CKD-MBD
細胞レベルの空間分解能、秒レベルの時間分解で、in vivo のミトコンドリア脂肪酸β酸化を可視化する（解説）
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00147.2023. PMID 37729022
Spatiotemporally quantitative in vivo imaging of mitochondrial fatty acid β-oxidation at cellular-level resolution in mice.
Ayumi Matsumoto, Isao Matsui, Shohei Uchinomiya, Yusuke Katsuma, Seiichi Yasuda, Hiroki Okushima, Atsuhiro Imai, Takeshi Yamamoto, Akio Ojida, Kazunori Inoue, and Yoshitaka Isaka
肝臓によるリン捕捉および肝腎神経系を介したリン利尿亢進はリン恒常性維持に重要である（解説）
Sci Rep. 2023 Apr 8;13(1) :5794. doi: 10.1038/s41598-023-32856-2. PMID 37031318
Hepatic phosphate uptake and subsequent nerve-mediated phosphaturia are crucial for phosphate homeostasis following portal vein passage of phosphate in rats.
Seiichi Yasuda, Kazunori Inoue, Isao Matsui, Ayumi Matsumoto, Yusuke Katsuma, Hiroki Okushima, Atsuhiro Imai, Yusuke Sakaguchi, Jun-ya Kaimori, Ryohei Yamamoto, Masayuki Mizui, and Yoshitaka Isaka
腎移植後早期からの天然型ビタミンD3補充は骨密度低下を減弱させる（解説）
J Bone Miner Res. 2021 Nov 8. doi: 10.1002/jbmr.4469. PMID 34747516
Cholecalciferol supplementation attenuates bone loss in incident kidney transplant recipients: A prespecified secondary endpoint analysis of a randomized controlled trial.
Makoto Tsujita, Yohei Doi, Yoshitsugu Obi, Takayuki Hamano, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Norihiko Goto, Yoshitaka Isaka, Asami Takeda, Shunji Narumi, Yoshihiko Watarai.
バゾプレッシンを介した骨吸収亢進は運動誘発性高カルシウム血症と関連する（解説）
Osteoporos Int. 2021 June 17. PMID 34137899
Exercise-induced hypercalcemia and vasopressin-mediated bone resorption.
Senda M, Hamano T, Fujii N, Ito T, Sakaguchi Y, Matsui I, Isaka Y, Moriyama T.
心不全においてeGFRの変動は優れた予後予測因子である（解説）
ESC Heart Failure. PMID 34554643
Variability in estimated glomerular filtration rate and patients' outcomes in a real-world heart failure population.
Oka T, Hamano T, Ohtani T, Tanaka A, Doi Y, Yamaguchi S, Senda M, Sakaguchi Y, Matsui I, Nakamoto K, Sera F, Hikoso S, Nishino M, Sakata Y, Isaka Y.
低Na血症合併心不全における低用量トルバプタンの長期使用は良好な腎予後と関連する（解説）
ESC Heart Failure. PMID 34554640
Renoprotection by long-term low-dose tolvaptan in patients with heart failure and hyponatremia.
Oka T, Hamano T, Ohtani T, Doi Y, Shimada K, Matsumoto A, Yamaguchi S, Hashimoto N, Senda M, Sakaguchi Y, Matsui I, Nakamoto K, Sera F, Hikoso S, Sakata Y, Isaka Y.
マッソントリクローム染色標本を用いてポドサイト足突起や尿細管ミトコンドリア形態を定量評価する（解説）
Kidney Int Rep. 2021 May 1;6(7):1923-1938. PMID 34307987
Quantitative analyses of foot processes, mitochondria, and basement membranes using elastica Masson- and periodic-acid-Schiff-stained kidney sections by Structured Illumination Microscopy.
Matsumoto A, Matsui I, Katsuma Y, Yasuda S, Shimada K, Namba-Hamano T, Sakaguchi Y, Kaimori JY, Takabatake Y, Inoue K, Isaka Y.
腎移植後早期からの天然型ビタミンD3補充と移植腎機能；プラセボ対照無作為化比較試験（解説）
Am J Transplant. 2021 Feb 10. PMID 33565715
The effect of cholecalciferol supplementation on allograft function in incident kidney transplant recipients: A randomized controlled study.
