腎疾患臓器連関制御学グループ
CKD患者の蛋白尿と腎不全の関連における季節変動(解説)
Nephrol Dial Transplant. Published online November 21, 2024. doi:10.1093/ndt/gfae278. PMID 39572085
Seasonal variations in the association between proteinuria, CKD, and kidney failure.
Takayuki Kawaoka, Yusuke Sakaguchi, Tatsufumi Oka, Yuta Asahina, Koki Hattori, Yohei Doi, Nobuhiro Hashimoto, Yasuo Kusunoki, Satoko Yamamoto, Masafumi Yamato, Ryohei Yamamoto, Isao Matsui, Masayuki Mizui, Jun-Ya Kaimori, Yoshitaka Isaka.
中止されたRAS阻害薬の再開が腎予後・生命予後を改善する(解説)
J Am Soc Nephrol. 2024 Jun 18. doi: 10.1681/ASN.0000000000000425. PMID 38889205
Estimated Effect of Restarting Renin-Angiotensin System Inhibitors after Discontinuation on Kidney Outcomes and Mortality.
Koki Hattori, Yusuke Sakaguchi, Tatsufumi Oka, Yuta Asahina, Takayuki Kawaoka, Yohei Doi, Nobuhiro Hashimoto, Yasuo Kusunoki, Satoko Yamamoto, Masafumi Yamato, Ryohei Yamamoto, Isao Matsui, Masayuki Mizui, Jun-Ya Kaimori, Yoshitaka Isaka.
尿中尿酸排泄率低値と慢性腎臓病進展の関連(解説)
Sci Rep. 2024 Mar 1;14(1):5119. doi: 10.1038/s41598-024-55809-9. PMID 38429496
Association between urinary uric acid excretion and kidney outcome in patients with CKD.
Asahina Y, Sakaguchi Y, Oka T, Hattori K, Kawaoka T, Doi Y, Yamamoto R, Matsui I, Mizui M, Kaimori JY, Isaka Y.
保存期CKDの診療におけるBNPモニタリングの意義(解説)
Am J Kidney Dis. 2023 Jun 23;S0272-6386(23)00692-3. doi: 10.1053/j.ajkd.2023.05.003. PMID 37354935
Association of Longitudinal B-Type Natriuretic Peptide Monitoring With Kidney Failure in Patients With CKD: A Cohort Study.
Tatsufumi Oka, Yusuke Sakaguchi, Koki Hattori, Yuta Asahina, Sachio Kajimoto, Wendy McCallum, Hocine Tighiouart, Mark J Sarnak, Jun-Ya Kaimori, Yoshitaka Isaka.
CKD患者における腎間質内好酸球集簇と腎予後の関連(解説)
Clin J Am Soc Nephrol. 2023 Aug 28. doi: 10.2215/CJN.0000000000000277. PMID 37639279
Interstitial Eosinophilic Aggregates and Kidney Outcome in Patients with CKD.
Koki Hattori, Yusuke Sakaguchi , Tatsufumi Oka, Yuta Asahina, Takayuki Kawaoka, Ryohei Yamamoto, Isao Matsui, Masayuki Mizui, Jun-Ya Kaimori, Yoshitaka Isaka
Canagliflozinの腎保護効果媒介因子は患者背景により異なる-CREDENCE trial-(解説)
Diabetes Obes Metab. 2023 Jun 29. doi: 10.1111/dom.15191. PMID 37385955
Mediators between canagliflozin and renoprotection vary depending on patient characteristics: Insights from the CREDENCE trial.
Yohei Doi, Takayuki Hamano, Satoshi Yamaguchi, Yusuke Sakaguchi, Jun‐Ya Kaimori, Yoshitaka Isaka
高齢血液透析患者における歩行機能とバランス能力に対するwhole body vibrationの効果(解説)
Clin J Am Soc Nephrol. 2023;18(1):84-90. PMID 36719160
A Randomized Controlled Trial of Whole-Body Vibration on Gait Ability and Balance among Older Hemodialysis Patients.
Yuta Asahina, Yusuke Sakaguchi, Sachio Kajimoto, Koki Hattori, Tatsufumi Oka, Jun-Ya Kaimori, Naoki Kashihara, Yoshitaka Isaka
LAMA5 ヘテロ遺伝子変異が、緩徐に進行しビンキュリン発現増加をみとめる巣状分節性糸球体硬化症と肺病変の発症に寄与する可能性がある(解説)
JCI Insight. 2022 Sep 29:e158378. PMID 36173685 DOI: 10.1172/jci.insight.158378
A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects.
Kaimori JY, Kikkawa Y, Motooka D, Namba-Hamano T, Takuwa A, Imai-Okazaki A, Kobayashi K, Tanigawa A, Kotani Y, Uno Y, Yoshimi K, Hattori K, Asahina Y, Kajimoto S, Doi Y, Oka T, Sakaguchi Y, Mashimo T, Sekiguchi K, Nakaya A, Nomizu M, Isaka Y.
