimers Dis
41(4):1031-8,
2014
5 Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier. Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS,Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T,Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M. Proc Natl Acad
Sci U S A. 111(7):
2638-43, 2014
2013 1 An observational study of insomnia and nightmare treated with Trazodone in patients with advanced cancer. Tanimukai H, Murai T, Okazaki N, Matsuda Y, Okamoto Y, Kabeshita Y, Ohno Y, Tsuneto S Am J Hosp Palliat
Care 30（4）:
359 - 362, 2013
2 Can gradual dose titration of Ketamine for management of neuropathic pain prevent psychotomimetic effects in patients with advanced cancer? Okamoto Y, Tsuneto S, Tanimukai H, Matsuda Y, Ohno Y, Tsugane M, Uejima E Am J Hosp Palliat
Care 30（5）:
450-454, 2013 
3 Involvement of endoplasmic reticulum stress in tauopathy Sakagami Y, Kudo T, Tanimukai H, Kanayama D, Omi T, Horiguchi K, Okochi M, Imaizumi K, Takeda M Biochem Biophys
Res Commun
430(2):500-4,
2013
4 Paclitaxel induces neurotoxicity through endoplasmic reticulum stress Tanimukai H, Kanayama D, Omi T, Takeda M, Kudo T Biochem Biophys
Res Commun
437(1):151-155,
2013 
5 γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43 Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M


 Cell Rep 3(1):
42-51,2013
6 Understanding the conflicting demands of family caregivers caring for depressed family members Yamashita N, Kuzuoka H, Hirata K, Kudo T  CHI2013:
2637-2646, 2013
7 Inge Grundke-Iqbal, Ph.D. (1937-2012): the Discoverer of the Abnormal Hyperphosphorylation of Tau in Alzheimer's Disease Alonso CA, Ekkard E, Gong CX, Liu F, Tanaka T, Kudo T, Tatebayashi Y, Pei JJ, Wang JZ, Khatoon S, Flory M, Ghetti B, Gozes I, Novak M, Novak M, Robakis NK, Leon M, Iqbal M J Mol Neurosci
DOI　10.1007/
]s12031-012-9925-z,
2013
8 Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice Nakanishi T, Shimazawa M, Sugitani S, Kudo T, Imai S, Inokuchi Y, Tsuruma K, Hara H J Neurochem
125(1):111-124,
2013
9 Two advanced cancer patients in whom escitalopram　was useful for depression Nakajima S,Tanimukai H,Baba M,Amano K, awasaki M,Wakayama H Palliative Care
Research 8(2):
548-553, 2013
10 SORL1 Is Genetically Associated with Late-Onset Alzheimer's Disease in Japanese, Koreans and Caucasians Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I; The Alzheimer Disease Genetics Consortium, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R PLoS One 8(7).
 doi:10.1371/
annotation/
fcb56ea7-
d32a-4e45-818d-
39cef330c731,
2013
2012 1 A Retrospective Chart Review of Terminal Patients with Cancer with Agitation and Their Risk Factors Nagase M, Okamoto Y, Tsuneto S, Tanimukai H, Matsuda Y, Okishiro N, Oono Y, Tsugane M, Takagi T, Uejima E J Palliat Med
15(11):
1185-1190, 2012 
2 Non-pharmacological intervention for dementia patients. Takeda M, Tanaka T, Okochi M, Kazui H Psychiatry Clin
Neurosci 66(1):
1-7,2012
2011 1 Molecular pathology of tauopathy and fronto temporal lobar degeneration:  accumulation and aggregation of tau protein in tauopathies Tanaka T, Sadik G, Yanagi K, Kato K, Takeda M Asian J Psychiatr
4(Suppl.1)
S1-S96, 2011
2 Pharmacogenomics of Alzheimer disease Takeda M, Martinez R, Kudo T, Tanaka T,  Okochi M, Tagami S,  Morihara T,  Hashimoto R, Cacabelos R Asia-Pacific
Psychiatry 3; 10-6,
2011
3 Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M Biochem Biophys
Res Commun
415(3):519-25,
2011 
4 Gender difference in psychogeriatric disorders Takeda M, Tanaka T, Kudo T Geriatr Gerontol Int11:377-82,
 
2011
5 Involvement of puromycin-sensitve aminopeptidase in metabolism of tau protein in cultured cells Tanaka T, Yanagi K, Maruyama D, Takeda M   Int Psychogeriatr
23(Suppl.1):
S281-282, 2011
6 President's Message Takeda M IPA Bulletin 28(1), 2011
7 President's Message Takeda M IPA Bulletin 28(2), 2011
8 Can milnacipran used for neuropathic pain in patients with advanced cancer cause neuromuscular and somatosensory disorders? Nakagawa S, Okamoto Y, Tsuneto S, Tanimukai H, Goya S, Matsuda Y, Oono Y, Tsugane M, Uejima E J Palliat Med
14(4):403-5.
2011
9 ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse of platyspondylic lethal skeletal dysplasia, Torrance type Furuichi T,  Masuya H, Murakami T, Nishida K, Nishimura G, Suzuki T, Imaizumi K,  Kudo T, Ohkawa K, Wakana S, Ikegawa S Mamm Genome 22(5-6):318-28,
2011
10 Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population Kimura R, Morihara T, Kudo T, Kamino K, Takeda M Neurosci
 Let487:354-57,
2011
11 Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population Kimura R, Morihara T, Kudo T, Kamino K, Takeda M Neurosci
Lett487(3):354-7,
2011
12 Restraint-induced expression of endoplasmic reticulum stress-related genes in the mouse brain Ishisaka M, Kudo T, Shimazawa M,  Kakefuda K, Oyagi A, Hyakkoku K, Tsuruma K, Hara H Pharmacology &
Pharmacy 2(1):
10-6, 2011
13 Mental health care and east Japan great earthquake Takeda M Psychiatry Clin
Neurosci 65:
207-12, 2011
14 New drugs for Alzheimer's disease in Japan Takeda M, Tanaka T, Okochi M Psychiatry Clin
Neurosci  65(5):
399-404, 2011 
15 Elderly depression and diffusion tensor imaging Takeda M, Tanaka T, Kudo T Psychogeriatrics11
(1):1-5, 2011
16 Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M Psychogeriatrics
11(2):90-7,
 2011
17 The great eastern Japan earthquake and psychogeriatric services Takeda M, Tanaka T Psychogeriatrics11
(4):191-95,2011