Doi Y, Tsujita M, Hamano T, Obi Y, Namba-Hamano T, Tomosugi T, Futamura K, Okada M, Hiramitsu T, Goto N, Nishiyama A, Takeda A, Narumi S, Watarai Y, Isaka Y.
シングルセルRNA-seq解析を用いた腎発生メカニズムの検討（解説）
Sci Rep. 2021 Jan 8;11(1):73. PMID 33420268
Single cell RNA sequencing uncovers cellular developmental sequences and novel potential intercellular communications in embryonic kidney.
Matsui I, Matsumoto A, Inoue K, Katsuma Y, Yasuda S, Shimada K, Sakaguchi Y, Mizui M, Kaimori JY, Takabatake Y, Isaka Y.
活性型ビタミンD類似体による心筋肥大進展抑制機序（解説）
Cardiovasc Drugs Ther. 2020 Nov 18. PMID 33206298
Maxacalcitol (22-Oxacalcitriol (OCT)) Retards Progression of Left Ventricular Hypertrophy with Renal Dysfunction Through Inhibition of Calcineurin-NFAT Activity.
Inoue K, Matsui I, Hamano T, Okuda K, Tsukamoto Y, Matsumoto A, Shimada K, Yasuda S, Katsuma Y, Takabatake Y, Tanaka M, Tanaka N, Mano T, Minamino T, Sakata Y, Isaka Y.
カゼイン・卵白アルブミン・分枝鎖アミノ酸の経口摂取はリン誘導性腎尿細管間質障害を抑制する（解説）
Sci Rep. 2020 Nov 4;10(1):19038. PMID 33149246
Dietary casein, egg albumin, and branched-chain amino acids attenuate phosphate-induced renal tubulointerstitial injury in rats.
Shimada K, Matsui I, Inoue K, Matsumoto A, Yasuda S, Katsuma Y, Sakaguchi Y, Tanaka M, Sugimoto K, Kaimori JY, Takabatake Y, Isaka Y.
低重炭酸イオン血症とCKD進行リスクの関連はpH依存的である（解説）
Am J Kidney Dis. 2020 Aug 20. PMID 32828983
Modulation of the Association of Hypobicarbonatemia and Incident Kidney Failure With Replacement Therapy by Venous pH: A Cohort Study.
Kajimoto S, Sakaguchi Y, Asahina Y, Kaimori JY, Isaka Y.
腎移植患者における血清リン濃度は副甲状腺ホルモン濃度と腎予後との関連を修飾する（解説）
Sci Rep 10, 13766 (2020). PMID 32792668
Serum phosphate levels modify the impact of parathyroid hormone levels on renal outcomes in kidney transplant recipients.
Doi Y, Hamano T, Ichimaru N, Tomida K, Obi Y, Fujii N, Yamaguchi S, Oka T, Sakaguchi Y, Matsui I, Kaimori JY, Abe T, Imamura R, Takahara S, Tsubakihara Y, Nonomura N, Isaka Y.
リトコール酸はビタミンD受容体依存的、経細胞性経路非依存的に腸管のリン吸収を増加させる（解説）
Kidney Int. 2020 Feb 25. PMID 32354638
Lithocholic acid increases intestinal phosphate and calcium absorption in a vitamin D receptor dependent but transcellular pathway independent manner.
Hashimoto N, Matsui I, Ishizuka S, Inoue K, Matsumoto A, Shimada K, Hori S, Lee DG, Yasuda S, Katsuma Y, Kajimoto S, Doi Y, Yamaguchi S, Kubota K, Oka T, Sakaguchi Y, Takabatake Y, Hamano T, Isaka Y.
透析導入時の隠れ低カルシウム血症（解説）
Sci Rep. 2020 Mar 10; 10 (1):4418. PMID 32157180
Hidden Hypocalcemia as a Risk Factor for Cardiovascular Events and All-Cause Mortality among Patients Undergoing Incident Hemodialysis.