VDRAの心血管アウトカムへの効果はALPによって修飾されるか？ - J-DAVID試験post-hoc解析(解説)
Sci Rep 2022;12(1):15463. PMID 36104443
Effects of alfacalcidol on cardiovascular outcomes according to alkaline phosphatase levels in the J-DAVID trial.
Oka T, Sakaguchi Y, Isaka Y, Ishii H, Kabata D, Shintani A, Nakatani S, Morioka T, Mori K, Inaba M, Emoto M, Shoji T.
進行した慢性腎臓病患者におけるアニオンギャップと心血管イベントの関連(解説)
Clin Kidney J. 2022; 15(5): 929-936. PMID 35498899
Time-updated anion gap and cardiovascular events in advanced chronic kidney disease: a cohort study.
Asahina Y, Sakaguchi Y, Kajimoto S, Hattori K, Doi Y, Oka T, Kaimori JY, Isaka Y.
アルドステロン拮抗薬の使用は多様な慢性腎臓病患者で透析・腎移植の回避と関連(解説)
Hypertension 2022; 79(3): 679-689. PMID 35026955
Mineralocorticoid Receptor Antagonist Use and Hard Renal Outcomes in Real-World Patients With Chronic Kidney Disease.
Oka T, Sakaguchi Y, Hattori K, Asahina Y, Kajimoto S, Doi Y, Kaimori JY, Isaka Y.
血液透析患者の透析中低血圧と身体活動性の関連(解説)
J Nephrol 2022 Jan 16. PMID 35034338
Intradialytic hypotension and objectively measured physical activity among patients on hemodialysis.
Hattori K, Sakaguchi Y, Kajimoto S, Asahina Y, Doi Y, Oka T, Kaimori JY, Isaka Y.
大阪府下の血液透析患者におけるSARS-CoV-2 IgG抗体陽性率に関する検討
(解説)
日腎会誌63巻7号
大阪府下の血液透析患者におけるSARS-CoV-2 IgG抗体陽性率に関する検討
坂口悠介、貝森淳哉、柏原直樹、猪阪善隆
進行した慢性腎臓病患者において高アニオンギャップは腎予後不良と関連する
(解説)
Am J Kidney Dis. 2021 Jul 15. PMID 34280508
Association of Time-Updated Anion Gap With Risk of Kidney Failure in Advanced CKD: A Cohort Study.
Asahina Y, Sakaguchi Y, Kajimoto S, Hattori K, Doi Y, Oka T, Kaimori JY, Isaka Y.
新しいMUC1のフレームシフト変異家を有する家族性尿細管間質腎炎患者家系の解析により明らかになった、変異MUC1蛋白の性質 (解説)
Nephrology Dialysis Transplantation. 2017. 32(12) 2010-2017 PMID 29156055
Analysis of an ADTKD family with a novel frameshift mutation in MUC1 reveals characteristic features of mutant MUC1 protein.
Yamamoto S, Kaimori JY, Yoshimura T, Namba T, Imai A, Kobayashi K, Imamura R, Ichimaru N, Kato K, Nakaya A, Takahara S, Isaka Y.
スピンエコーシークエンスと長時間DTI MRIによる糖尿病腎症における腎繊維化の可視化 (解説)
Sci Rep. 2017 Jul 18;7(1):5731. doi: 10.1038/s41598-017-06111-4. PMID 28720778
Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence.
Kaimori JY, Isaka Y, Hatanaka M, Yamamoto S, Ichimaru N, Fujikawa A, Shibata H, Fujimori A, Miyoshi S, Yokawa T, Kuroda K, Moriyama T, Rakugi H, Takahara S.
ARPKD異常によるNEDD4-family E3 ligaseの機能不全がARPKDの臨床像を説明できる可能性 (解説)
Scientific Reports, 7(7733) PMID 28798345
NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.
Kaimori JY, Lin CC, Outeda P, Garcia-Gonzalez MA, Menezes LF, Hartung EA , Li A, Wu G, Fujita H, Sato Y, Nakanuma Y, Yamamoto S, Ichimaru N, Takahara S, Isaka Y, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG.
ヒトの細胞において、ヒストンH4 lysine20 のアセチル化は遺伝子抑制と相関する (解説)
Scientific Reports. 2016 Apr 11;6:24318 PMID 27064113
Histone H4 lysine 20 acetylation is associated with gene repression in human cells.
Kaimori JY, Maehara K, Hayashi-Takanaka Y, Harada A, Fukuda M, Yamamoto S, Ichimaru N, Umehara T, Yokoyama S, Matsuda R, Ikura T, Nagao K, Obuse C, Nozaki N, Takahara S, Takao T, Ohkawa Y, Kimura H, Isaka Y.
アジルサルタンは近位尿細管のNa+-H+ Exchanger-3を調節してマウスの食塩感受性を改善する (解説)
PLoS One. 2016 Jan 25;11(1):e0147786. PMID 26807585
Azilsartan Improves Salt Sensitivity by Modulating the Proximal Tubular Na+-H+ Exchanger-3 in Mice.
Hatanaka M, Kaimori JY, Yamamoto S, Matsui I, Hamano T, Takabatake Y, Ecelbarger CM, Takahara S, Isaka Y, Rakugi H.