Yamaguchi S, Hamano T, Doi Y, Oka T, Kajimoto S, Kubota K, Yasuda S, Shimada K, Matsumoto A, Hashimoto N, Sakaguchi Y, Matsui I, Isaka Y.
内因性エリスロポエチン濃度とeGFR低下（解説）
Sci Rep. 2019 Oct 16;9(1):14871. PMID 31619722
Low erythropoietin levels predict faster renal function decline in diabetic patients with anemia: a prospective cohort study.
Fujita Y, Doi Y, Hamano T, Hatazaki M, Umayahara Y, Isaka Y, Tsubakihara Y.
保存期CKD患者の冠動脈石灰化に対する酸化マグネシウム/球形吸着炭の効果 – 2×2 ランダム化比較試験 –（解説）
J Am Soc Nephrol. 2019. Apr 29. PMID 31036759
A Randomized Trial of Magnesium Oxide and Oral Carbon Adsorbent for Coronary Artery Calcification in Predialysis CKD.
Sakaguchi Y, Hamano T, Obi Y, Monden C, Oka T, Yamaguchi S, Matsui I, Hashimoto N, Matsumoto A, Shimada K, Takabatake Y, Takahashi A, Kaimori JY, Moriyama T, Yamamoto R, Horio M, Yamamoto K, Sugimoto K, Rakugi H, Isaka Y.
低マグネシウム食はリン負荷による腎障害を悪化させる（解説）
Nephrol Dial Transplant. 2018 Dec 7. PMID 30535376
Low magnesium diet aggravates phosphate-induced kidney injury.
Sakaguchi Y, Hamano T, Matsui I, Oka T, Yamaguchi S, Kubota K, Shimada K, Matsumoto A, Hashimoto N, Isaka Y.
保存期CKD患者における血清Cl濃度と死亡・心血管イベントリスク（解説）
Nephrol Dial Transplant. 2018 Oct 20. PMID 30346587
Prognostic value of hypochloremia versus hyponatremia among patients with chronic kidney disease-a retrospective cohort study.
Kubota K, Sakaguchi Y, Hamano T, Oka T, Yamaguchi S, Shimada K, Matsumoto A, Hashimoto N, Mori D, Matsui I, Isaka Y.
CLCN5遺伝子のイントロン領域に新規変異を有し、重篤な骨軟化症を合併したデント病の一例（解説）
Intern Med. 2018 Aug 10. PMID 30101934
A Case of Severe Osteomalacia with Dent Disease Caused by a Novel Intronic Mutation of the CLCN5 gene.
Matsumoto A, Matsui I, Mori T, Sakaguchi Y, Mizui M, Ueda Y, Takahashi A, Doi Y, Shimada K, Yamaguchi S, Kubota K, Hashimoto N, Oka T, Takabatake Y, Sohara E, Hamano T, Uchida S, Isaka Y.
CKDできわめて高頻度に見られる電解質異常(低Mg血症)の新たな成因（解説）
Nephrology Dialysis Transplantation. 2018 May 22. PMID 29796601
Proteinuria-associated renal magnesium wasting leads to hypomagnesemia: a common electrolyte abnormality in chronic kidney disease.
Oka T, Hamano T, Sakaguchi Y, Yamaguchi S, Kubota K, Senda M, Yonemoto S, Shimada K, Matsumoto A, Hashimoto N, Mori D, Monden C, Takahashi A, Obi Y, Yamamoto R, Takabatake Y, Kaimori JY, Moriyama T, Horio M, Matsui I, Isaka Y.
心肥大は血清fibroblast growth factor 23 (FGF23)濃度を上昇させる（解説）
Kidney Int. 2018 May 8. PMID 29751971
Cardiac hypertrophy elevates serum levels of fibroblast growth factor 23.
Matsui I, Oka T, Kusunoki Y, Mori D, Hashimoto N, Matsumoto A, Shimada K, Yamaguchi S, Kubota K, Yonemoto S, Higo T, Sakaguchi Y, Takabatake Y, Hamano T, Isaka Y.
蛋白カルバミル化は血管石灰化を悪化させる（解説）
Kidney Int. 2018 Apr 28. PMID 29716796
Protein carbamylation exacerbates vascular calcification.
Mori D, Matsui I, Shimomura A, Hashimoto N, Matsumoto A, Shimada K, Yamaguchi S, Oka T, Kubota K, Yonemoto S, Sakaguchi Y, Takahashi A, Shintani Y, Takashima S, Takabatake Y, Hamano T, Isaka Y.
血液透析患者の血中イオン化マグネシウム濃度とアニオンギャップ（解説）
Clin J Am Soc Nephrol. 13(2); 274-281. PMID 29180531
Anion Gap as a Determinant of Ionized Fraction of Divalent Cations in Hemodialysis Patients.
Sakaguchi Y, Hamano T, Kubota K, Oka T, Yamaguchi S, Matsumoto A, Hashimoto N, Mori D, Obi Y, Matsui I, Isaka Y.
保存期CKD患者における血清Mg濃度と冠動脈石灰化密度の関係（解説）
PLoS One. 11(9):e0163673, 2016. doi: 10.1371/journal.pone.0163673. PMID 27662624
Association between Density of Coronary Artery Calcification and Serum Magnesium Levels among Patients with Chronic Kidney Disease.
Sakaguchi Y, Hamano T, Nakano C, Obi Y, Matsui I, Kusunoki Y, Mori D, Oka T, Hashimoto N, Takabatake Y, Takahashi A, Kaimori JY, Moriyama T, Yamamoto R, Horio M, Sugimoto K, Yamamoto K, Rakugi H, Isaka Y.
腎尿細管間質障害に対する25-hydroxyvitamin D3の直接作用（解説）
Kidney Int. 2015; 88(5): 1013-29. PMID 26176830
Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury by modulating the phenotype of macrophages in mice
Kusunoki Y, Matsui I, Hamano T, Shimomura A, Mori D, Yonemoto S, Takabatake Y, Tsubakihara Y, St-Arnaud R, Isaka Y, and Rakugi H.
マグネシウムは非糖尿病性慢性腎臓病患におけるリンと腎不全進行リスクの関連を修飾する（解説）
Kidney Int. 2015; 88(4): 833-42. PMID 26061542
Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease
Sakaguchi Y, Iwatani H, Hamano T, Tomida K, Kawabata H, Kusunoki Y, Shimomura A, Matsui I, Hayashi T, Tsubakihara Y, Isaka Y, and Rakugi H.
L-リジンは血管石灰化を抑制する（解説）
J Am Soc Nephrol 2014; 25: 1954-65, PMID 24652795
Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats
Shimomura A, Matsui I, Hamano T, Ishimoto T, Katou Y, Takehana K, Inoue K, Kusunoki Y, Mori D, Nakano C, Obi Y, Fujii N, Takabatake Y, Nakano T, Tsubakihara Y, Isaka Y, Rakugi H.
ビタミンDの欠乏は 移植腎機能の低下を予測する（解説）
J Clin Endocrinol Metab 2014; 99: 527-35, PMID 24285688
Vitamin D deficiency predicts decline in kidney allograft function: a prospective cohort study.
Obi Y, Hamano T, Ichimaru N, Tomida K, Matsui I, Fujii N, Okumi M, Kaimori JY, Yazawa K, Kokado Y, Nonomura N, Rakugi H, Takahara S, Isaka Y, Tsubakihara Y.
ステロイド骨粗鬆症におけるMDCTの有用性（解説）
J Bone Miner Metab 2014; 32: 271-80, PMID 23832575
Multidetector-row computed tomography is useful to evaluate the therapeutic effects of bisphosphonates in glucocorticoid-induced osteoporosis.
Inoue K, Hamano T, Nango N, Matsui I, Tomida K, Mikami S, Fujii N, Nakano C, Obi Y, Shimomura A, Kusunoki Y, Rakugi H, Isaka Y, Tsubakihara Y.
異所性石灰化抑制因子fetuin-Aの腎臓における役割（解説）
Am J Physiol Renal Physiol 2013; 304: F751-60, PMID 23344571
Retention of fetuin-A in renal tubular lumen protects the kidney from nephrocalcinosis in rats.
Matsui I, Hamano T, Mikami S, Inoue K, Shimomura A, Nagasawa Y, Michigami T, Ohnishi T, Fujii N, Nakano C, Kusunoki Y, Kitamura H, Iwatani H, Takabatake Y, Kaimori JY, Matsuba G, Okoshi K, Kimura-Suda H, Tsubakihara Y, Rakugi H, Isaka Y.
活性型ビタミンD類似体による腎尿細管間質線維化抑制作用 （解説）
Lab Invest 2012; 92: 1686-97, PMID 22926646
Maxacalcitol ameliorates tubulointerstitial fibrosis in obstructed kidneys by recruiting PPM1A/VDR complex to pSmad3.
Inoue K, Matsui I, Hamano T, Fujii N, Shimomura A, Nakano C, Kusunoki Y, Takabatake Y, Hirata M, Nishiyama A, Tsubakihara Y, Isaka Y, Rakugi H.
保存期慢性腎臓病(CKD)患者におけるFGF23と25(OH)D測定の併用は、腎予後のリスク評価に有用（解説）
Clin J Am Soc Nephrol 2012; 7: 810-9, PMID 22362065
Combined use of vitamin D status and FGF23 for risk stratification of renal outcome.
Nakano C, Hamano T, Fujii N, Matsui I, Tomida K, Mikami S, Inoue K, Obi Y, Okada N, Tsubakihara Y, Isaka Y, Rakugi H.
保存期慢性腎臓病(CKD)患者のFGF23値は、透析導入前の心血管病発症を予測するが、透析導入後の心血管病発症までは予測しない（解説）
Bone 2012; 50: 1266-74, PMID 22425694
Intact fibroblast growth factor 23 levels predict incident cardiovascular event before but not after the start of dialysis.
Nakano C, Hamano T, Fujii N, Obi Y, Matsui I, Tomida K, Mikami S, Inoue K, Shimomura A, Nagasawa Y, Okada N, Tsubakihara Y, Rakugi H, Isaka Y.
慢性腎臓病患者さんにおける冠動脈石灰化とfetuin-mineral complex（解説）
J Am Soc Nephrol 2010; 21: 1998-2007, PMID 20947626
Fetuin-mineral complex reflects extraosseous calcification stress in CKD.
Hamano T, Matsui I, Mikami S, Tomida K, Fujii N, Imai E, Rakugi H, Isaka Y.
慢性腎臓病患者におけるビタミンD代謝異常と糖尿病（解説）
Bone 2009; 45: 949-55, PMID 19631779
The impact of diabetes mellitus on vitamin D metabolism in predialysis patients.
Tanaka H, Hamano T, Fujii N, Tomida K, Matsui I, Mikami S, Nagasawa Y, Ito T, Moriyama T, Horio M, Imai E, Isaka Y, Rakugi H.
非糖尿病慢性腎臓病患者における25-hydroxyvitamin D（解説）
Bone 2009; 44: 678-83, PMID 19111635
Serum 25-hydroxyvitamin D as an independent determinant of 1-84 PTH and bone mineral density in non-diabetic predialysis CKD patients.
Tomida K, Hamano T, Mikami S, Fujii N, Okada N, Matsui I, Nagasawa Y, Moriyama T, Ito T, Imai E, Isaka Y, Rakugi H.
糸球体上皮細胞傷害の修復とvitamin D（解説）
Nephrol Dial Transplant 2009; 24: 2354-61, PMID 19297354
Active vitamin D and its analogue, 22-oxacalcitriol, ameliorate puromycin aminonucleoside-induced nephrosis in rats.
Matsui I, Hamano T, Tomida K, Inoue K, Takabatake Y, Nagasawa Y, Kawada N, Ito T, Kawachi H, Rakugi H, Imai E, Isaka Y.
腎不全における異所性石灰化のメカニズム（解説）
Kidney Int 2009; 75: 915-28, PMID 19190677
Fully phosphorylated fetuin-A forms a mineral complex in the serum of rats with adenine-induced renal failure.
Matsui I, Hamano T, Mikami S, Fujii N, Takabatake Y, Nagasawa Y, Kawada N, Ito T, Rakugi H, Imai E, Isaka Y.